Description | RNA polymerase II transcription mediator |
Sequence | MADLLTQLQDAVDQLANQFVASLFYVHKHHDYQKLNPNDTIRQEPKNEEGVAPMDPDVTPDPADVFKAAQRELAQDLILKEQQVEYLISSLPGLGNSEKDQEDMIRMLEEELKVAEDERREALMEKEEVLGRLEGVIRGIKRP |
Length | 143 |
Position | Middle |
Organism | Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.687 |
Instability index | 41.73 |
Isoelectric point | 4.55 |
Molecular weight | 16366.25 |
Publications | PubMed=22876864 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP30037 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) EPKNEEGVAPM 2) PADVFKAAQRELAQDLILKEQQVEYLISSLPGLGNSEKDQEDMIRMLEEELKVA | 44 62 | 54 115 |
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