<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30007

Description Delta-like protein
SequenceMRTKYNPVQMQVREPKERRNSFLPSMLDNFALLSGQLNTLGKLLRNEKVPPLRNSILLPIALSGDRDPELEKVTERRVIAFNADVVPHYLRTKPEPEVEERLQPVLNRASSLTPEAAQKQINAMNKMTSNIVDIIKSHQETMEKEANQKSSLSQTSSQADTNTLLSAVLTGKGFKSSGMRRTDMAQQQSNMQAQQQAAQQKQQGIQYSSLPKKLKCCGLILANMKWNTEKQCVTVIKEEKQLEHTLESLIQRVQDIKNSIANLLVKLENEYNILQWPSMLDNFALLSGQLNTLGKLLRNEKVPPLRNSILLPIALSGDRDPELEKVTERRVIAFNADVVPHYLRTKPEPEVEERLQPVLNRASSLTPEAAQKQINAMNKMTSNIVDIIKSHQETMEKEANQKSSLSQTSSQADTNTLLSAVLTGKGFKSSGMRRTDMAQQQSNMQAQQQAAQQKQQDDASDHEWELVKKGYSTTRHEMISALEDRLQRIEAKLDNILEQRTIGIQLHRAYDYPVAPHKIALRKAHRKLLQDFHLESEIDKLIQNDVINRETLDEIKSHKSRTNQLRIFLLKLGSYDAQKFNAFLEVLKESHGHLVEELEQCLRNAKEEDVNLFEDDKIEVTCVRCQISRRVQPEEVIDELFSRGIIGATALRKYIDPQSEFKGSKVWKYVFENLKLLQRNKINVAEIMQDILEKNYIDIAESIRCQGPTSWDCTCELHEDLSLRRLHSISNASSEITRKCASCSTATEPYNEAHAQHRQIERPFPTPTDNGASLSHQRKTPDIVITAEDDYGIKMSGAYFDYDKNEIPAAKTTPSLTVEHDKEQLLKPPNHLHKILATHQADTPTPDVTFKNPCYDDDDNASPPEQAGKQHKKVPTKKDIWQQFFSNSHGSSVASSESGKMDAMRMALEFLILLCIVSRISTQESPRATLFITLKEYNNTNSELYNGQCCDGPPSRKCSSDRCDYDINICVTTNGNGSWCHSTQLDVDQPPELVFNENGQNVLVISEWKGSARIDINISDTDGPNTQQLVDSFTFFYIEKGGKTPTFRELVLNGSRVRPSRLRLSMGIQCQTYYYGDQCSVFCIPSVDCKGHYSCDEKTGTKICDQGWEGEDCTRPTVKEGNCITNPCQNGGTCSVDKFSNTTDGDFFCCCPEGYTGSQCDRDINECRSNPCQYGGTCFNTNGGFICKCHPRFRGMNCETPTTCADNPCGIGSCSQTSNDTFSCQCPPNFSGSFCENEVTTSTVRTTSTTTPSTTTTPTTTSTTTTIPTTTIKVTTRTTPSTTKVTTPTTMTTPMTKSTESPTTPSLTSEARSTTFSVLNTMTPSENSSPSALTPSAGKVSYRCPVNACKHNGKCVNGACQCRAGFSGRLCQREDIECKINSCLNGGYCNDNVGNYTCDCPSGFVGSRCEKPVGNATQSTITPTKSACGFCGNGSCSVLENGTAVCMCNPGYSGKTCTYSRNRCRPYSAALCLKGGECIVNSYRTNTEVCPKDWDGPLCRNESISLLRDLECPRVVCKNDGHCYNGSCSRNVIINCVNKSIDDFGLHSRCYIRIHWCHKREHQSWNHTGQRNNCFY
Length1576
PositionHead
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.06
Grand average of hydropathy-0.620
Instability index42.71
Isoelectric point7.11
Molecular weight176121.66
Publications
PubMed=22992520

