<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30006

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMGKIDNSYLLDLIILGILMQHTPQDLKEKLLETLDDDNNVIDMDGVLAVITILETYPITRDVLEQTRIGKYVNELRKKTDNEQLAKRAKKLVRNWQKLINPEVNGDHGGVAPSHPSVAALSGNGSKPCSPALSQKSLSPVVSQNVVRSSLSKQYPGYKPNTPTQNFNQSVKPSTPKLPQPPRSKPNTPNMPQYLKSGLSPSFSTSDLKGYSTPKASKFPKLNSVHSSPDLSSTVISSQTDRLSNNGSPSNDVELKGRLSRNVSHESLSSLSGSVKDIPQHSHSTRENGRSLSSYSGSVHDDQSLNSKTNVANKKRTRNENQNASSKSESMSYKTVANGSAAPSPVMFSDKSMLNSSRISPSSSTSFSGGGKQQTLPSRRNANLAVSTDTQKPLDKAIKTPKVKTTLQIIADLRAKSGQSIGNQVIHQIETNQIQKESDVLPSVLPPGARPKRRRKQEDLQMSSTPLRPPSSLSQTKRELVENYLESSITPSSAVDMSPFKYELSQSESLGKEESSIDITDSSEVDTSFRPSEVQSKEHYDLRDSINTDTVKKEAPQKVLTLEEIYSQLRPIDYSSVDYDSMETEEEECEVPKCEEEVSENVLERLHNSEWSEVNGLYDINGAWKDWTQTVTVASHNDEPLYILPYVLTDD
Length650
PositionUnknown
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.04
Grand average of hydropathy-0.776
Instability index57.47
Isoelectric point6.36
Molecular weight71730.95
Publications
PubMed=22992520

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP30006
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.57|      21|      23|     146|     168|       1
---------------------------------------------------------------------------
  146-  168 (37.39/22.77)	VRSSLSK..QYPGYKPNTPtqNFNQ
  170-  192 (39.18/18.42)	VKPSTPKlpQPPRSKPNTP..NMPQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.09|      22|      22|     266|     287|       2
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  238-  262 (23.69/ 8.95)	QTDRLSnngSPSNDVELKGRLSRNV
  266-  287 (36.74/17.87)	SLSSLS...GSVKDIPQHSHSTREN
  290-  309 (33.66/15.77)	SLSSYS...GSVHD..DQSLNSKTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.39|      19|      22|     506|     526|       3
---------------------------------------------------------------------------
  506-  526 (29.10/22.41)	SESLGKEESsiDITDSSEVDT
  531-  549 (32.29/18.29)	SEVQSKEHY..DLRDSINTDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.92|      22|     128|     199|     236|       4
---------------------------------------------------------------------------
  199-  220 (37.46/ 7.71)	SPSFSTSDLKGYSTPKASKFPK
  380-  401 (32.47/20.08)	NANLAVSTDTQKPLDKAIKTPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.39|      15|     129|     221|     236|       5
---------------------------------------------------------------------------
  221-  236 (23.07/15.66)	LNSVHSSPDlSSTVIS
  353-  367 (27.32/14.30)	LNSSRISPS.SSTSFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.83|      42|     212|      92|     137|       7
---------------------------------------------------------------------------
   92-  137 (72.06/51.07)	VRNWQKLINPEVNGDHGGVAPSHPSVAalsgNGSKPCSPAL.SQKSL
  310-  352 (67.77/39.41)	VANKKRTRNENQNASSKSESMSYKTVA....NGSAAPSPVMfSDKSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.20|      18|      22|     459|     479|       8
---------------------------------------------------------------------------
  459-  479 (27.22/23.84)	LQMSSTPlrpPSS..LSQTKREL
  484-  503 (27.97/15.09)	LESSITP...SSAvdMSPFKYEL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.16|      18|      37|     562|     579|       9
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  562-  579 (32.29/21.71)	EEIYSQLRPIDYSSVD..YD
  599-  618 (27.88/17.71)	ENVLERLHNSEWSEVNglYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30006 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVNGDHGGVAPSHPSVAALSGNGSKPCSPALSQKSLSPVVSQNV
2) SIGNQVIHQIETNQIQKESDVLPSVLPPGARPKRRRKQEDLQMSSTPLRPPSSLSQTKRELVENYLESS
3) SSLSKQYPGYKPNTPTQNFNQSVKPSTPKLPQPPRSKPNTPNMPQYLKSGLSPSFSTSDLKGYSTPKASKFPKLNSVHSSPDLSSTVISSQTDRLSNNGSPSNDVELKGRLSRNVSHESLSSLSGSVKDIPQHSHSTRENGRSLSSYSGSVHDDQSLNSKTNVANKKRTRNENQNASSKSESMSYKTVANGSAAPSPVMFSDKSMLNSSRISPSSSTSFSGGGKQQTLPSRRNANLAVSTDTQKPLDKAIKTPKV
4) VDMSPFKYELSQSESLGKEESSIDITDSSEVDTSFRPSEVQSKEHYDLRDSINTDTVKKE
102
419
148
494
145
487
402
553










Molecular Recognition Features






MoRF SequenceStartStop




1) LYILPYVLTD
640
649