<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30151

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLLAVHADVDALLAHLVAAGHRVLPCKQGFLLLDTADDSGDWAAGWVHKAVSRPLVFCHLQQLPTAQSVFLRPSLWPTPYLPLPDTVCAPRAPIVLLPHATPAYFLSAYTGPTAALVRQFSDAFNGLHIRPSFVIGWISVENKRGEDKGITVIYPSQLCLAFAPAFNRPLLDHTPDLPPPLQPSPKLPHAPHRPSLLGSPSTELSALRALTLSKSKNIRSIAAQVSAYVDHVARDRERERERLKRERTVPQTPSAPPYPSPPQAETTATIPGNTSPVLSPPPPPPSLPPPLRTATTTPPATTKNPLTPLHAPPPPPPPPPSYDPFSYLSDMDFGMDFGMMSMSMNQSADSNPNPSRTSDRSTFGIDFDEVTDDDFNFFDQPSTITSPPLLDDVHASGPGPPQPTPHSQQMATPVFTPDSVVPLFPSPDIKSPEPVPSHVHLDVSKVFSPPADQPQKGFDPIPFAHYHRVADGKYAPTGKFGLPSPPPDDLSWRNRYNALTDPRVGIVRKLKRKRMTQGGRKDIKQNPWVVEFEEWAAHRPFLDGSDDEDSQSDEEMEDEDTPATSRPNTPPPSYLPLGPTLLQTHFHHAHLLPLSKPLRPPGSSISGSASQAAATPAPIASVPTPVSPAAGLGLTAEKWRMLEVVVNVLAKEAIENAVWRDAWSASNAFAKGMEGKRLTEIWVSDVKMVEKTFESLDDVECLSMSDLFGSARTMETPKITLGKGEAIINILPPALRFWEKLGLGPKNGEKNATVYTLFADDGDQYRHREVVSWLEGVRTAYEVKHLGMLEPGTYVKGGLFQLKFDVSFRKHFDSFISNISGSTTPIILFLVVPVTLMTLSSTIFRRILSSMQKSMRAHPSSQVIVQLIPEHVINYMENDPASTSQLESFCMNLYNRILVPTEQPLARRFSPDNTPISIKALLQKPIFTLARPTYNTVTYTRAAFSSLDVLDRYTLLHVGYRISSCGKWAMAACVDQRGEAWEHAVWLLNQDVDGEGNGCSASLGGSEEMLVVKRVWDFVAGFAVRADVEWRIVISKLGIMEEAEFAAWSTLLPTVLAMDYPRSVHISLFCVDPDTPWLFTKFDTTMFGSRSDDNKHNTVFSDISSTTYAVNLNIVLPIATPPSQLDIGISLPYVADPSGTSNDGDPESTDSPPTTATHSNTPPTVPSSIPSKIGLMPKSTSCLIRVPRSAPLTSITMLHIHLLSTYSTSLREEDNNNNNNNNNSHNNGNNSKTDMLDPGVILSDVTHNFYELSVLAQLQWKLSGTDGGGGGGGDGRSGGGGDARFKTGANPILPVHLAMVDVMGQVTDGADCTEIDS
Length1317
PositionKinase
OrganismAgaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392) (White button mushroom)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Agaricaceae> Agaricus.
Aromaticity0.08
Grand average of hydropathy-0.278
Instability index50.73
Isoelectric point5.72
Molecular weight143679.16
Publications
PubMed=23045686

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30151
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.13|      29|      29|     256|     284|       1
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  260-  288 (55.66/16.05)	SPPQAETTATIPGNT....SPVLSPPPPPPSLP
  289-  317 (33.14/ 6.81)	.PPLRTATTTPPATTknplTPLHAPPPPP...P
 1144- 1170 (37.33/ 8.53)	GDP..ESTDSPPTTA....THSNTPPTVPSSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     315.88|      70|     249|     122|     195|       2
---------------------------------------------------------------------------
   45-  103 (81.11/35.84)	..........GWV....HKAVSRPLVFCHLQQLPTA..QSVFLRPSLWPT.....PYLPlPdtvcaPRAPIVLLPHAT..PA
  126-  195 (134.35/71.04)	GLHIRPSFVIGWISVENKRGEDKGITVIYPSQLCLA.FAPAFNRPLLDHT.....PDLP.P.....PLQPSPKLPHAPHRPS
  408-  437 (37.18/11.16)	..............................QQM..A..TPVF.......T.....PDSV.V.....PLFPSPDIKSPEPVPS
  438-  487 (63.24/23.55)	HVHLDVSKVFSPPADQPQKGFD.PIPFAHYHRVADGkYAP.........TgkfglPS.P.P.....P...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     513.17|     171|     250|     693|     884|       3
---------------------------------------------------------------------------
  693-  884 (255.66/233.55)	FESLDDVECLSMsdLFGSARTMETPKITLG.....KGEAiiniLPPALrfWekLGLGPKNGEKNATVYTLfADDGDQYRHREVVSWLEG..VRTAYE....VKHLGMLEPGTYVK.GGLFQ..LKFDVSFRKHFDSFISNisgSTTPiILFLVVPVTLMTLSS......TIFRRILSSMQK.SMR.....AHPSSQVIVQL.IPehvinYMeNDPASTS
  944- 1141 (257.52/175.70)	FSSLDVLDRYTL..LHVGYRISSCGKWAMAacvdqRGEA....WEHAV..W..LLNQDVDGEGNGCSASL.GGSEEMLVVKRVWDFVAGfaVRADVEwrivISKLGIMEEAEFAAwSTLLPtvLAMDYPRSVHISLFCVD...PDTP.WLFTKFDTTMFGSRSddnkhnTVFSDISSTTYAvNLNivlpiATPPSQLDIGIsLP.....YV.ADPSGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.81|      13|      19|     601|     615|       5
---------------------------------------------------------------------------
  601-  613 (22.20/13.64)	PGSSISGSASQAA
  618-  630 (23.61/ 7.86)	PIASVPTPVSPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.65|      12|      27|     326|     337|       8
---------------------------------------------------------------------------
  326-  337 (24.38/12.29)	SYLSDMD.FGMDF
  355-  367 (17.76/ 7.12)	SRTSDRStFGIDF
  368-  378 (19.51/ 8.49)	DEVTDDD.FNF.F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.27|      31|     311|     228|     259|       9
---------------------------------------------------------------------------
  228-  259 (53.58/34.53)	YVDHVARDRERERERLKRERTvPQT..PSAPP..Y.P
  541-  576 (44.68/23.84)	FLDGSDDEDSQSDEEMEDEDT.PATsrPNTPPpsYlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      13|      19|     639|     655|      10
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  639-  651 (22.53/21.24)	WRMLEVVVNVLAK
  659-  671 (25.06/11.76)	WRDAWSASNAFAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30151 with Med13 domain of Kingdom Fungi
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