<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30189

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDILNKKSQASVSDPMNALQNLTGGPPAGAAGMGMASRAPGAPMGGLSGLGPMGQQMSLPGQQPPGTSGMAPHGMTGVSAATQQTQLQLQQMALKLQMQQQQQNQQQITASQLATPQQQLKAMQVSALKTQSQWLCALRATREIENLPAQHSALLTVVEQVYEIVQCIKVRAQLVQQQQAAAAAQAAQAQAAQMGASGQYTPASMPVLPCVPSTKHGIHGFSHMLLDPPPTGPPSSPGGPAGLHAELSDPLFAWLGQAPASPTSFPPPTQAFRAPLTHTLQQSNIQPFHEQSNLANRVVQYAQLVALGKEVNQSSITMMSSPSPVQQVQTPQSMPPPPQPQLAIEHPHTDTHSRAYSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAQMASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIDNSRQYAANPFLQSVYQYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length714
PositionTail
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.04
Grand average of hydropathy-0.446
Instability index70.17
Isoelectric point9.34
Molecular weight77401.75
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30189
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.95|      14|      19|      64|      81|       1
---------------------------------------------------------------------------
   66-   79 (26.86/ 8.40)	PPAGAAGMGMASRA
   83-   96 (26.10/ 8.35)	PMGGLSGLGPMGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.93|      20|      23|     260|     280|       3
---------------------------------------------------------------------------
  260-  279 (40.30/12.73)	GFSHMLLDPPPTGPPSSPGG
  282-  301 (30.63/ 9.03)	GLHAELSDPLFAWLGQAPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     450.54|      86|     223|     302|     387|       4
---------------------------------------------------------------------------
  100-  173 (89.79/32.21)	.............................................PGQQ..........PP.......GTSGM.AP..HGM....TGVSAATQQ..TQL..QLQQ...MAlKLQ.MQQQQQN...............QQQIT.ASQLATPQQ.QLKAMQVSAL.KTQSQ.....
  176-  256 (76.32/26.30)	..............................................CAL..........RAtreienlPAQ..HSALLTVVEQvyEIVQCIKVR..AQL....VQ...QQ.Q.A.AAAAQAA...............QAQAA.QMGASG....Q.YTPASMPVlPCVP..STKH
  257-  386 (125.18/47.75)	GihgfshmlldppptgppsspggpaglhaelsdplfawlgqapasPTSF..........PP.......PTQAFRAPLTHTLQQ..SNIQPFHEQ..SNLANRVVQ...YA.QLV.ALGKEVN...............QSSIT.MMSSPSPVQ.QVQTPQSMPP.PPQPQLAIEH
  387-  520 (62.40/20.19)	P........htdthsraysgpapspssflpspspqpsqspaaartPQNFsvpspgplntPG.......NPNSVMSPASSS..Q..SEEQQYLE........KLKQ...LS.KYIePLRRMINkidknedrkkdlskmKSLLD.ILTDPSKRC.PLKTLQ.......KCEIALEK
  528-  612 (96.85/35.31)	.............................................PT............PP.......P.....PPVPPTKQQ..YLCQPLLDAvlANIRSPVFNhslYR.TFV.PAMTAIH...............GPPITaQMASPRKRKyEEDERQTIPN.VLQGEVARLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      25|      25|     654|     678|       5
---------------------------------------------------------------------------
  654-  678 (46.09/28.89)	DYPDQSPLWIDNSRQYAA..NPFLQSV
  680-  706 (37.67/22.16)	QYMTSKLLQLPDKHSVTAllNTWAQSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30189 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVNQSSITMMSSPSPVQQVQTPQSMPPPPQPQLAIEHPHTDTHSRAYSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
2) PTSFPPPTQAFRAPLTHTLQQSNIQPFHEQSNL
3) SQASVSDPMNALQNLTGGPPAGAAGMGMASRAPGAPMGGLSGLGPMGQQMSLPGQQPPGTSGMAPHGMTGVSAAT
350
302
48
464
334
122










Molecular Recognition Features






MoRF SequenceStartStop




NANANA