<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30192

Description Mediator complex subunit 14
SequenceAPAPPAPXXXXXXASPGYRLSALIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVVGRKTGTASLHKVTIKIDENDVSKPLQISHEPPLPASDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVVPILEPCGRSECLHVFVDLHSGMFQLMLYGLDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVTSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFEVPGNPTELEYKNYFLSVSYPEGDDCPATALLLQQFKPNIEELVLDIKSGKQAKGGAKRKLSGDPCSVESKKPKRSGEMCAFNKVLAHLVAMCDTNMPFIGLRMELSNMEIPHQGVQVEGDGFSHAIRLLKGRIPPCKGTSEETQKALDRSLLDCTFRLQGRNNRTWVAELIFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPEIPNHLNVFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLVAINKLPTVPMLGLTHRINIAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQSQQQHFQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTGSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALNPKTNQTLQLKVTPENAGQWKPEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKATVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMLVSSILKRFAELNSPRPGECTIFGAVRDLMVNLALPPGGRP
Length1428
PositionTail
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.07
Grand average of hydropathy-0.186
Instability index52.76
Isoelectric point8.89
Molecular weight157818.61
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30192
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     209.62|      30|      32|    1008|    1037|       1
---------------------------------------------------------------------------
  955- 1000 (34.11/12.13)	PPSPiggDMMDSlisqlqpqqsqqqhFQPFAKQAGASGAYPLTSP.P
 1008- 1037 (55.51/24.10)	TPSP...SMMHT..............QSPGNLHAASSPSGALRAPSP
 1043- 1071 (45.54/18.52)	TPSP...SSLGI...............TMGQTANFASPHGTIDPSSP
 1075- 1095 (37.35/13.95)	M.SP...S..................QRAGNWPGSPQVSG....PSP
 1103- 1130 (37.10/13.81)	SPAN...PSLHS..............PVPDASHSPRAGTGSQTMP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.04|      27|      30|     224|     250|       4
---------------------------------------------------------------------------
  224-  250 (45.01/35.85)	EDKETGDGRALVHSMQISFIHQLVQSR
  254-  280 (48.03/38.86)	DEKPLQDMYNCLHSFCLSLQLEVLHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.47|      28|     159|    1141|    1186|       5
---------------------------------------------------------------------------
 1141- 1170 (42.65/43.87)	QRSWAASIPTILTHSALNilLLPSPTPGLV
 1188- 1215 (45.82/14.75)	SVIMRRHLQRIIQQETLQ..LINSNEPGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      30|     104|     114|       8
---------------------------------------------------------------------------
  104-  114 (16.90/ 8.84)	RLASLARDALV
  137-  147 (20.20/12.01)	RLPTCIRDKII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.38|      13|      30|     328|     341|      11
---------------------------------------------------------------------------
  328-  341 (17.29/18.84)	IKIDENDVSKpLQI
  359-  371 (22.09/16.31)	MKIDHLSIEK.LLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.46|      32|      47|     806|     839|      13
---------------------------------------------------------------------------
  806-  839 (50.57/38.75)	LGTVgPNSGCSNCHNtILHQLQEMFNKTPNVVQL
  856-  887 (58.90/35.53)	LPTV.PMLGLTHRIN.IAYQCFSILPQSPTHIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.84|      39|     228|     461|     500|      15
---------------------------------------------------------------------------
  461-  500 (67.43/44.91)	WLQQLKFWLGQQRCKQSIKHLPTvTSETLQLANYASHPVG
  691-  729 (70.41/42.82)	WVAELIFANCPLNSTSSREQGPT.RHVYLTYENQLSEPVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.03|      37|     493|     762|     799|      19
---------------------------------------------------------------------------
  762-  799 (63.81/46.84)	PNHLNV...FSEVRV....YNYRKLIlCYGTTKGSSISIQWNSIH
 1250- 1293 (54.22/34.75)	PEELQVlekFFETRVagppFKANTLI.AFTKLLGAPTHILRDCVH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30192 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQSQQQHFQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTGSQTMPTNMPPPRKLPQRSWA
942
1145










Molecular Recognition Features






MoRF SequenceStartStop




NANANA