Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | ICPVETEKLNKMSSLLERLHAKFNQNRPWTETMKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAVMYWQATNASPLDKILHGSVGYLTPRSGGHLMNLKYYISPYDLFEEGTGNPIVLHENNVPRSLGMNASITIEGTLAMSKLPIAPLIMGSHPVDNKGTPSFSSVTSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTPPTFVPLYELITQFELSKETDSVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDMQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKDNPPQDFSTLYGSSPLERQNSSSGSPRMEIGPGGNKQKKKKSRTPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQSIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEAAKLPSTNEDCPAIGTPVRDSSSSGHSQSALFDPDVFQTTSENPYTDPADLIADATVSPSSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSRDADDFKGFPSQALTSLGVQVLGGDGGENKFKGSSQTDMVDFSIIAAASKTLGPSDIMEHHSGSQSPLLSTGDLGKEKSQKRVKEGGNGSGSSLSSAVLDGKPGKRSRTPSSDGKSKEKLPKRKKADIEGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSSASGKVKSSKSEGSSGSKMSSSLYVSQGGSGSGQSKSSAQSVGKPGSSPITKHGLSSSSGGTKVKPQGKPSSLMNTSMPKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGTHMSGTGSGSNMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSTGSSMSSSQNQHGSSKGKSPSRNKKPSLIAVIDKLKHGVVTSGPGGEDSMDGQMGPSSNSSSHSLSSKHNMSGGEFQGKREKSDKDKSKVSVGSVDSSKKTSDSKNIGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSSAILSADRPSRPSPDFLIGEEDDDLMDVALMGN |
Length | 1574 |
Position | Middle |
Organism | Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.623 |
Instability index | 56.16 |
Isoelectric point | 8.90 |
Molecular weight | 167365.37 |
Publications | PubMed=17381049 PubMed=23624526 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP30194 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 6| 276.28| 42| 42| 1194| 1235| 1 --------------------------------------------------------------------------- 915- 963 (34.68/ 6.09) ..GSSQTD.MvdfsiiaaaSKTLGPSdI....................MEH..HSGS.QSPLLST.....GDLGK.EKSQK 1070- 1111 (51.15/12.84) PSHSQYTS.S.........GSVSSSS.S....................KSH..HSHSSSSSSSSS.....SASGK.VKSSK 1112- 1156 (45.10/10.36) SEGSSGSK.M.........SSSLYVS.Q.................ggsGSG..QSKSSAQSV.GK.....PGSSPiTKHGL 1157- 1218 (56.58/15.07) SSSSGGTK.V.........KPQGKPS.SlmntsmpkpnispshsrpsgGSD..KLASPMKPVPGT.....PPSSK.AKSPI 1219- 1261 (50.39/12.53) SSGSGGTH.M.........SGTGSGS.N..........mksssgmgssGS......MSQKP.........PPSSN.S.STA 1309- 1358 (38.38/ 7.61) TSGPGGEDsM.........DGQMGPS.S....................NSSshSLSSKHNMSGGEfqgkrEKSDK.DKSKV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 6| 559.20| 96| 96| 649| 744| 2 --------------------------------------------------------------------------- 413- 538 (58.38/18.84) .YNTLIGSC..VKRtvlKEDSPGILQFEVCPLS......D.......SC........................FS..VSFQHPVNDslVCVVMDMQDS.......THvncklykglsdalictddfIAKVV..QRCMSIPvtmrairrkaetiqadtpalsliaetvedmvkknLPP 539- 651 (100.80/38.09) ASSPGYGMTT.GSN...PMSGTTTPTNTF.PGGpittlfN.......MSMSMKER..HDSVGHG..EDFSK......V.SQNPILTslLQITGNVGSTigssptpPH...................HTPPP....VSSPA..................sntknhpmlmnllkdnPPQ 652- 749 (168.12/68.63) DFSTLYGSSP.LER...QNSSSGSPRMEIGPGG......N.......KQKKKKSRTPADKPKHQTEDDFQRELFSMDVDSQNPIFD..VNMTADTLDT.......PH...................ITPAP..SQCSTPP................................ttYPQ 750- 843 (85.97/31.36) ...SIPHSQPsIQR.mvRLSSSDS....IGADV......TdilsdiaEEAAKLPSTNEDCPAIGTP...VRD.SSSSGHSQSALFD..PDVFQTTSEN.......PY...................TDPADliADATVSP..................................... 844- 911 (68.19/23.29) .................SSDSSN....HFFPDG...................VDFNP.DLLNSQSQSGFGEEYF..DESSQ.............SRDA.......DD...................FKGFP..SQALTSL.........................gvqvlggdgGEN 974- 1046 (77.74/27.62) ..SSL.................SSAVLDGKPG...................KRSRTPSSDGKSK.EKLPKRK..KADIEGKSP........SHSSSNR.......PF...................TPPAS..TGGSKSP..........................gssgrsqtPP. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 133.63| 32| 96| 1265| 1298| 3 --------------------------------------------------------------------------- 1265- 1296 (57.94/21.63) SFSSTGSSM.SSSQN.QHGSSKGKSPSRNKKPS...L 1418- 1447 (40.91/11.72) SSKSYGSPLiSGSTP.KHERC...SPSHSKSPA...Y 1525- 1558 (34.78/ 8.16) SWSK..SPI.SSDQSlSMTSSAILSADRPSRPSpdfL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 114.58| 38| 47| 307| 353| 4 --------------------------------------------------------------------------- 307- 353 (52.61/45.12) IPvsrafiqKLQSCTGIPLfDTP.PTFVPLY.ELITQFELsKETDSVPL 363- 402 (61.97/31.22) LP.......GQQHCYFLNK.DAPlPDGRSLQgTLISKIAF.QHPGRVPL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.80| 15| 97| 1361| 1376| 6 --------------------------------------------------------------------------- 1361- 1375 (23.74/13.01) GSVDSSKKTSDSKNI 1381- 1395 (25.06/ 8.55) AKIIISKHDGGSPSI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 96.25| 29| 48| 142| 171| 7 --------------------------------------------------------------------------- 142- 171 (47.69/32.05) NFDEFSKHLKGLVNlYKLP..GDNKLKTKMYL 192- 222 (48.57/28.34) NASPLDKILHGSVG.YLTPrsGGHLMNLKYYI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IPKITIQIPK 2) IRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDR 3) KLPKRKK 4) RNKKPSLIAVIDKLKHGV 5) SADRPSRPSPDFLIGEEDDDLMDVALMGN 6) SIKAKVTLQK 7) VAKIIISKH 8) YGSPLI | 1053 1477 1001 1290 1546 1394 1380 1422 | 1062 1509 1007 1307 1574 1403 1388 1427 |
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