<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30094

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGLLGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGLGTGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGTTLSIHETCFTQTADSLFFMHEDLVKAQAPMFDVPSAIEVMLTGGYHRLPKCIEDIGSQNRLSPDEEKRALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVLRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASENPFTVLYAILHEFCISLAMDTIIRQANALRQGRWKDAIRSELISDSATGQIGNASLMQLVQDGELDSSGFKIPGLKVNYWLDEKSTSTAEPDSSPFIKIEAGQDMQIKCQHSSFVLDPFTDKEANLSLDLSCIDVEQLILRAITCNRHTRLLNIQRQLCKNVQVSQSPKDVILKRDVTAAKDPKKNAEKKGSSDCFGNEVLQVRAYGQAYISLGINIRSGRFLLQSPENILPPAALMDCEEALNKGSTSATEVFSSLRTRSILHLFAAAGRFFGLKVYQQSQGTLKIPKAILDGSDFMIMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDASDKTNANADAKEAIRFNKINVGQMQILKSESTTNPFDVKLQALQSIMSSADIMDSDLPVQNGIEPLPLLPACSPSFSSIVDEVFEYERGSTAAQNHSILPSSLPATPHLSSLSVGIQGVNARAVSPMHDGGLSHTQANNILKVHPSVSLNSYFPSNFRHLHDVNKSLQLVPSSNSNSNQIPVQSSHSGSLGNSPSDHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPIIPSLQGLQPSDPIKRRKISESARSPLPLQAYTSNLQSRASLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSNLWLTLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELNGGNTTTQWGVGIRIANTSEMDSHISFDSDGVVLTYNTVEADSVQKLVSDLRRLSNARSFACGMRRLIGVKIDDKLDDNQLSTEMKSQSVNKGNSDASDKLSDQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSSMPKQANNIPTQGPLANGSSSSSIHHAPVPSNAAAAHLSSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNAAQASGHLNNNAGAPQTAPSASRLSATPGVSLSRPTSGVANHVAASLSRAGNAMLASSALASGIGGASVRLAPGAGLPVHMKGEINTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSASADNTESTLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNNHIAFLAMDGSHGGRACWLQLEEWERCKQKVSRAVETVNVSAVAGEVGQGRLRMVAEMIQKQLQHCLQQLRDGPLSAGSTAS
Length1737
PositionTail
OrganismSetaria italica (Foxtail millet) (Panicum italicum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Cenchrinae> Setaria.
Aromaticity0.06
Grand average of hydropathy-0.153
Instability index49.68
Isoelectric point8.09
Molecular weight189417.04
Publications
PubMed=22580951

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30094
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     443.39|     146|     466|     589|     763|       1
---------------------------------------------------------------------------
  589-  744 (214.40/139.00)	DASDKTnANADAKEAIRFNKINVGQMQILKSESTTNPFDVKLQALQSIMSSADIMDSDLPV......QNGIEPLPLlpacsPSFSSIVDEVFEYERGSTAAQNHSILPSSLPATPHLSSL...SVGIQgvNARAVSPMHDGGLSHTQANNiLKVhPSVSLNSYFP
  775-  929 (228.99/143.52)	SHSGSL.GNSPSDHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPIIPSLQGLQPSDPIkrrkisESARSPLPL.....QAYTSNLQSRASLTYGDVLAERNNCVPATIYASVLLHVIrhcSLCIK..HAQLTAQMDSLAIPYVEEVG.LRT.PSSNLWLTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.80|      17|      17|    1188|    1204|       2
---------------------------------------------------------------------------
 1168- 1184 (28.64/17.37)	SSMPKQANNIPTQGPLA
 1188- 1204 (28.84/17.54)	SSSSIHHAPVPSNAAAA
 1207- 1220 (23.32/12.57)	SSHNLHAAAMLS...AA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.00|      31|     404|    1227|    1270|       3
---------------------------------------------------------------------------
 1233- 1269 (46.56/57.25)	LPFDVSVVLRgpYWI....RIIYrkkFSVDmRCFAGDQVWL
 1640- 1674 (56.43/32.01)	LPYCVSVRLR..YSFgdnnHIAF...LAMD.GSHGGRACWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.79|      12|      21|     944|     955|       4
---------------------------------------------------------------------------
  944-  955 (22.55/14.06)	GKAGSMSWDVRI
  968-  979 (23.24/14.74)	GGNTTTQWGVGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.54|      14|      18|    1413|    1427|       5
---------------------------------------------------------------------------
 1413- 1427 (19.35/15.94)	WVpLAALKKVLRGIL
 1434- 1447 (25.19/14.88)	WL.FAQLPELLKEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      14|      18|     983|     996|      12
---------------------------------------------------------------------------
  983-  996 (26.22/18.14)	NTSEMDSHISFDSD
 1003- 1016 (23.46/15.43)	NTVEADSVQKLVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.40|      16|      22|    1040|    1056|      13
---------------------------------------------------------------------------
 1040- 1056 (22.28/22.10)	DKLDDnQLSTEMKSQSV
 1065- 1080 (27.12/20.50)	DKLSD.QMRKTFRIEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.62|      85|     261|    1285|    1374|      16
---------------------------------------------------------------------------
 1285- 1374 (131.03/81.37)	LPCPQFRPFiMEHVA..QGLNALEPNFMNAAQASGH..LNNNAGAPQTAPSASRLsATPGVSLSRPTSGVANHVAASLSragNAMLASSALASG
 1548- 1636 (131.59/68.56)	LPISVLREF.LKLIAwkKGFSQAHGDIATAQRARIElcLENHSGSASADNTESTL.AKSNIHHDRAHSSVEFALTFVLD...HALIPHMNVAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.49|      13|      24|    1375|    1387|      18
---------------------------------------------------------------------------
 1375- 1387 (23.03/11.91)	IGGASVRLAP....GAG
 1396- 1412 (18.46/ 8.02)	INTAFIGLGDdggyGGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30094 with Med14 domain of Kingdom Viridiplantae
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