<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30137

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMASTQAHSYEVALFGEFFAKDLPAILNRITLRSESAHQMHAREVVFEPFDVSHQRETGSEPVLLRARKELLEPDPKWILFSCLKPESVRVYPEATVRPCALCQVTGDALSFASALGYVRRSQIYKRGYVFRRGMLVIQMFQQEQVDLKTQKPIPAHTDTLWEVEVKTAMPVRTQDTPMKAAIDAVLEVQLLMKGLLDLRRQDV
Length203
PositionHead
OrganismPhanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Phanerochaetaceae> Phanerochaete.
Aromaticity0.08
Grand average of hydropathy-0.182
Instability index47.75
Isoelectric point7.75
Molecular weight23171.62
Publications
PubMed=22937793

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30137
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.57|      24|      24|     152|     175|       1
---------------------------------------------------------------------------
  152-  175 (44.53/30.56)	PIPAHTDTLWEVE..VKTAMPVRTQD
  177-  202 (36.05/23.58)	PMKAAIDAVLEVQllMKGLLDLRRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.35|      10|      23|      39|      48|       2
---------------------------------------------------------------------------
   39-   48 (18.71/14.43)	MHAREVVFEP
   64-   73 (16.64/12.04)	LRARKELLEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30137 with Med18 domain of Kingdom Fungi
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