Function

Annotated function Putative Notch ligand involved in the mediation of Notch signaling. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
calcium ion binding	GO:0005509	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell communication	GO:0007154	IEA:InterPro
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
regulation of apoptotic process	GO:0042981	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.55|      24|      26|      47|      71|       1
---------------------------------------------------------------------------
   47-   69 (40.83/24.05)	EKVPPLR....NSILLPIALSGDRDPE.
   71-   98 (40.34/23.61)	EKVTERRviafNADVVPHYLRTKPEPEV
  300-  323 (46.16/28.82)	EKVPPLR....NSILLPIALSGDRDPEL
  329-  351 (42.22/26.07)	RRVIAF.....NADVVPHYLRTKPEPEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     530.33|     139|     252|      24|     271|       2
---------------------------------------------------------------------------
   99-  254 (256.07/205.72)	EERLQPVLNRASSLTPEAAQKQINAMNKMTSNIVDIIKSHQETMEKEANQKSSLSQTSSQADTNTLLSAVLTGKGFKSSGMRRTDMAQQQSNMQAQQQAAQQKQQGiQYSslpkklkccglilaNMKWNTEKQCVTVIKEEkqLEHTLESLIQRVQ
  352-  490 (274.26/158.57)	EERLQPVLNRASSLTPEAAQKQINAMNKMTSNIVDIIKSHQETMEKEANQKSSLSQTSSQADTNTLLSAVLTGKGFKSSGMRRTDMAQQQSNMQAQQQAAQQKQQD.DAS..............DHEWELVKKGYSTTRHE..MISALEDRLQRIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     435.95|      33|      36|    1167|    1199|       3
---------------------------------------------------------------------------
  940-  964 (37.90/16.23)	...TN..S....ELY..NGQC....C....D........GPPSRKC......SSDRCD
 1083- 1114 (43.81/20.09)	CiPSV..D....CKG..HYSC....D.EK.T........GTKICD....QGWEGEDCT
 1123- 1161 (53.80/26.60)	C.ITN..P....CQN..GGTCsvdkFsNTtD........GDFFCCCP..EGYTGSQCD
 1167- 1199 (69.63/36.92)	C.RSN..P....CQY..GGTC....F.NT.N........GGFICKCH..PRFRGMNCE
 1204- 1236 (58.51/29.67)	C.ADN..P....CGI..GS.C....S.QTsN........DTFSCQCP..PNFSGSFCE
 1344- 1371 (48.24/22.97)	C.PVN..A....CKH..NGKC....V.N...........GA..CQCR..AGFSGRLC.
 1378- 1410 (61.22/31.44)	C.KIN..S....CLN..GGYC....N.DN.V........GNYTCDCP..SGFVGSRCE
 1417- 1458 (37.06/15.68)	T.QSTitPtksaCGFcgNGSC...sV.LE.N........GTAVCMCN..PGYSGKTCT
 1464- 1513 (25.77/ 8.32)	C.RPY..S.aalCLK..GGECivnsY.RT.NtevcpkdwDGPLCRNEsiSLLRDLECP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.48|      23|     250|      24|      46|       4
---------------------------------------------------------------------------
   24-   46 (48.74/28.65)	PSMLDNFALLSGQLNTLGKLLRN
  277-  299 (48.74/28.65)	PSMLDNFALLSGQLNTLGKLLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.42|      24|      24|    1257|    1280|       5
---------------------------------------------------------------------------
 1258- 1283 (39.54/23.17)	PTTTSTTTTIPTTTIKVT.TRTTP.......stT
 1284- 1305 (29.94/15.56)	KVTTPTTMTTPMT..KSTeSPTTP..........
 1306- 1334 (17.94/ 6.05)	....SLTSEARSTTFSVL.NTMTPsensspsalT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      16|      18|     588|     603|       6
---------------------------------------------------------------------------
  588-  603 (29.16/20.79)	KESHGHLVEE..LE.QCLR
  606-  624 (19.22/10.88)	KEEDVNLFEDdkIEvTCVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.01|      12|      18|     751|     763|       7
---------------------------------------------------------------------------
  751-  763 (18.24/16.79)	NEAHAQHrQIERP
  770-  781 (21.77/14.01)	NGASLSH.QRKTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30007 with Med8 domain of Kingdom Metazoa
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