<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30194

Description Mediator of RNA polymerase II transcription subunit 1
SequenceICPVETEKLNKMSSLLERLHAKFNQNRPWTETMKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAVMYWQATNASPLDKILHGSVGYLTPRSGGHLMNLKYYISPYDLFEEGTGNPIVLHENNVPRSLGMNASITIEGTLAMSKLPIAPLIMGSHPVDNKGTPSFSSVTSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTPPTFVPLYELITQFELSKETDSVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDMQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKDNPPQDFSTLYGSSPLERQNSSSGSPRMEIGPGGNKQKKKKSRTPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQSIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEAAKLPSTNEDCPAIGTPVRDSSSSGHSQSALFDPDVFQTTSENPYTDPADLIADATVSPSSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSRDADDFKGFPSQALTSLGVQVLGGDGGENKFKGSSQTDMVDFSIIAAASKTLGPSDIMEHHSGSQSPLLSTGDLGKEKSQKRVKEGGNGSGSSLSSAVLDGKPGKRSRTPSSDGKSKEKLPKRKKADIEGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSSASGKVKSSKSEGSSGSKMSSSLYVSQGGSGSGQSKSSAQSVGKPGSSPITKHGLSSSSGGTKVKPQGKPSSLMNTSMPKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGTHMSGTGSGSNMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSTGSSMSSSQNQHGSSKGKSPSRNKKPSLIAVIDKLKHGVVTSGPGGEDSMDGQMGPSSNSSSHSLSSKHNMSGGEFQGKREKSDKDKSKVSVGSVDSSKKTSDSKNIGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSSAILSADRPSRPSPDFLIGEEDDDLMDVALMGN
Length1574
PositionMiddle
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.04
Grand average of hydropathy-0.623
Instability index56.16
Isoelectric point8.90
Molecular weight167365.37
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     276.28|      42|      42|    1194|    1235|       1
---------------------------------------------------------------------------
  915-  963 (34.68/ 6.09)	..GSSQTD.MvdfsiiaaaSKTLGPSdI....................MEH..HSGS.QSPLLST.....GDLGK.EKSQK
 1070- 1111 (51.15/12.84)	PSHSQYTS.S.........GSVSSSS.S....................KSH..HSHSSSSSSSSS.....SASGK.VKSSK
 1112- 1156 (45.10/10.36)	SEGSSGSK.M.........SSSLYVS.Q.................ggsGSG..QSKSSAQSV.GK.....PGSSPiTKHGL
 1157- 1218 (56.58/15.07)	SSSSGGTK.V.........KPQGKPS.SlmntsmpkpnispshsrpsgGSD..KLASPMKPVPGT.....PPSSK.AKSPI
 1219- 1261 (50.39/12.53)	SSGSGGTH.M.........SGTGSGS.N..........mksssgmgssGS......MSQKP.........PPSSN.S.STA
 1309- 1358 (38.38/ 7.61)	TSGPGGEDsM.........DGQMGPS.S....................NSSshSLSSKHNMSGGEfqgkrEKSDK.DKSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     559.20|      96|      96|     649|     744|       2
---------------------------------------------------------------------------
  413-  538 (58.38/18.84)	.YNTLIGSC..VKRtvlKEDSPGILQFEVCPLS......D.......SC........................FS..VSFQHPVNDslVCVVMDMQDS.......THvncklykglsdalictddfIAKVV..QRCMSIPvtmrairrkaetiqadtpalsliaetvedmvkknLPP
  539-  651 (100.80/38.09)	ASSPGYGMTT.GSN...PMSGTTTPTNTF.PGGpittlfN.......MSMSMKER..HDSVGHG..EDFSK......V.SQNPILTslLQITGNVGSTigssptpPH...................HTPPP....VSSPA..................sntknhpmlmnllkdnPPQ
  652-  749 (168.12/68.63)	DFSTLYGSSP.LER...QNSSSGSPRMEIGPGG......N.......KQKKKKSRTPADKPKHQTEDDFQRELFSMDVDSQNPIFD..VNMTADTLDT.......PH...................ITPAP..SQCSTPP................................ttYPQ
  750-  843 (85.97/31.36)	...SIPHSQPsIQR.mvRLSSSDS....IGADV......TdilsdiaEEAAKLPSTNEDCPAIGTP...VRD.SSSSGHSQSALFD..PDVFQTTSEN.......PY...................TDPADliADATVSP.....................................
  844-  911 (68.19/23.29)	.................SSDSSN....HFFPDG...................VDFNP.DLLNSQSQSGFGEEYF..DESSQ.............SRDA.......DD...................FKGFP..SQALTSL.........................gvqvlggdgGEN
  974- 1046 (77.74/27.62)	..SSL.................SSAVLDGKPG...................KRSRTPSSDGKSK.EKLPKRK..KADIEGKSP........SHSSSNR.......PF...................TPPAS..TGGSKSP..........................gssgrsqtPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.63|      32|      96|    1265|    1298|       3
---------------------------------------------------------------------------
 1265- 1296 (57.94/21.63)	SFSSTGSSM.SSSQN.QHGSSKGKSPSRNKKPS...L
 1418- 1447 (40.91/11.72)	SSKSYGSPLiSGSTP.KHERC...SPSHSKSPA...Y
 1525- 1558 (34.78/ 8.16)	SWSK..SPI.SSDQSlSMTSSAILSADRPSRPSpdfL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.58|      38|      47|     307|     353|       4
---------------------------------------------------------------------------
  307-  353 (52.61/45.12)	IPvsrafiqKLQSCTGIPLfDTP.PTFVPLY.ELITQFELsKETDSVPL
  363-  402 (61.97/31.22)	LP.......GQQHCYFLNK.DAPlPDGRSLQgTLISKIAF.QHPGRVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      15|      97|    1361|    1376|       6
---------------------------------------------------------------------------
 1361- 1375 (23.74/13.01)	GSVDSSKKTSDSKNI
 1381- 1395 (25.06/ 8.55)	AKIIISKHDGGSPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.25|      29|      48|     142|     171|       7
---------------------------------------------------------------------------
  142-  171 (47.69/32.05)	NFDEFSKHLKGLVNlYKLP..GDNKLKTKMYL
  192-  222 (48.57/28.34)	NASPLDKILHGSVG.YLTPrsGGHLMNLKYYI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30194 with Med1 domain of Kingdom Metazoa
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