<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30036

Description Transcription mediator subunit Med12
SequenceMTTRPSVARQPPQHSLSSTGPTQRPPPLRAPSQQFSSSSPTRRGNESFVDLTFEGGDAARPRLGTSRLRVEISTDPRQSDIKSPKPFLAATPTWMPTLPPRGRPQLPFDVPSAGQRGAQEGGQQAITIKPMPLPVRPGQHAPPTSEKQRPVPTSTTAKKDARPKPYNLEVPAIAPHYSPNGHADFYPWTGNHPEDQFSETAIRQGYFDKSHTSQNETGSARSTIFPALKHKSGLQTLSAVFTNVLAQRRAHGQITSGSTFKPPPRVTVTDTKREMWLRDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGASGTFAMGGEAKWIRDFTVCVEQFLETIIGTCGEKDFKARIGYAIRLATNFHAEYLLDREHYMDWLVSSLENSPQTKLPMWLLVTQIYWKDLLKFRKYGRRLVAALMNQLAETLNHPDHDLMAPLVDRLKFLLNGLMTSNIHNFVSPKVWNTHRDILMANLGSEDLLLKSVLGAIDRRNSRFVAAGASKEPNSRQRLIALLDGTLFKPSSTDLPRLCWDIDNDKELLVSTVLKWAASSHRPGHAKVYVAARILRSWSKIGPDVTGSILKFLDSSICDSIRCKSAFYHLVSELARSEHFSTPRYLQWLIARGGIYSTADLDPNGPASTRLLAELPMANVSDSIIELRAALLSRGDLSADEEDDQVHDCMVFMNRTLPGMQTGDDLDLEPNEYSATSGLSKLPSDLSRTIRSELGFWLRQKVKLQMIQPTIPPLDDWDVSLLKGGTSAMTGSEFNTVRRYLEYLEDYSVLADVLKIATTSNDAEVLASCADTLDLHLKTFAAIGALNSLFDILMSRLRALTEENVSVLRTFLVSLSDLASRLPNQHTVAQQLARELARSDRKTAADACSPVSDHMAIVETAEVDFTDEIEKVLASGNSMDQATLERLFGRIILRLQESWEKSPEQQRSCALLLTRLRTFDAKQFDLLMAAWVSKALPMQSRPNMMQVFGPLISFGCLAFRDVLLGCGASEKEASVGSSYATGTSSELLCLLVAPCNLPEIMTHEETYRLRVKQSHMQKDFPSDVTSVIRQAFAESYSGIQPAGSHALEVKTLLGGVDMHELYQFLVLHDPVAFTQKLAVPLLQTSTAETAAAINTVIDKLMLAGSPAEPITTELLLNITDDLSLPFCQIKLASMLQAHDTTMEGGEAGQPDHLVAFDSAIESAVNSGKTSWASIIPLLDTSIAQHLRRRADVQFLSLFPSPKTPNNEGFLMENRIRRAENLLRIIDATAHGISTSSPDPSNTSLASDMVTTLNGIRLLFANTQSQEVKDIVISKWLPLLLSFMTIHVSAFEATKQGNESRAKATLALAAVFLQLQAIDLSTQAIVTLVEQTFDLALNLVDSLPEDLRLQCVRSIRTTTSNPQIPYLFSIAANPTEWLVLSQKEKAPVIPGQSNPDGNGRQAEKEKLAPFHLRRWELLGEPTPNVGENDTSLSLTLFGARRG
Length1495
PositionKinase
OrganismMarssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index45.97
Isoelectric point7.22
Molecular weight165216.73
Publications
PubMed=22876864

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30036
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     315.63|      62|      66|     613|     678|       1
---------------------------------------------------------------------------
  513-  559 (61.45/28.25)	RRNSRF...VAAGASKEPNSRQRLIALL..D..GTLFK..........PSST....DLPRLcwDIDND
  560-  613 (70.86/36.75)	..KELLVSTVLKWAASSH..RPGHAKVYVAA..RILRSWSKIG..PDVTGS..ILKFLD.S..SICD.
  616-  677 (102.57/56.90)	RCKSAFYHLVSELARSEHFSTPRYLQWLIAR..GGIYSTADLD..PNGPASTRLLAELPMA..NVSDS
  680-  743 (80.75/42.19)	ELRAALLS.RGDLSADEEDDQVHDCMVFMNRtlPGMQTGDDLDlePNEYSATSGLSKLP.S..DLSRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     174.07|      44|      70|       1|      44|       2
---------------------------------------------------------------------------
    1-   34 (53.19/27.08)	.....................................MTTRPSVAR.QPP.QHSLSSTGPTQRP..PP..LRA.PSQQ
   35-  107 (52.24/26.45)	FSSSSPTRRGnesfvdltfeggdaarprlgtsrlrveISTDPRQSDiKSP.KPFLAAT.PTWMPtlPP..RGR.PQLP
  108-  140 (45.81/22.20)	FDVPSAGQRG........................................aQEG.GQQAITIKP..MP..LPVrPGQH
  143-  171 (22.83/ 6.96)	.........................................PTSEK.QRP.VPTSTTAKKDARP..KPynLEV.P...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.78|      38|      93|    1133|    1171|       3
---------------------------------------------------------------------------
 1133- 1171 (57.08/36.24)	VPLLQTSTAETAAAiNTVIDKLMLAGSPAEPITTELLLN
 1229- 1266 (66.70/38.72)	IPLLDTSIAQHLRR.RADVQFLSLFPSPKTPNNEGFLME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.82|      43|      97|     802|     852|       4
---------------------------------------------------------------------------
  445-  497 (62.28/30.67)	QLAETLNhpDHDLMAPLVDRLKFLLnglmtsniHNFVSPKVWNTHRDILMANL
  809-  851 (72.52/56.81)	KIATTSN..DAEVLASCADTLDLHL........KTFAAIGALNSLFDILMSRL
  962-  982 (22.02/ 6.24)	...............SCALLLT.RL........RTFDA.....KQFDLLM...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.20|      22|      98|     304|     336|       5
---------------------------------------------------------------------------
  272-  297 (30.24/24.86)	KREMWLRDLANPTiSLRRLSRsipHG
  315-  336 (38.96/15.31)	ERAVWLAKCVGAN.ELRSFRR...KG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.24|      17|      17|     207|     223|       8
---------------------------------------------------------------------------
  207-  223 (29.06/17.66)	FDK.SHTSQNETGSARST
  225-  242 (23.18/12.52)	FPAlKHKSGLQTLSAVFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.08|      18|     242|     772|     790|       9
---------------------------------------------------------------------------
  772-  790 (29.01/24.83)	DVsLLKGGTS...AMTGSEFNT
 1015- 1035 (28.07/18.23)	DV.LLGCGASekeASVGSSYAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.18|      32|     544|     364|     411|      11
---------------------------------------------------------------------------
  376-  408 (52.06/58.83)	RIGYAIrLATNFHAEYLLDREHYMDWLVSSLEN
  413-  444 (57.12/25.15)	KLPMWL.LVTQIYWKDLLKFRKYGRRLVAALMN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30036 with Med12 domain of Kingdom Fungi
Unable to open file!