<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30208
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | REEKQLELSLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLMRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDATRISADAAQKQIQSLNKICSNLLEKISKEERESESGGITLEWRPFNPADTNALVAAVAFGKGLSNRRPPGSGGPVQASQPGASAILAGASGIQQVQMSGASSQQQPMLGGVQMPQAGQPGKIPSGIKTNIKSASMHPYQR |
Length | 266 |
Position | Head |
Organism | Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae>
Pelodiscus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.463 |
Instability index | 45.21 |
Isoelectric point | 6.17 |
Molecular weight | 29092.70 |
Publications | PubMed=17381049
PubMed=23624526
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30208
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 128.27| 33| 35| 187| 219| 1
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155- 187 (35.74/15.30) ...EERESESGG...ITlewRPFNPADTNALVAAVAFGK
188- 220 (58.97/29.21) GLSNRRPPGSGG...PV...QASQPGASAILAGASGIQQ
225- 251 (33.56/13.99) GASSQQQPMLGGvqmP....QAGQPG..KIPSG......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.40| 12| 16| 60| 71| 2
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60- 71 (21.05/13.31) VLKHEK.TPLMRN
78- 90 (16.35/ 8.96) VLSPDRdEEIMRQ
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