<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30022

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQRRVLRPLALPALLVAPVSVSSAQDAKLSAAFDVMGADWKNGRAEARVAAQAMGERPADWSVYFVPLRTNRVNKMLPTTVAAQWRGTPGVLTVWPTHLARPLAPVHKSAVQKPPKPGPGLGEPPALLAAANGAVRLFTSYTEPASDAVDEDADADETMEEVQPMEVEVEVEEVGDEESRRETGSDVDDLFSASPSPESEPEQPDEEPFIASAFTSPRGLELEVDDLFGADEPIEPDQKEEPEEEVKEEEQPEPVPEPELPEFEPPSRADTDMNDKNDVTEDDFNFFDSPAKQTEPTPAAVAEPTPTPTTVLPSVTEEPKPEDVTAEAPAPEPIEITSIADLPVPEVIEPVEPETQPEPEALEESPKLAVVHAPKKRTSIDIVPPAFAPLQLPKRPRMRFAYGLPSPISPASSTLRIELVERLREKSGQGKKYDYAQEWELSSESSDEEVDSAFTTGAPPTPSSSDDEDGTPAPRAASAAPPPAPDHEVMFDGMMCVGGEWVSLKDDPTLCSKLARAWAPAWVELPPEPPEYVPLSPEADAAPSAPSPDLEAVANAAVRNRFLRPLFTHPTPNETLMPAPLVKLGVPLAELTEAGQPAAASYALSPANVNVGLGGNVLQLSAAGLRYWRELGLMPAGGQKDVTAYVVCEPGEGERLAASFLRDIGDVYTSHLLGKHEAGTAEGTDGVIAVPPSDVPSVLSRLGNAVVYVLTYAARGSSVLPMLKENVHVVPVEAVRVGNLLPLAFEVYDGRTERVPRVQLRGRQLASTPPLPFHAFTLALPPQRPQLTMSWPQKSYDVLARGRQVHCAYAFAGAHVILTVVDGQGDALDLRVLPFTSTTEAIPRMWEIFTSLAEQRSRQYAMTITRVGLMSKAEIGGWKTLFPTAEGTITLLMAEPPAPSPLRPRTPVANIPPSTFADPSAAIVDETLAGSAAPLSARLAVELPPAPTPTASSASGTGEAYYPPASFVLSMANAAGTGASTATFHVLHTSEGTPGTVHESLAPRFYELTCLGRRRYALDALPIHLDAALKGAEAIEVVSAEA
Length1042
PositionKinase
OrganismTrichosporon asahii var. asahii (strain CBS 8904) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Trichosporon.
Aromaticity0.06
Grand average of hydropathy-0.260
Instability index59.59
Isoelectric point4.55
Molecular weight111360.03
Publications
PubMed=23193141

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30022
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.16|      36|      36|     188|     223|       1
---------------------------------------------------------------------------
  105-  141 (36.63/ 6.82)	PVHKS.AVQKP...PKPGPGLGEPPALLAA......angaVRLFTSY
  195-  231 (54.62/13.27)	PSPES.EPEQPDEEPFIASAFTSPRGLELE.........vDDLFGAD
  527-  569 (38.91/ 7.64)	PEPPEyVPLSPEAD..AAPSAPSP.DLEAVanaavrnrflRPLFT.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.28|      34|      36|     288|     322|       2
---------------------------------------------------------------------------
  236-  259 (31.29/ 8.43)	..........PDQKEEPEEEVKEEEQPEPV...............PEPE
  288-  322 (58.42/26.03)	D........SPAKQTEPTPAAVAEPTPTPTTvLPSVTE......EPKPE
  323-  360 (41.91/14.18)	D........VTAEAPAPEPIEITSIADLP...VPEVIEpvepetQPEPE
  434-  468 (29.66/ 7.55)	DyaqewelsSESSDEEVDSAF...TTGAPPT..PSSSD......D...E
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.95|      70|      86|     593|     678|       4
---------------------------------------------------------------------------
    6-   47 (49.12/21.57)	LRPLAL.PA....LLVAPVSVSSAQDAKLSAAF..DVmGADWKN...GRAEA.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  593-  624 (20.46/14.82)	....................................................rvaaqamgerpadwsvyfvplrtnrvnkmlpttvaaqwrgtpgvltvwpthlarplapvhksavqkppkpgpglgeppallaaangavrlftsytepasdavdedadadetmeevqpmeveveveevgdeesrretgsdvddlfsaspspesepeqpdeepfiasaftsprglelevddlfgadepiepdqkeepeeevkeeeqpepvpepelpefeppsradtdmndkndvteddfnffdspakqteptpaavaeptptpttvlpsvteepkpedvtaeapapepieitsiadlpvpeviepvepetqpepealeespklavvhapkkrtsidivppafaplqlpkrprmrfayglpspispasstlrielverlreksgqgkkydyaqewelssessdeevdsafttgapptpsssddedgtpapraasaapppapdhevmfdgmmcvggewvslkddptlcsklarawapawvelppeppeyvplspeadaapsapspdleavanaavrnrflrplfthptpnetlmpaplvklgvplaeltEaGQPAAasYALSPANVNVGLG..GN..VLQLSAAG
  628-  714 (90.37/70.48)	WRELGLmPAggqkDVTAYVVCEPGEGERLAASFlrDI.GDVYTShllGKHEA..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................gtaE.GTDGV..IAVPPSDVPSVLSrlGNavVYVLTYAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.04|      27|     376|     493|     520|       6
---------------------------------------------------------------------------
  493-  520 (50.10/39.86)	GMMC...VGGeWVSL..KDDPTLCSKLARAWAP
  868-  899 (39.95/25.82)	GLMSkaeIGG.WKTLfpTAEGTITLLMAEPPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.33|      18|      31|     901|     921|       8
---------------------------------------------------------------------------
  901-  921 (26.20/21.00)	PLRPRTPVaNIPPStfADPSA
  934-  951 (33.13/15.25)	PLSARLAV.ELPPA..PTPTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.12|      20|      85|     738|     757|      10
---------------------------------------------------------------------------
  738-  757 (34.71/18.71)	GNLLPLAFEVYDGRTERVPR
  766-  781 (24.08/10.52)	ASTPPLPFHAF...TLALP.
  825-  844 (33.33/17.65)	GDALDLRVLPFTSTTEAIPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.89|      13|      85|     176|     189|      11
---------------------------------------------------------------------------
  156-  168 (20.77/ 7.73)	DETMEEVQPMEVE
  176-  188 (22.11/15.42)	DEESRRETGSDVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30022 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKYDYAQEWELSSESSDEEVDSAFTTGAPPTPSSSDDEDGTPAPRAASAAPPPAPDHEVMFD
2) TSYTEPASDAVDEDADADETMEEVQPMEVEVEVEEVGDEESRRETGSDVDDLFSASPSPESEPEQPDEEPFIASAFTSPRGLELEVDDLFGADEPIEPDQKEEPEEEVKEEEQPEPVPEPELPEFEPPSRADTDMNDKNDVTEDDFNFFDSPAKQTEPTPAAVAEPTPTPTTVLPSVTEEPKPEDVTAEAPAPEPIEITSIADLPVPEVIEPVEPETQPEPEALEESPKLAVVHAPK
431
139
492
375










Molecular Recognition Features






MoRF SequenceStartStop




1) GKKYDYAQEWELSSE
2) IDIVP
3) LQLPKRPRMRFAYGLP
4) STLRIELVERLREK
430
380
390
413
444
384
405
426