<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30017

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSYSRVPDGAQSPSGPPTQPPAALHQLPQPVASSSRNPQLGPNPYFRYPTPTPEQIDEELPPYWETENVALGPMLDRLSRKGYGDMKVLVEQTLPPLAMRQKPKQIIEYAKTTRQAVLKYLALLRWKASVDMPSAPTTAPPAAVGAHSFPTPHSNGESNDTSPSSLPIKKPEEQQRGKVTDARRIQQFLEHQNAQHEAAIAHIRHVTSMVETLRERNADLLTAMSLRSAGNYTRLPSMLEESFVPRPKLKPAKVLDTVEKLNEHLLYRLRCVDYLPPSLVVEKVADGRAYVRGGGEAGWRAQLTVAGFDDDARWWLTGVEWEWTAKGQKKGFAPDERQQILDMVNKDILEPRPIPEGKEGSVDAPLVRVTNFLQHLSLSYQLEVLFSQALTLSQQTYRNQLIVDIDRTKKELTLKYWVRPRQAAPGQKRPGGPSTPIVGGIITFAITESKTPINDAERLLREVSAGTDVPADRPVGLELSVKWTVGDAGTGGGLKAGNQMDGSLLRIDSVGLSMKEILGTATRAHASFIARSTFSPLLANPRLALDPLNLPKLIESESAARPVQFIIPLPPAQGAAHFTVSVSATTGLIEIEDSMKDSGQVLENKRLLQTKLATASVNDQKTRLADDLHRLITAVILETIEDKMRQLGMQPTRRIPLRSHELTKTDLQPSSTIFVPLAVSQSHYFVSKITPEGVAYELLWLLRVPMENGGYRMAVGDRTPIDLQKLMERRRTKAHKRARDEDEVQQASDAWNDAQDAQAQAVKCRFDVKAKDLRDMFFYCNALVAQTIVEQQLKDRGIPYIPRYPDESDFPAPFSRSALAGMVPYICVNASELFKDGRATEVAAPQVYFVLKDWWKGSKCSVETIVRLQQASMSNDEAATSGVDPASSSASRAEGIKYDQATSTVRFHAPNIAKCVPDFLEQWERLSKVIIVAGEVNRLNKTEAYRDVRMLSFDLCTATLQYWDGFQVAITYTPTSDSYEVPFFKGDESASPHQLLAPLLSHHLNELTAQPSYVRDALGSNGKQFISLLRATLPLLLEQEALRTQSASEFPALVVRSVFDYRFVWDQFGTTRFALDITLSGNCRSFLLSDGARPRPPSEQVDLSCGVLTPIPNFDRVVQKGYQAARLAKVATPASMSTPGAAVAMTPKTPKTPGAGTQGKDARTPKTPAKVLIANGRAVGMPLPPAIKLDNGTTLMCAATVLQDVLRAMVAEIETQVAAYQAK
Length1223
PositionTail
OrganismTrichosporon asahii var. asahii (strain CBS 8904) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Trichosporon.
Aromaticity0.07
Grand average of hydropathy-0.333
Instability index43.53
Isoelectric point8.65
Molecular weight134927.50
Publications
PubMed=23193141

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     197.44|      52|     429|     518|     569|       1
---------------------------------------------------------------------------
  518-  569 (85.70/54.87)	LGTATRAH.ASFIARSTFSPLLANPRL.ALDPLNLPKLIESESAARPVQFIIPL
  955-  999 (71.64/44.55)	LCTATLQYwDGFQVAITYTP........TSDSYEVP.FFKGDESASPHQLLAPL
 1018- 1054 (40.10/21.40)	LGSNGKQF.ISLL.RATLPLLLEQEALrTQSASEFPALV...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.79|      54|     429|     140|     311|       2
---------------------------------------------------------------------------
   20-   85 (84.74/46.86)	PPAAL..HQLPQPvASSSRNPQLGPNpyfRYPTPTPEQ.................................................................................................ideeLPPYWETENVALGpmldRLSRKGYGD
  140-  173 (42.97/230.70)	PPAAVgaHSFPTP.HSNGESNDTSPS...SLPIKKPEE...............................................................................................................................
  275-  296 (23.09/ 0.00)	......................................qqrgkvtdarriqqflehqnaqheaaiahirhvtsmvetlrernadlltamslrsagnytrlpsmleesfvprpklkpakvldtveklnehllyrlrcvdyLPPSLVVEKVADG....RAYVRGGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.69|      56|     700|     422|     490|       5
---------------------------------------------------------------------------
  422-  490 (80.78/81.27)	QAA.............PGQKRPGGPSTPIVGGIITFAiTESKTPINDAERLlreVSAGtdvpadRPVGLEL..SVKWtvgDAGT
 1123- 1193 (86.90/53.73)	QAArlakvatpasmstPGAAVAMTPKTPKTPGAGTQG.KDARTPKTPAKVL...IANG......RAVGMPLppAIKL...DNGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30017 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DMPSAPTTAPPAAVGAHSFPTPHSNGESNDTSPSSLPIKKPEEQQRGKVTDARRIQQF
2) MSYSRVPDGAQSPSGPPTQPPAALHQLPQPVASSSRNPQLGPNPYFRYPTPTPEQIDEELPPYWETENVAL
3) TPGAAVAMTPKTPKTPGAGTQGKDARTPKTPAKV
131
1
1138
188
71
1171










Molecular Recognition Features






MoRF SequenceStartStop




1) PNPYFRYPTPTP
42
53