<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30142

Description Uncharacterized protein
SequenceMPGRKDENNLPLYESQPPSWLPKSHATADLGYPGFFPTKPGQDEDVLSDSRVRSGFVLGHQVSAETFSAQAIINENLNAGDTLNQLESLINEVFKRRADRIPPIPSSTFRLPTRVTLNEARKQTWFADLANPDVPLHRLRKNVPHLAKGHDMLDLLHQNNVAIPRAIWFLRVSGANETTGLRGGKGKGSYNPTQYSIDWANVMTGYMKKQLADIALPSAPRPGLNIKQTFKGVLADAEGREKWISRFSYCLMLLRTFYAEGLVDHRTFLVWFVHQMGVCNLAQAGFLSRLADEYLNPILTSRALARPFVDACLNKLVEIRNTAQEYLADTEKQFCVILQRICLALPDAFVCPRMWLAHSAMIADVMAADIIQFPPGIECSTDRAVREIRRSISDNLFDIKKRNEAILFLDPPSKGVGRLYMTIMDVKLLNSISAMTDMTTVSFFQNELDNTPAFQEKLDMLLTWSVTTLQYGDHRPFAAVTLIRLWRDRACERATRRGTETPSDFLQDQLFDWLDISEVAEEAKHLRSIALLYGELIKEELFSYSKYIQRLIARGEPGLSFTETTISRHRQFLRWIPLHKSVSPEVNQRKVTLYDLKARSTPEDTAEREIRQEIRLILPELFGGETDFDVTTSVTLLDQSKILMNAPRFEQARSIRDWFLPKLRELACRPHSAVTGSSLLRIYCISVEVMSYVKCFDSLLDFTLWVLANTKYPELLVAIIDTLHRFATIWSCMNIKRDIVLALDSAHQASKSRGIQSRGLLSLLVEFDRDKSYLSPASRERIDSDLCHFTLALRPVTEHPESVPDRLTEILLMAADTAADAPSLLANGLWIKYRTSLDWAWKVWDNAIASLRQVPLMNSDTTQRKACALRYGMFLWQVNQHLPDGLDGDVQRWFAGPGQNEIAALTAEAWQVVTVSLLYLCIHGALKSTTILTGVVYPAWQLGATESTPEVHVFLTSANNLFRQLLLQETPNTTGIPPVDLFDVQCLQTRRRTVYEEPHFSCLVKSIPLLILLENKLDIPQEIRAEFTSLRHQLCHGNQFRQGAYRSLDVIRAAFEDYPPLPEQSSANLGQNIIAGLRTILGDNVDEKNMYHWPEVTCLLSPWKIVATTIQMQFSVKQLGKALTQEATHEAASSNLNKLSIMLFHQSMTSEEAYYVGEMAQGADSTVASKFIANGFKCINELLQEFISEQMTKALDKLRRVGEVLRALVYIAQPFRKEGALVLYLDPVVQDDFVAILHNKLSEIITTLEPSASAQIDQSAQISQQIILLVRLLQFDLGFRGAWTPKMKDLSGGFIRNLFHLALYFGAPDHLNPVVYPLLVDTLLFIIDGIVSNATNSNITSEIPQPAKPLSFDPFRHYPNTLTSDIPTDLPLEYRKQILSLLSSLSTSCAVTNLVASNLLQEQPVVNQPWEWIENLDEASTLDGSSKDEDLDRQEKARLKTRYLVKNSGSLSLENFRAQMTGDGVVELLATDYDAQALNDIRTFEDGLAAEGIFARDWRESRIDVDESISSPTSVSSGRAMQSQSAGGGAGSGDGDQESGSSFSHTKTERKLTPMRASPASSIVSRSSAKGSTSSWKQQSPTMRLVGEGNDAEGPSRGVAKRKMDDGDDEVEAIERPVPSHTAPPTKRARAGAGKTTGKTAGKPRAKKR
Length1649
PositionKinase
OrganismAgaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392) (White button mushroom)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Agaricaceae> Agaricus.
Aromaticity0.08
Grand average of hydropathy-0.229
Instability index45.33
Isoelectric point6.18
Molecular weight184725.65
Publications
PubMed=23045686

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30142
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     251.05|      92|     170|     452|     553|       1
---------------------------------------------------------------------------
  452-  517 (84.25/58.34)	.....................................................................................................PA.FQ..EKLDMLLT.WSVTTLQYGD...HRP.FAAVTLIRLW.....RDRACERATRRGTETPSDFLqdQLFdwlDIS
  518-  553 (13.04/10.96)	EVAEEAKHLRSiaLLYGELikeELFSYSKYIQRLIA................................................................................................................................................
  619-  686 (64.17/32.09)	....................................rgepglsftettisrhrqflrwiplhksvspevnqrkvtlydlkarstpedtaereirqeirlilPElFG..GETDFDVT.TSVTLLDQSKilmNAPrFEQARSIRDWflpklRELAC.RP..HSAVTGSSLL..RIY...CIS
  688-  754 (89.58/48.27)	EVMSYVKCFDS..LLDFTL...WVLANTKYPELLVA......................................................................iiDTLHRFATiWSCMNIKR.D.............IVLA.....LDSAHQASKSRG...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      21|     174|     224|     252|       4
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  224-  252 (31.09/46.37)	LN....IKQTFKGVLADAEGRekwisrfsYCLM
  313-  337 (32.11/23.51)	LNklveIRNTAQEYLADTEKQ........FCVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.84|      74|     261|    1010|    1136|       5
---------------------------------------------------------------------------
  364-  440 (117.66/66.82)	DVMAADIIQFPPGIECST....DRAVREIRRSISDNLfDIKKRNE..AILFLDPPSKGVGRLYMTIMDVKLLNsiSAMTDMTT
 1049- 1128 (117.18/17.99)	DVIRAAFEDYPPLPEQSSanlgQNIIAGLRTILGDNV.DEKNMYHwpEVTCLLSPWKIVATTIQMQFSVKQLG..KALTQEAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.02|      88|     100|    1432|    1531|       6
---------------------------------------------------------------------------
 1432- 1531 (122.55/146.90)	DrQEK....ARLKT.RYL..VKNSGSLSLENfRAQMTGDgvvellATDYDAQAlNDIRTFEDGLAAEGIfARDWRESRI.DVD...ESISSPtsVSSGRAMQSQSAGGGAG
 1536- 1634 (130.46/108.42)	D.QESgssfSHTKTeRKLtpMRASPASSIVS.RSSAKGS......TSSWKQQS.PTMRLVGEGNDAEGP.SRGVAKRKMdDGDdevEAIERP..VPSHTAPPTKRARAGAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30142 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVDESISSPTSVSSGRAMQSQSAGGGAGSGDGDQESGSSFSHTKTERKLTPMRASPASSIVSRSSAKGSTSSWKQQSPTMRLVGEGNDAEGPSRGVAKRKMDDGDDEVEAIERPVPSHTAPPTKRARAGAGKTTGKTAGKPRAKKR
1504
1649










Molecular Recognition Features






MoRF SequenceStartStop




1) VAKRKMDDGDDEVEAIERPVPSHTAPPTKRARAGAGKTTGKTAGKPRAKKR
1599
1649