<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30190

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTLLAPVNGLHGFCLLFCSDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDILNKKSQASVSDPMNALQNLTGGPPAGAAGMGMASRAPGAPMGGLSGLGPMGQQMSLPGQQPPGTSGMAPHGMTGVSAATQQTQLQLQQMAKLQMQQQQQNQQQPVTFTQQQLKAMQVSALKTQSQWLCALRATREIAQHSALLTAFQVRAQLVQQQQAAAAAQAAQAQAAQMGASGQYCIMLSPVQNPPGPPAPQVAQPGWARHRPPQLPSPPQPRNSRCQAKFGKPLQSVVPLSSKMITATMARGGMQIRPRFPPTTAVSATPPSSIPLGGQQMPQSSITMMSSPSPVQQVQTPQSMPPPPQPQLAIEHPHTDTHSRAYSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAQMASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIDNSRQYAANPFLQSVYQYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length703
PositionTail
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.04
Grand average of hydropathy-0.463
Instability index71.68
Isoelectric point9.74
Molecular weight76238.88
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     572.55|     123|     124|     177|     299|       1
---------------------------------------------------------------------------
   43-  157 (105.19/23.49)	...............................MKAkTREeyLSLVARLIIHF..RDILNKKSQASVSDpmNALQnltggppAGAAGMGmasrAPGAP......M.GGLSG.....L.............GPMGQQMS..LP..........G.................................QQPPG.TSG.MAPHGmtgvS....AATQQTQLQLQQMAKL
  177-  299 (217.21/54.73)	LKAMQVSA.............LKTQSQWLCALRA.TRE..IAQHSALLTAFQVRAQLVQQQQAAAAA..QAAQ.......AQAAQMG....ASGQY......C.IMLSP.....VQN......P...PGPPAPQVA..QP..........GW..............................ARHRPPQLPSP.PQPRN....S....RCQAKFGKPLQSVVPL
  304-  424 (118.61/27.23)	ITATMARG.........................................GMQIRPRF....PPTTAV..SATP.......PSSIPLG......GQQmpqssiT.MMSSPspvqqVQT......PqsmPPPPQPQLAieHPhtdthsraysGP..............................APSPSSFLPSPsPQPSQ....SpaaaRTPQNFSVP..SPGPL
  430-  590 (131.54/30.84)	PNSVMSPAsssqseeqqylekLKQLSKYIEPLR...RM..INK....IDKNEDRKKDLSKMKSLLDI..LTDP.......SKRCPL.....KTLQK......CeIALEK.....LKNdmavptP...PPPPVPPTK..QQ..........YLcqplldavlanirspvfnhslyrtfvpamtAIHGPPITAQM.ASPR............KRKYEEDERQTIP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.45|      25|      25|     643|     667|       2
---------------------------------------------------------------------------
  643-  667 (45.91/28.33)	DYPDQSPLWIDNSRQYAA..NPFLQSV
  669-  695 (38.54/22.55)	QYMTSKLLQLPDKHSVTAllNTWAQSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30190 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IMLSPVQNPPGPPAPQVAQPGWARHRPPQLPSPPQPRNSRCQAKFGKP
2) QASVSDPMNALQNLTGGPPAGAAGMGMASRAPGAPMGGLSGLGPMGQQMSLPGQQPPGTSGMAPHGMTGVSAATQ
3) VVPLSSKMITATMARGGMQIRPRFPPTTAVSATPPSSIPLGGQQMPQSSITMMSSPSPVQQVQTPQSMPPPPQPQLAIEHPHTDTHSRAYSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
245
71
296
292
145
453










Molecular Recognition Features






MoRF SequenceStartStop




NANANA