<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30123

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKPALQPPDSTGLSALSQHPQRISLSSPILASAIDLPPNPLISCSVFIATRAPTPTEQLTAIENARRRIVADYTPLPMAQSLLPSVHVTKDRVSLYLFAFGSTMDASAAQMPLSLGTRKTRHLLQLKMLLCESGAVLYRQSFTYISCVRVAERNGPCTMGGPGLLAHAKRCIQKFDTYSFTPDGIYPCSLSCATQRVPCAVCIQQREASSFATPSSQASPTCSLPRKPLRLPLVQFIQAVRDRIIDDIVRSSSETSERWTGRLQGGFLLSPLSPADDGEWGAEWEHYGRSRPFVHCELQISLSQTRLVILPILRTTQYLPLTTSLSLPTGTPIVLLPHGTPAFYLNTYSGALGNLTHQFEDALFGLGVGNWKSAPVNESTNSPCYLIAWVSVQNKQGEEKGLPVIWPTTLSVLPDGTCPQARHKLAYLPDLPAQLLASPPAVPAQAPPITFPLSALNSSVSPLPSASDVSPSPWMTTRERPIATRREFSCPLSNHSPTSDSLRAFRSLTIGERNIHAVARDVSTYVDSIAKERERERERLKREREGSSSRVPTSPQKQEFAQSPIVAAGHEHGLTPAGVQQASLYATEDRVPLKREESPIAFVSWDAITNASTGDTGEPLPPIGVASPAGISAGMLSTDIADKLPGTVGLPSGEVEMVVDDDVAKEFDTFNGLDASWPQSSTDLMNMDMPLDHYNFAMDMSGTNNNESTNINVDDGFGMFTDDDFDFFDRPQPSSSHTSRSALPLSAAANPDAPMSAALRGLQTSGPGPPVTLNGEHPAPWTAHFGLEGLTPRSLPASTPGLLPAPELVPSTPLQTPSVQSGPATPTVMLDHHIHIRRSSTSSQGSINFDPIPFSPAHKAKDGKYTVGKFALPTPPPDDVERIWPHSRRSQEPSLPPMGWRFSYGSATDPRIAVVRRLVGAKRKRLGEDENGRDGRMSPAWMHEHEEWAHSPLSQEGLEGDSRTDSDLDVDEDAAYEDRSALTSSRSFTPPLSHLPLGPSLVATAFHHSYLLPLSTPLRPPGAVTVHGNVDIGAGPMSVPTPVSPAATLGTASERTRSLESTVQFLVKELVENPMWADAWHANLSVHSSFFPSSYIWLGDIRCVMTMLHTVSGMHSPIELGNAYNSDTDLSFRELDPPMFAVGKSDALMQVLPTALRFWEKLGLKPRSGNKDVTAFVFFEARNEAGEVELSDWLESLGQTYMTKNFGSHIAGRAAGCTRDGLVPVQFDSFRKTLVSFMPGLPDFGTSVVIYIVIPTHMITLASASLRQIFSAIRKIKKERAQRDRSLLFHLVPEPFASGSLDNPAMRYLSFETIVEAVYDRIPVLTRGALVAQGDRVQGDRVQGDRMQGDHMQALFQEPSFVLARPLSRRPTFHLEARTSTLDVMERFSILHVGYRVSPCGKWLLVACVDQRGEMHELKAWLVPGDNLEAFVVKSVWAMALNIAGRVNVEWRIAITKHGAMNELELCTWRSQLSTAEHASPPSEVLVLVADHGRPWTFLLPEHAEYQKPPKSPYRVHKQSPGTVLHEISSTSFFVYSGAPSSLLLDAPYPLSPSHPFVPDVEEECAPPCYIVRPLASATVLRVPTGIDHTSVSMLHIHLLHKTHLPQLLSLPTEHAALKDIARNYHDLSVLARHRWKFRANPVLPFHLAALEVISTALACDEYLTD
Length1666
PositionKinase
OrganismPhanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Phanerochaetaceae> Phanerochaete.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index53.42
Isoelectric point6.17
Molecular weight182268.01
Publications
PubMed=22937793

