<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30057

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVSMDGNGVHGAGLGKLDDRAPTAPPKLNGDVPPSHLDGPSNMNGNSITNGAASLPQSPSTDLSQPLPALQDVSELYLPFGKLVERVAQETNVSLGEVLDRMSNLQISPAPTMNGINGHMTNGSAPLSKENEEKKLMMLNWAWAEREKFIKLLVLSKWSRNCDDVSKMIGLNVWLMEQMHQYEDAPHWIGQLKRNTESAKAPNPDLKTALEVLSTGKVPWVPDLGYIPPEPLTPQQMLKTVTNLNALLAIRINLHEELPRQMKDWSIASGRATFRVPSEFELDVSIADEDPSSPFFIVDVRFLFSPKPEVPDAWFRDFVEPEANVVLANSGLNGIYDWLHGFVLTHKLTTLRMQAHELSQTAWANSLRVQQIHRSLTVQYWTGTSGAKSWIEIGISSGNPKDGKRSWRGPSPPQLSLRWTRKGMPVENIPVKFDWTDLSLERMLKSIIALHISFILESIRDQLSLLSQKQSGLSMKAETSDSEPTDCCLSIRPGSMSKATEIRIDPISGGLSLRPATHFSLALERDIKDIALEAAPRIEGLICNDLRVRIDKEAQNVGWTRLRHINITPDAAGASVRQKVVARSFYRCQNWKSRWVLGLTVNLDGESWWLMELSNENIGNSILESIPLLGASPSERRHSVSHQFLRALEQFACAQFTYAIAVKELRRLQVPNALRTINDQKRKKDSTGRPVPQVTPALFIKSGPLLGEKDSRNNWAGDILRLQHKGLDTKTGCIVHAVKGQMSQGHVDFNLVSSHAGDVSFNSDGTFEVRLRTPFGEPFLEKIINRLKRIERLGRIVEIAKDQKLRCDHISLSRVVFRYCGNYKADIRFPEGSPVELHIAPNNPHRRMATFLKQALNNRDSSKGFAFFMKILSQTMPLMRGFESLEGSAPGPASISQPYVNPRSLDWYRLCYENPVTTFDIRLRTRHDAMEWHIHDSTNQQNNPRSPDFATALKDFLRQRGDKWLGVRTGIIAEIEGVEDALMKLDEVVKRFQAPVTDRPEGGGAPVQQNAGSGQNNRPHPQNQPRPQSQQQPIKPDPEIIMLD
Length1047
PositionTail
OrganismMacrophomina phaseolina (strain MS6) (Charcoal rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Macrophomina.
Aromaticity0.07
Grand average of hydropathy-0.433
Instability index49.78
Isoelectric point8.67
Molecular weight117263.41
Publications
PubMed=22992219

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30057
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.54|      68|     470|     217|     311|       1
---------------------------------------------------------------------------
  133-  204 (111.59/90.85)	ENEEKKLMMLNWAWAEREKFIKLL..VLSKWS....RNCDDVSKMIGLNVWLMEqmhQYEDAPHWIGQLkRNTESAKA
  238-  311 (103.95/68.19)	QQMLKTVTNLNALLAIRINLHEELprQMKDWSiasgRATFRVPSEFELDVSIAD...EDPSSPFFIVDV.RFLFSPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.81|      18|     471|     217|     235|       2
---------------------------------------------------------------------------
  217-  235 (34.52/23.33)	STGK.VPWV.PDLgYIPPEPL
  689-  708 (25.29/11.76)	STGRpVPQVtPAL.FIKSGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.64|      21|      21|     487|     507|       3
---------------------------------------------------------------------------
  487-  507 (40.19/26.76)	PTDCCLSIRPGS.MSKATEIRI
  509-  530 (32.45/20.12)	PISGGLSLRPAThFSLALERDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.54|      30|     149|     745|     776|       4
---------------------------------------------------------------------------
  745-  776 (49.09/36.98)	MSQGHVdfNLVSSHAGDVSF.NSDGTFEVRLRT
  898-  928 (54.45/34.09)	ISQPYV..NPRSLDWYRLCYeNPVTTFDIRLRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.93|      19|      38|       1|      19|       6
---------------------------------------------------------------------------
    1-   19 (36.14/19.20)	MPGIVSMDGNGV.HG.AGLGK
   40-   60 (26.79/12.46)	LDGPSNMNGNSItNGaASLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.06|      34|     435|     541|     581|       8
---------------------------------------------------------------------------
  541-  581 (46.23/52.28)	IEGLicNDLRVRIDKEAQnvgwtRLR.HINITPDAAGASVRQ
  978- 1012 (54.83/37.26)	IEGV..EDALMKLDEVVK.....RFQaPVTDRPEGGGAPVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.53|      16|      26|     393|     418|       9
---------------------------------------------------------------------------
  393-  410 (27.30/28.02)	WIEIGISSGN.PkdGKRSW
  422-  438 (29.24/ 7.65)	WTRKGMPVENiP..VKFDW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30057 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGIVSMDGNGVHGAGLGKLDDRAPTAPPKLNGDVPPSHLDGPSNMNGNSITNGAASLPQSPSTDLSQPLP
2) VKRFQAPVTDRPEGGGAPVQQNAGSGQNNRPHPQNQPRPQSQQQPIKPDPEIIMLD
1
992
71
1047










Molecular Recognition Features






MoRF SequenceStartStop




NANANA