<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30148

Description Uncharacterized protein
SequenceMNISSAHADPMRIYRAKRDSAKPRVTKNYNILGFISSGTYGRVYKAQSREPDARIHAIKKFKPDKEGDVTTYTGISQSAIREIALNREISHENVVALKEVILEDKSIYMVFDYAEHDFLQLIHHHSQTLRTSISFPVLKSLTFQLLNGLLYLHSCHIIHRDLKPANILITADGVVKIGDLGLARLTYSPLQALYTGDKVVVTIWYRAPELLLGAKHYNKAIDIWAVGCVVAELASLRPIFKGEEAKLDSKKNVPFQKDQMLKIFEILGTPDERDWPGVKDMPEYPNMKRLDPYTNRLRDWCSNRMKSQLGYEFLKQTFVYDPDKRLTAHAALKHKWFQEDPIPTQNAFESLQAHQHPPPRRITYDDAPSMMPLPTQAQATQNVAQAQATQVHALSMSHSMSAKSMSGRGSAGSVGTGVGTGGAIGNGTAGGGRARKKARVG
Length441
PositionKinase
OrganismPhanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Phanerochaetaceae> Phanerochaete.
Aromaticity0.08
Grand average of hydropathy-0.402
Instability index37.85
Isoelectric point9.49
Molecular weight49260.90
Publications
PubMed=22937793

Function

Annotated function 
GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30148
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.54|      20|      24|     273|     293|       1
---------------------------------------------------------------------------
  273-  292 (41.76/29.09)	RDWPG..VKDMPEYPNMKR...LDP
  298-  322 (30.78/14.65)	RDWCSnrMKSQLGYEFLKQtfvYDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.83|      14|      29|      12|      25|       2
---------------------------------------------------------------------------
   12-   25 (23.87/13.77)	RIYRAKRDSAKPRV
   42-   55 (23.96/13.85)	RVYKAQSREPDARI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.68|      23|      23|     348|     370|       3
---------------------------------------------------------------------------
  326-  345 (26.95/15.75)	....LTAHAALKHKWFQEDPIPTQ
  348-  370 (42.19/28.68)	FES.LQAHQHPPPRRITYDDAPSM
  373-  396 (29.55/17.95)	LPTqAQATQNVAQAQATQVHALSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.55|      12|      22|     164|     175|       4
---------------------------------------------------------------------------
  164-  175 (20.89/14.31)	PANILITADGVV
  189-  200 (21.67/15.10)	PLQALYTGDKVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30148 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PTQNAFESLQAHQHPPPRRITYDDAPSMMPLPTQAQATQNVAQAQATQVHALSMSHSMSAKSMSGRGSAGSVGTGVGTGGAIGNGTAGGGRARKKARVG
343
441










Molecular Recognition Features






MoRF SequenceStartStop




1) PMRIYRAKR
2) RARKKARVG
10
433
18
441