<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30124
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSALYSTSGLSGSSNAPHQAANARDTPHSMSEILLQPLNDLQALTHTLFHSLSPTQTRPPPVPPITAFLEADAALASAVKLARKHQIKHRKNERLKEEFLALEEHWRDIIKELEQGKRELEVILTEGEERMKNIDAAKADAVPASIPYPELLQYAHSLSAFTSAPPNMPELAPGQPPPPLFFPPFPNEEKMRRGHMNAEAPLGSLGETHEVGQARTVSPHPVERPQHMGGPNPFRMDHRMPQQQVFDLDLDLNPDL |
Length | 256 |
Position | Middle |
Organism | Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Polyporales> Phanerochaetaceae> Phanerochaete.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.589 |
Instability index | 59.26 |
Isoelectric point | 5.79 |
Molecular weight | 28421.88 |
Publications | PubMed=22937793
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30124
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 126.27| 39| 115| 19| 64| 1
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19- 64 (66.33/40.25) QAANARDTPHSMseillqPLNDLQALTHTL..FHS.......LSPTQTrPPPV..PP
135- 184 (59.94/25.20) DAAKADAVPASI......PYPELLQYAHSLsaFTSappnmpeLAPGQP.PPPLffPP
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