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30123
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.42|      28|      31|     171|     198|       1
---------------------------------------------------------------------------
  156-  184 (39.58/18.82)	..PCTMGGPGLLAHakrCIQKFDTYSF.TPDG
  185-  216 (43.23/21.28)	IYPCSLSCATQRVPcavCIQQREASSFaTPSS
  405-  430 (33.61/14.79)	IWPTTLSV....LPdgtCPQARHKLAY.LPD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.28|      23|      24|     757|     780|       2
---------------------------------------------------------------------------
  757-  780 (39.47/24.84)	AALrGLQTSGP.GPPVTLNGEHPAP
  783-  806 (38.81/19.71)	AHF.GLEGLTPrSLPASTPGLLPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.77|      18|      32|     462|     489|       3
---------------------------------------------------------------------------
  455-  472 (30.89/ 8.00)	ALNSSVS.PLPSASDVSPS
  483-  501 (27.88/26.30)	ATRREFScPLSNHSPTSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      14|      22|     615|     630|       4
---------------------------------------------------------------------------
  615-  630 (23.09/17.49)	DTGEPLP.PIGVasPAG
  639-  653 (21.36/ 9.26)	DIADKLPgTVGL..PSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.01|      51|     464|     891|     948|       5
---------------------------------------------------------------------------
  223-  259 (49.97/24.10)	...SLPrkPL............RLPLV.QFIQAVRDRIIDDIVRSSSETSERW
  570-  595 (31.67/13.12)	HEHGLT..PAGVQQASLYATEDRVPLKR.........................
  891-  941 (93.37/74.16)	QEPSLP..PMGWRFSYGSATDPRIAVVRRLVGAKRKRLGEDENGRDGRMSPAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     223.95|      75|     488|     942|    1027|       6
---------------------------------------------------------------------------
  945-  978 (29.17/11.28)	...............................................HEEWAHSPLSQEGLEGDSrTDSDLDVDEDAAYED
  979- 1021 (57.89/27.21)	RSALTSSRSFTPPlSHLPLGPSLVATAFHH...SYLLPLSTPLRPP...................................
 1470- 1535 (96.82/38.25)	RSQLSTAEHASPP.SEV.....LVLVADHGrpwTFLLP........eHAEYQKPPKSPYRVHKQS.PGTVLHEISSTSFFV
 1536- 1568 (40.08/ 9.92)	YSGAPSSLLLDAP...YPLSPS.......H...PFVPDVEEECAPP...................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.19|      28|     231|    1186|    1213|       8
---------------------------------------------------------------------------
 1186- 1213 (51.64/37.41)	GEV.ELSDWLESLG..QTYMTKN...FGSHIAGR
 1413- 1446 (35.54/23.10)	GEMhELKAWLVPGDnlEAFVVKSvwaMALNIAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.20|      42|     480|     326|     367|      10
---------------------------------------------------------------------------
  326-  367 (76.58/36.64)	SLPTGTPIVLLPHGTPAFYLN.........TYS.GALG......NLTHQFEDALFGLG
  811-  868 (56.62/25.27)	STPLQTPSVQSGPATPTVMLDhhihirrssTSSqGSINfdpipfSPAHKAKDGKYTVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30123 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDFDFFDRPQPSSSHTSRSALPLSAAANPDAPMSAALRGLQTSGPGPPVTLNGEHPAPWTAHFGLEGLTPRSLPASTPGLLPAPELVPSTPLQTPSVQSGPATPTVMLDHHIHIRRSSTSSQGSINFDPIPFSPAH
2) GAVTVHGNVDIGAGPMSVPTPVSPAATLGTASE
3) GKYTVGKFALPTPPPDDVERIWPHSRRSQE
4) PSASDVSPSPWMTTRERPIATRREFSCPLSNHS
5) RLVGAKRKRLGEDENGRDGRMSPAWMHEHEEWAHSPLSQEGLEGDSRTDSDLDVDEDAAYEDRSALT
6) VDSIAKERERERERLKREREGSSSRVPTSPQKQEFAQSPIVAAGHEHGL
722
1022
863
464
917
526
858
1054
892
496
983
574










Molecular Recognition Features






MoRF SequenceStartStop




NANANA