<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30020

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMELSECPTNVIACSNFASVQYEYFESQTGSPGVTKQHLQRIERGWRHEGKLVHYDSSREGIWMFQTGGDTGPLIKHSDQCDVDIQGLGIFQKDKGTYEPASLARSSKQASNAITTPNTSSSPSSSSLENALRNVQALNARSVQTNSNLGLTQESSTPSPGAKTVFVSLKDIHEYFISSVLSSIVYFLCHDHDFIPLNSRTLIMPSSESLEPGVGLGNGIELATLDISLTSLGVLVIKAHTDTAPGLQTSVNTLIPGKPPAAVSLGAALWLAPSGSAARLYSVPDDKPLPGNLPVSQIQEVDSRLNGIDTLTITSWKSKCLEWLSTMGLESKTLEASGWLYVQIIGGHLPYFNADTQAIPMLEELAIVPWPAILCFQTSSTETQDSNIWISGSFSYRDPLLFAEEWFTSREERAATVSKRQKERQAHADALLREQADTDARALQSHTYYPAALRRSSNAGAMYPTPPDAPQPHIGATPSFDGNVSTPGNQSHAVAHDTSGIQPSNPIAADVDTDMWAASGKRQRMSSGNTYNDNDNDNDNDNENDNSNLFGDLGGDMFGTHITDDDFNFFDEPDLDEFDHKTLLPPPGKLPDVQNVVPLAKKSFLNDTMETLGPVVSEMSLKAQDDRLLEQKHEPNTKELKERKPQISIPDHANFKVETATLPPPSINLPFNKEIIFHRLAQESIVSRSHEQPRRKSVFNQVYFEDSLQSVNEKYGPRGQFNFTLQRKSPVENLVDGLPQTAYFTSRRKTHEKIVEVSKIAQILGEKETCNSPKIDDPMEYLTASVGGSPISEQDDSSHTTEEPLTSPTLGLKRKWEGDDKDDITSTFDALAMEFEHSAGTPQSVGGSQMHLLDADPAAWALNTYFSSPEPATEPNTLSDLECIAGAQVLADQAISGTLRLPGSATNEPAISLDMTFTTRQLIHRLSKAAKSCLKDGTTCTLRSFLDIQGIPALNQALRLPPRPMSIPRAPIDSRPNNIFPIPPPQIEVRRSESKLSILPASVPFWENLGLAPSTGTKDVDAVCVYPNFEGLAANATTFLDQMRSVYESSRFGIHDRLVTKDIGNGLLPYTIDLTSQNRMQHLTSLMETAARLSKNFASSPVSEKNFVVYFVYPIDNSVLLVHICSAFQHLFNLYRKALSERRANAANELVLQLVPLDFIASPTSMAIPLPSKCFQLSMEVYDRCMDFASSSSSPAIVLEQPLPRTIDFKINTNPSASLLHENTCLHIAYAHSIDDRWITAAWTDNRGTRQMTASYCLGRRCEPVTTPFVDIANEIWQTTLQVISGRKIHWRIFIAKIGVMDASELDFWTGLASTESNAQISLTLVTVQTDPSLRLLPPYVTLAPNGTAAQSVLTPVSTPQALQSSTGSPDNASTPVRGGVGTGPPAESSVEPDSDARLIDHTDQSWGAILSHRLNNSNSLMEVNPALISGYLLKRGGVNIDDPPIIMEVNILHSEVVGNPRTFHESLLRELLGYYRGLGTIARTRGLVDAVKDVRPWHIAAAEKAVKALYMSM
Length1513
PositionKinase
OrganismMarssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina.
Aromaticity0.07
Grand average of hydropathy-0.326
Instability index47.64
Isoelectric point5.25
Molecular weight165801.39
Publications
PubMed=22876864

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30020
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     701.33|     264|     292|     283|     573|       1
---------------------------------------------------------------------------
   78-  286 (107.62/53.09)	..............................................................................................................................................................DQ.CDVDIQGLgifqkDKGTYEPASLARSSkQASNAITTPNTSSSPSSSSLENALRNVqalnarSVQTNSNLGLTQESS..TPS.PGAKTVfvslkdiheyfissvlssivyflchDHDFIPLNSRTLIMPSSESLEPGVGLGNGIELATLDISLTSLGVLVIKAHTD.......TApglqtsvntlipgkppaavslgaalwlapsgsaarlysvPD.DK
  287-  576 (412.31/282.54)	PLPGNLPvsQIQEV.....DSRLNgiDTLTITswkSKCLEWLSTMGLESKTLEASGWLYVQIIGGHLPYFNADTQAiPMLEELAIVPWPAI.LCFQTS...STETQDSNIwisgSFSYRDP...LLFAEEWFtsrEERAATVSKRQKERQAHADALLREQ.ADTDARAL.....QSHTYYPAALRRSS.NAGAMYPTPPDAPQPHIGATPSFDGNV......STPGNQSHAVAHDTSgiQPSnPIAADV.........................DTDMWAASGKRQRMSSGNTYNDNDNDNDNDNENDNSNLFGDLGGDMFGTHITdddfnffDE.......................................PDlDE
  584-  747 (181.40/92.83)	PPPGKLP..DVQNVvplakKSFLN..DTMETL...GPVVSEMSLKAQDDRLLEQKHEPNTKELKERKPQISIPDHA.NFKVETATLPPPSInLPFNKEiifHRLAQESIV....SRSHEQPrrkSVFNQVYF...EDSLQSVNEKYGPRGQFNFTLQRKSpVENLVDGL.....PQTAYFTS..RR.................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.66|      24|      58|     784|     841|       2
---------------------------------------------------------------------------
  784-  807 (43.03/58.27)	SVGGSPIS..EQDDSSHTTEEPLTSP
  843-  868 (40.63/ 6.88)	SVGGSQMHllDADPAAWALNTYFSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.01|      21|     469|     760|     783|       6
---------------------------------------------------------------------------
  760-  783 (29.68/29.47)	AQILGEkETC....NSPKIDDpmEYLTA
 1216- 1240 (35.33/21.29)	ASLLHE.NTClhiaYAHSIDD..RWITA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30020 with Med13 domain of Kingdom Fungi
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