<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30029

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDPKSKNGSHTNHDRDQRPNGVNGGSHTSDKMQDKSEARAEPQQNMTPPSPAAPSLSNGKLADHARRENGGNGGPWDVQAQMDLLPQEIIHMTEGYQPLSKFLQRVVQKTHTELINTLSDLEQMPTPASALNGNSATDDSSQENVQKKMRLMNYATSAHESLTKALVITGWSRKAEDVSKLIDIRLHLEAQKQLYTTAIEAMASNKRALHNFRLPNPDFKTALEALTTGKSSWMPDLGYIKPPPLTAKELLRQMEKLNTLLSMRLNLDDYDKIPPQFKNFTIQSGRATFKVPGEFELDLTVANEDPGSQYWFIDFRFLFRPSSSNMNLGIRNYIESRVNETLFTDGLSGCYKYLHELVLTYKIKEFRRQGDNLARSIWTDTLSVENLNRPISIQYWVGRYSGQPMNGKSSSARPSKSWIILGVHSGKVPGRCPSPKDTSRLFIRWFRDFKEVKDPDIKLDDVDISTESLLKTVIGKHIDHILTSIFEKLLAKPLYASRELEISLHISVDDPADSELKVQLTQEHRLSIKIEPMSGRFVLGPVSKQYSQTEFDLNRRSQDPATDGHIYIERLRSMLLTEDLQVRAISVGWTRVNKPGLSQESMAEIVGKEALPTVWFRRPGWEKDWYLVVTQSMGGEKWHLIKTAMVPHTLKKEVLGVGECIKLPIKSVSPITSYSFLSTLNIFTAGVVSHHINAKTLHARRVQHKSVKGKLAKSIALPSIYAKLSDLIPSKNRLSRTGMSWAKDVIKISFQGIEVIGQKPSEATESAISTSVTQASQSSAPVPQAPSVLIPPKSFNVDERSVLVTEARLIASLPKALLNIKDQVDKDIIFNAETASFAVRLRSKVGDSVIPDLVECLVRVERLVEFIQVLDTHKDTLTCDMVSLGKIVFTYQEVSSVSPLDASDAGIDTATKYSAAVDYSAADNTMALMLEGGNPHLRIADSLATILNGSEGLNGVATLLPLTLPVLRALDTMEDAWSAEELSGKGQVIVHARATDSYLIRYSLFPKSPLAASVSFNVKLRSRNSQPWWHVRRVATARNGEPDALEEDLAPLWALSPCPDWKGMRMSGVARNKSIENLLVKLDETVRRFALSGKNLNSAVSAPPPAQVQAPAPQKQIPTQNPRQQQQQQQQQQHQRWQPASNQGQSQARNPHNPHNREVVEID
Length1168
PositionTail
OrganismMarssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina.
Aromaticity0.06
Grand average of hydropathy-0.419
Instability index46.99
Isoelectric point8.96
Molecular weight130189.81
Publications
PubMed=22876864

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30029
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.91|      76|     233|     653|     793|       4
---------------------------------------------------------------------------
  425-  504 (119.81/52.96)	ILGV.HSGKVPGRCPSPKdTSRLFIRWFRDFK.EVKDPDIKLDDVDiSTESLLKTVIGKHIDHI.LTSIFEKLlaKPLYASRE
  659-  737 (115.11/163.25)	VLGVgECIKLPIKSVSPI.TSYSFLSTLNIFTaGVVSHHINAKTLH.ARRVQHKSVKGKLAKSIaLPSIYAKL..SDLIPSKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.89|      12|      17|     139|     154|       6
---------------------------------------------------------------------------
  139-  152 (15.76/21.91)	NSATddSSQENVQK
  158-  169 (21.14/ 8.99)	NYAT..SAHESLTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.52|      44|     233|     298|     352|       7
---------------------------------------------------------------------------
  298-  352 (63.80/89.90)	GEFELDltvanedPGS.QYWFIDFRfLFRPSSSNMNLG.IrnYIEsRVNETLFTDGL
  540-  585 (71.72/59.20)	GRFVLG.......PVSkQYSQTEFD.LNRRSQDPATDGhI..YIE.RLRSMLLTEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.06|      13|      22|     857|     869|       8
---------------------------------------------------------------------------
  857-  869 (21.19/14.39)	DLVEC.LVRVERLV
  880-  893 (17.87/11.07)	DTLTCdMVSLGKIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.36|      12|      17|      98|     109|      10
---------------------------------------------------------------------------
   98-  109 (21.85/13.04)	TEGYQPLSKFLQ
  117-  128 (19.51/10.91)	TELINTLSDLEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30029 with Med14 domain of Kingdom Fungi
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