<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30012

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVVGSEQKANPADVVLVVEATANLSAYIDVLKKYYIIPSLEVFNGGPPDPTDIGHDYSCSLYNLVTFFSADVIPDTTSRCSGVTTNIHEFITWLDDLPLIGGGGESCSHITEGLSTALHVFDDLQKIRIDIGLPVQRHCILVCNSPPYNLPSQEGVRYVGYMADQLASMMAKRGIHLSIISPRKIPALQKLYEESTLPTDMSAPVKDFTTDPRHLVLLHGFQLEERAHSPAGDHVNIEKPAENKNPSSPAPPSFAPSTGFSPAPSLSEDSTEFKKPNTTSGGTPFSTQDSIASSMPSLPSPQQPQMSQPSPSQGISMQHSPAMPPMQQNPPQQQPQQQPMVSQPQVTNQMPPQSQYDPMKMQNMMPNDMQNRSTAMATNPINQPVFSQPTMDQQPNVNMPAQPGQPNPMKDRKIIWQGILEWQEKMKAGGPQTPKVNRQLQCHLSIGQTDPDINAMNWPKVLIMQLIPQSLLNSTQLQPLFKNSRQVAFHFGSQNLDDLRNLYKVMGTGFAGCVHFPAGSQCEVRVLLLLFSNKRRAFIGLIPNDQTAFVNGIRSVIYSHKIRQQQQQQRPDQQPQMPQQTGFPGPQQTMPNQPVQNPQGAQFGVQQMPQVSMQNPMMTQQQANMQQQGQRQPQMIITQGRGGQILHQGHQQVMGGGQVLQGNMPQMAQQGPSSAPQGGNMFDDLNMEFL
Length690
PositionUnknown
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.06
Grand average of hydropathy-0.537
Instability index65.15
Isoelectric point6.28
Molecular weight76135.69
Publications
PubMed=22992520

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30012
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.07|      17|      17|     567|     583|       2
---------------------------------------------------------------------------
  567-  583 (33.59/ 8.64)	QQQRPDQQPQMPQQTGF
  587-  603 (28.56/ 6.33)	QQTMPNQPVQNPQGAQF
  608-  624 (28.91/ 6.50)	MPQVSMQNPMMTQQQAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.22|      23|      24|     323|     345|       3
---------------------------------------------------------------------------
  323-  340 (37.09/10.59)	.....MPPMQQNPP...QQQPQQQPM
  360-  385 (32.15/ 8.11)	KMQNMMPNDMQNRStamATNPINQPV
  659-  681 (38.98/11.54)	VLQGNMPQMAQQGP...SSAPQGGNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.34|      17|      24|      80|     100|       4
---------------------------------------------------------------------------
   80-  100 (28.36/37.89)	CS....GVTTNIHEFitwlDDLPLI
  107-  127 (26.99/21.00)	CShiteGLSTALHVF....DDLQKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.76|      29|     147|      37|      65|       5
---------------------------------------------------------------------------
   37-   65 (54.75/31.27)	IPSLEVFNGGPPDPTDIG...HDYSCSLYNLV
  185-  216 (46.01/25.17)	IPALQKLYEESTLPTDMSapvKDFTTDPRHLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.36|      16|      24|     251|     266|       6
---------------------------------------------------------------------------
  251-  266 (31.92/12.93)	PPSFAPSTGFSPA.......PSL
  276-  298 (24.44/ 8.41)	PNTTSGGTPFSTQdsiassmPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.42|      17|      25|     432|     451|       8
---------------------------------------------------------------------------
  344-  358 (22.48/ 7.92)	..PQVTNQMPPQ...SQYDP
  393-  408 (30.43/13.47)	QQPNVNMPAQP....GQPNP
  432-  451 (28.51/18.69)	QTPKVNRQLQCHlsiGQTDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30012 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HGFQLEERAHSPAGDHVNIEKPAENKNPSSPAPPSFAPSTGFSPAPSLSEDSTEFKKPNTTSGGTPFSTQDSIASSMPSLPSPQQPQMSQPSPSQGISMQHSPAMPPMQQNPPQQQPQQQPMVSQPQVTNQMPPQSQYDPMKMQNMMPNDMQNRSTAMATNPINQPVFSQPTMDQQPNVNMPAQPGQPNPMKDRKIIW
2) KIRQQQQQQRPDQQPQMPQQTGFPGPQQTMPNQPVQNPQGAQFGVQQMPQVSMQNPMMTQQQANMQQQGQRQPQMIITQGRGGQILHQGHQQVMGGGQVLQGNMPQMAQQGPSSAPQGGNMFDDLNMEFL
219
561
416
690










Molecular Recognition Features






MoRF SequenceStartStop




1) RKIIWQGILE
412
421