<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30137
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MASTQAHSYEVALFGEFFAKDLPAILNRITLRSESAHQMHAREVVFEPFDVSHQRETGSEPVLLRARKELLEPDPKWILFSCLKPESVRVYPEATVRPCALCQVTGDALSFASALGYVRRSQIYKRGYVFRRGMLVIQMFQQEQVDLKTQKPIPAHTDTLWEVEVKTAMPVRTQDTPMKAAIDAVLEVQLLMKGLLDLRRQDV |
Length | 203 |
Position | Head |
Organism | Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Polyporales> Phanerochaetaceae> Phanerochaete.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.182 |
Instability index | 47.75 |
Isoelectric point | 7.75 |
Molecular weight | 23171.62 |
Publications | PubMed=22937793
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30137
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.57| 24| 24| 152| 175| 1
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152- 175 (44.53/30.56) PIPAHTDTLWEVE..VKTAMPVRTQD
177- 202 (36.05/23.58) PMKAAIDAVLEVQllMKGLLDLRRQD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.35| 10| 23| 39| 48| 2
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39- 48 (18.71/14.43) MHAREVVFEP
64- 73 (16.64/12.04) LRARKELLEP
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