<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30033

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSELGPREITGRAASRALSSKKLVSDWASKQDNSETATRTITVCFCSGACPTTRSCRQAVELPSEFQIPTAIDDKEVLLLLVIHVADAREEEPGDGVLFSCSNPTGLNETLPSPVVLSDVPDVGTSASAEPEEVPALVLLLPLLRQCASAPAPAPLHALAARLTTLIPPIPAPPFEAGLEAAQISSLLPEDVAKPLRECLAGLMADLPLPQAPAPDVMFGNGMGDVGVGMPMGQMGVQMPVSAMPLRQAAAFLIEYGARAHTWERNPEYASVPRLPHPHHRHIIQLGRALTTDSQAFIVALFDAAADRVLTSWSHSPSAAVRPYVFFTEALPVMLRWWRDNADPKWPYPADLQGALQGVITTHSQQLSNWFQAVNSIYTAKFSQSEPDEEGYVQPDGWSLLSLEATAVRRYVSLGLLEEEAATELIGSPVKPASSCESLMERLATTSPSHLPALETFITYASGATSSTASLGAEVASKPAPENLFVRLAGSPSLMVLIAAYISPSSLLDIITENLLDRVEDPAVRQEDPQSSLIRFGAANVQLPLPHLLWNARRVSNLEDLSEDERGHLNGWVKALFGSDGIDDEILLKTSPQGLCRLASTLVQQSIVAASSGQIDLDTLHSGLSYFAQPLLSWCLGSVVGWLCAEIERLGQLSGVHLNVLQTLVLDSAFPEPLLRANAHAMNRLLEPTSGLEPVIQSSGFDAIAVRARLQAVGGPDGSALLPDPPYLSPLPTLRSEIQAVRHIDIATQGWESRLLDAVQAALRAEGSLRVLDALLPDIVYPSVVDVEDPITQVVALICALHLQGIPLSVALVNGLVPSLFAPRSPFVPASIQPHLIGSSANGVNNATPPLPYAAHTLHRLLRSTILAVATSDDTLADQLAQYLAEEIAYQSTRPVNQPKTKRMPKGLGPGAAPDPGLVDEQKALLDELISKFEADDEFKGRFPTFVNTMAPKAINGEVANGDGDVQMS
Length969
PositionTail
OrganismTrichosporon asahii var. asahii (strain CBS 8904) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Trichosporon.
Aromaticity0.05
Grand average of hydropathy0.047
Instability index54.81
Isoelectric point4.82
Molecular weight103626.95
Publications
PubMed=23193141

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30033
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.31|      54|      60|      77|     135|       1
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   77-  134 (80.90/43.16)	VLLL.LVIHVADAREEEPGDGVlfsCSNPTGLNETLPSPVVLSDVpDVGTSASAEPEEV
  138-  192 (86.41/37.83)	VLLLpLLRQCASAPAPAPLHAL...AARLTTLIPPIPAPPFEAGL.EAAQISSLLPEDV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     667.66|     169|     174|     521|     689|       2
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  251-  325 (44.97/17.47)	..........AFLIEYGARAhtwernpeyasvPR.......LPHPH....HRHIIQLgRALTTDSQ..........AFIVA.......LF.DAAADRVL....TSWSHSP..SAAVRPYV....................................................................................................................................
  342-  505 (165.18/85.17)	..................AD............PK.......WPYPADLQGA.....L.QGVITTHSQ..QLS....NWFQAvnsiytaKFSQSEPDEEGYVQPDGWSLLSLEATAVRRYV...SLGLLEEEAATELIGSPVKPASS..........CeSLMERLATTSPSHLPA.LETFityasgatsstaslgaeVASKPA.PE........................NLfVRlAGSPSLMVLiaayISPS
  521-  689 (283.41/151.75)	DPAVRQEDPQSSLIRFGAAN............VQ.......LPLPHLLWNARRVSNL.EDLSEDERG..HLN....GWVKA.......LFGSDGIDDEILLKTSPQGLCRLASTLVQQSIVAASSGQIDLDTLHSGLSYFAQPLLSWCLGSVVGWLC.AEIERLGQLSGVHLNV.LQTL.................VLDSAF.PE........................PL.LR.ANAHAMNRL....LEPT
  693-  865 (174.10/90.19)	EPVIQSSGFDAIAVRARLQA............VGgpdgsalLPDPPYL......SPL.PTLRSEIQAvrHIDiatqGWE.............................SRLLDA.VQAALRAEGSLRV.LDALLPDIVYPSVVDVEDPITQVVALIC.AL.....HLQGIPLSVaLVNG.................LVPSLFaPRspfvpasiqphligssangvnnatPP.LP.YAAHTLHRL....LRST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30033 with Med5 domain of Kingdom Fungi
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