<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30191

Description Mediator complex subunit 14
SequenceMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVVGRKTGTASLHKVTIKIDENDVSKPLQISHEPPLPASDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVVPILEPCGRSECLHVFVDLHSGMFQLMLYGLDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVTSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFEVPGNPTELEYKNYFLSVSYPEGDDCPATALLLQQFKPNIEELVLDIKSGKQAKGGAKRKLSGDPCSVESKKPKRSGEMCAFNKVLAHLVAMCDTNMPFIGLRMELSNMEIPHQGVQVEGDGFSHAIRLLKIPPCKGTSEETQKALDRSLLDCTFRLQGRNNRTWVAELIFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPEIPNHLNVFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLVAINKLPTVPMLGLTHRINIAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQSQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALNPKTNQTLQLKVTPENAGQWKPEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKATVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMLVSSILKRFAELNSPRPGECTIFGAVRDLMVNLALPPGGRP
Length1375
PositionTail
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.07
Grand average of hydropathy-0.188
Instability index53.31
Isoelectric point8.87
Molecular weight152707.79
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30191
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     202.00|      30|      32|     956|     985|       1
---------------------------------------------------------------------------
  907-  948 (30.55/12.38)	.PSPiggDMMD.SlisqlqpqqsqQQPFAKQAGASGAYPLTSP.P
  956-  985 (59.54/32.36)	TPSP...SMMH.T...........QSPGNLHAASSPSGALRAPSP
  991- 1019 (46.89/23.65)	TPSP...SSLG.I............TMGQTANFASPHGTIDPSSP
 1021- 1043 (27.77/10.47)	.......TMMSpS...........QRAGNWPGSPQVSG....PSP
 1051- 1073 (37.25/17.00)	SPAN...PSLH.S...........PVPDASH...SP....RAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.95|      23|      28|     168|     190|       2
---------------------------------------------------------------------------
  168-  190 (36.04/30.63)	RLLKLEILVEDKETGDGRALVHS
  198-  220 (38.91/33.83)	QLVQSRLFADEKPLQDMYNCLHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     231.06|      64|     123|     600|     721|       3
---------------------------------------------------------------------------
  100-  141 (56.54/12.48)	IPPDPITKTEKQTTLHQLNQILRHRLVTTDLPPQLANLTVA...N.......................
  609-  673 (108.88/152.82)	IPPCKGTSEETQKALDRSLLDCTFRLQGRNNRTWVAELIFA...NCPLNSTSSREQGPTrHVYLTYEN
  792-  842 (65.63/19.36)	................QVLFDTQAPLVAINKLPTVPMLGLThriNIAYQCFSILPQSPT.HIRLAFRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.17|      41|     114|     419|     482|       4
---------------------------------------------------------------------------
  262-  324 (52.45/20.53)	W.NQQVVgrKTGTASLHKVTikidendvSKPLQISHEPPLPasdsklmeramkIDHLSIEKLLI
  421-  462 (70.72/71.59)	WlGQQRC..KQSIKHLPTVT........SETLQLANYASHP............VGNLSKHKLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     313.87|      99|     210|     473|     579|       5
---------------------------------------------------------------------------
  473-  579 (152.59/116.76)	VVEMFEVPGNPTELEYkNYFLSV..SYPEgddCPATALLLQQFK.PNIEELVLDIKSGKQAK.....GGAKRKLSgdpCSVESKKPKRSGEMCaFNKVLAHLVAMCDTNMPFIGL
  684-  790 (161.28/99.07)	VVEMFLNDWNSIARLY.ECVLEFarSLPE...IPNHLNVFSEVRvYNYRKLILCYGTTKGSSisiqwNSIHQKFH...ISLGTVGPNSGCSNC.HNTILHQLQEMFNKTPNVVQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30191 with Med14 domain of Kingdom Metazoa
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