<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30028

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTTLPSDFPISLRSWPSTNGNDELPSIISRINTERGGFRNITEESLRQEIIEEELNDENDNPSSSEDEEEPDRAKELNAAREAFVKDLEQAYQSAMLVLDLVSLLLSKDIPVQASLSLSQGLQSMVGTQTLGMGKLAASRITEAQKQDHKNVAKGWKTQFLDKAVDSILASATRLEKEIERETKYWEQVLAVSEKGWAVCRLPNQKHILGVRFGFSESSPAFRSRSLAALTRKPDGSISLDQGFADAEPKSLRVRIKVDGKVTGISRVPKAIPKDTPVEALILQSRNTIFAEELWQELNRESRAMEPVKSKDNTLIYELTAEKFMVLDLIPLGEESTEYSGPDGPLAQSLFFAFNILLSYAHRQAHRARSRVPPPISSERRITPPLNLFRPFIARAKHQERTAQMHALFRSLHHVLVSASLPHPPSYTLVPTVWPAPLSLPIAERTILALTERLEVIATFTVTPTTTIKVKAQTYSQPTIYTQYLLALSPADSPLQMTCPVVPRTESFLVVQEYMYYATSCALASIFVPHPFATPSPSQPQPGESITPLWTQTAHPNILKKSITSPSAAAAAKQKQLAISIRSSSPVGSQSKHTITILRVQWEFLRSESSEDEDLGWMVTSWANALADGEDVSMAGGEVAKGKVMKKAMPGENSYSWIEKSFPEGGAGEGDDEDEEVVEVVKSLVDVVRDAGEWSE
Length696
PositionHead
OrganismMarssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina.
Aromaticity0.07
Grand average of hydropathy-0.328
Instability index60.93
Isoelectric point5.45
Molecular weight77029.42
Publications
PubMed=22876864

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30028
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     179.96|      38|      38|     523|     560|       1
---------------------------------------------------------------------------
  416-  469 (30.02/10.47)	LVSASLPHPPSyTlvptvwPAPlSLPIAERTI...LALterleviATFTVTPtTTIK
  477-  512 (50.53/22.03)	QPTIYTQYLLA.L.......SP.AD.SPLQMT...CPV.......VPRTESF.LVVQ
  523-  560 (70.23/33.14)	LASIFVPHPFA.T......PSP.SQPQPGESI...TPL.......WTQTAHP.NILK
  563-  599 (29.18/ 9.99)	.....ITSPSA.A......AAA.KQKQLAISIrssSPV.......GSQSKHTiTILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.97|      25|      39|     617|     641|       2
---------------------------------------------------------------------------
  617-  641 (44.66/31.87)	WMVTSWANALA.DGEDVSMAGGEVAK
  657-  682 (39.32/27.11)	WIEKSFPEGGAgEGDDEDEEVVEVVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.10|      23|      45|      16|      38|       5
---------------------------------------------------------------------------
   16-   38 (40.61/27.61)	PSTNGNDELPSIISRINTERGGF
   62-   84 (38.50/25.77)	PSSSEDEEEPDRAKELNAAREAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30028 with Med17 domain of Kingdom Fungi
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