<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30061

Description Mediator complex subunit Med12
SequenceMTSRPGPTAAQRTTAGGLPRPPTQVRPSVQQHVYSANARPPADVIDLTADEAKPPAADAPPKHHPPKQTTAADDARWPSQDNQFAVQDGFSKPPPRGRPQISFEDISEVGTSGFGRAASVALRATAISNSGSLPFPPRPGFRVHKRQSQGARPASSPAGGVKKDAAQRNGVVEPPPDAVRVPRGKTVDFYPWAGNHPEDGLSAEVVKVGYFDDRKGQVDLNAGKAHVGPQIKNKSTLQTLSSLFIQVLEKRQASGRVREPSTFKPPPRITVKDTQREEWLRDLANPSLPPKRRIPHGIRGKLLLEQCLSKNIPIARAIWLAKCVGANEMRAWMRKGASSTGGMGGEVKWVREWTVFVEQFVDSTISICGQDGWRDKMDYTIRLASQLYTERLLDQDHYLDWLLTSLESTEVERLPIWFLMVQIYWQDIVALRRRGRRLTEALLLHLDSMESADKVEAENPLILRSRRLITTLLMGHRNCMVIPRTWRKYRHFFDNMLKGSVHPALQSAIRSVIRRNERLTGWSHNPAQTHQSPQKSVLSALDEISLDLNLNEFSAQCVALMPDAQGLAVTVLQWACSLYREGSHRLYVAVRLLRKWKSKGADIDSAILAVLSDGQKLKGIKHRDFFRLVAELVRSKHFSVGRYLQWLIASGSLSAGGDVTKSEACSVRLIAEIPLQGLPEHVLNLRQSLLQTNLQNGANEALDLMDDHSVIFKQLWAIFDQDIGDEITFDIPFANLSTGVRLEISHWLRQELLARLAPTLEDDEMRDDFVLTAPRFYAIRDVVEQLEDFTILADILGLAMQSNDLMVFAAIADTLNHHHRTFAAIGALRPLFNNLIELYGKARLDKPLERSFLLALADLCCRLQTEPNLVVQLTSDITRLEQRSAVAACSPASDNMADFHGGKMDFDEEIDRILASGTSMDENMVARVFAKVVTRIEEQIGKESGRCSKFGQWLQRLKAFDDKTFDRHMSDTISSMMLSNGQSLLHILPCAVGSGSLSLDNFISFSETTIGFLRKTNVSAAANASLHVLDAILPMEGLQGFGLVQEIYRYRIEQEKLCQSSQGVALQLLRQAIELCSDSKDSKQPIQLESLLRNQRLLKVLRYHACRNAHEFCVAMGISPPSENADAAMALDEKRSTLIKTLFDALMDPSSSLGLTKLDAEDQASTLVNAADDLSVPFCQLELQLLFKIQVLSDEEGEIGVADAIIQAVKEAVENDKSIWSDLLTGLDAEMTRKVKPISRTSPGRLMLMRSQIREYAETHILSAVSSLAKARTVNEELLLLTSREDHQRMLHRYLSVLNLTAWSIDDKAQSQICAAILEKLRTLLELLSASSQSGQSVESREEITKLRQGSTAAIALSPWICAMLHLIVLHKSICQPSKASTSHQASLLWTLRTFLLHPELQSFPQTTEYILDVAASLSDDLPEEARAQLLRYESTKATHDPRVAFLLGLPAAIQDSWLGLITPIQPQSTGNTTSSASNNPASAAAAARGTAAQHQHQGFWQAQAQRTQAQQQRLGAAGTGAAAQAGGMNSNSTQPVEYGKPVPYHLRRWEILPDSTSGSGPNDTALSLTLFDAKKV
Length1577
PositionKinase
OrganismMacrophomina phaseolina (strain MS6) (Charcoal rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Macrophomina.
Aromaticity0.06
Grand average of hydropathy-0.261
Instability index46.59
Isoelectric point7.26
Molecular weight174649.20
Publications
PubMed=22992219

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30061
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.18|      10|     171|      92|     105|       1
---------------------------------------------------------------------------
   92-  105 (16.09/16.58)	KPPPRgrpqISFED
  264-  273 (21.09/ 9.32)	KPPPR....ITVKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     741.97|     257|     470|     579|     891|       2
---------------------------------------------------------------------------
  353-  543 (112.44/59.93)	..........................................................................................................................................WTVFveqfvdstisicGQD.GwrDKMDYTIRLASqLYTERLLDQDHY...L.DWLLTSLEST.E.....................VERLPIWFLMVqiywqDIVALRRRGRRLTeALLLHLDsmesadkveaenplilrsrrlitTLLMGHRNCMVIPrtwrKYRHFFDNM..LKG.......................SVHPALQSAIRSVIRRNErltgwshnpaqthqspQKSVLSALDE
  607-  891 (405.99/360.59)	ILAVLSDGQKL.KGIKHRDFFRLVA...ELVRSKHFSVGRYLQWL..................IASGSLSAGGDVTKSEACSVRlIAEIPLQGLPEHVLNLRQSLLQTNLQNGANEALDLMDdhSVI.......FKQLWAIF............DQDIG..DEITFDIPFAN.LSTGVRLEISHW...LRQELLARLAPTLEDDEMRDDFVLTAPRFYAIRDVVEQLEDFTILA.....DILGLAMQSNDLM.VFAAIAD.......................TLNHHHRTFAAIG....ALRPLFNNLieLYGkarldkplersfllaladlccrlQTEPNLVVQLTSDITRLE................QRSAVAACSP
  910- 1118 (223.55/127.50)	IDRILASGTSMdENMVARVFAKVVTrieEQIGKESGRCSKFGQWLqrlkafddktfdrhmsdtISSMMLSNGQSLLHILPCAVG.SGSLSLDNFISFSETTIGFLRKTNVSAAANASLHVLD..AILpmeglqgFGLVQEIY............RYRIE..QE.....KLCQ.SSQGVALQLLRQaieLCSDSKDSKQPIQLESLLRNQRLLKVLRYHACRNAHE....FCVAM.....GI............................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.32|      12|      31|      20|      32|       3
---------------------------------------------------------------------------
   20-   32 (19.31/12.60)	RPPTQVRPSvQQH
   53-   64 (24.01/11.65)	KPPAADAPP.KHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.69|      62|      68|    1276|    1339|       5
---------------------------------------------------------------------------
 1276- 1339 (98.02/77.65)	EELLLLTSREDHQRMLHRYL.SVLNLTAW..SI..DDKAQSQICAAILEKLRTLleLLSASSQS.GQSVE
 1342- 1409 (87.67/62.70)	EEITKLRQGSTAAIALSPWIcAMLHLIVLhkSIcqPSKASTSHQASLLWTLRTF..LLHPELQSfPQTTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.86|      17|      66|    1138|    1161|       9
---------------------------------------------------------------------------
 1138- 1155 (23.57/25.00)	LIKTLfDALMDPSSSLGL
 1167- 1183 (29.29/10.97)	LVNAA.DDLSVPFCQLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.39|      11|      22|      40|      52|      12
---------------------------------------------------------------------------
   40-   52 (14.97/14.45)	PPADVidLTADEA
   65-   75 (20.42/11.60)	PPKQT..TAADDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30061 with Med12 domain of Kingdom Fungi
Unable to open file!