<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30004

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMSAFPSQENRPLKKPRLGPPDVYPQDTKQKEDELTATSVKHGFNNSPPIGWDEYGSARRENISQEKFGKDFISVLNKKTEINTLQDTTKKKQMPTKDIFWPAAKNQGAMRAWFKDLAGNKPLSSLGRKVPTFNKKEEVFSTLCEFAVPMTKAAWFIKMFAAYNVAVQEKMKQRRHLVDQSMEWCQAITKYMRDQVQKIQEPHSGPGSTAGFLTVSQPDPNQALKQWHYTCKLARHMYDEGLLDRHEFLSWLIDLIEKMKQNEDTVFKLLMAQILLYMEEITRSVILSRRLAHFSSKKIAQLCNEADCMPPRTESPMLTNGSTGMTSSQIITQNPLSTVFAQYNNCPQHRGIVLSLCATLQIITLLCPSSLVWNSLGDEKSSSFLCGSPLDLLPCAPSSLPMPQGPQNMQIRAQIRMAENQVRQRGRAVELRWSSDKCQQSTKGNTITRVLEVLDTLDRHNFDKEDISNSLDTLYHKIFTATQTKDSTEPFISDEPIIHLLIDWSVSTRRSGIYRAVVVAKLLEKRQFELKNEDFDSSMECDGGLGDDVLVSYETPLFQGVLMSYLDDKAPKFSETPAIDDKESVGSDSLVPSGTPYFQAILMSYLDEQAPSLDDNPNDIDRQAFANLIQLFSELIRHDVFSHDAYMCFLISRGDLMSSPLVMSATTDCIDLSSIKSQSESVKHETHDDFKVDIMDMRDMSDIGSLFGTGKDEQRTSPEEPASVKSVMSEKETHHPMSNMLNMEQQPKGPSRHMLYAQHFPIPYEDSVHECNQRTVVLYGVGKARDDAKHVVKKISKEVLKMFSKKNCVDIISGELGRVKKRKEKDASDSLSNVSMNFESVFEGIFNKFQKLSFHDQHFVTAQCRNLVLDEIKNFTTCNSFYLPLVENVSYLFDLMEYSLNIYGLLDFSVQLLKELSNVEEALTDQKSSLVGNYTTSLCLCIVGVFRKYHAYLLVSPELTVVAFEGLISVVRKICNPSDCSSSERCILAYLYDAYTSCNYLKDKFCDMFSNPYRKMKMTLYATITPSASNKLWDPCFMVDFMQQTNIKIPLDDGVINDLRENPAHRYSFVCNAMLHICNTQDTDRLNEISILCAELTARCNALSSEWLGVLQALCFSCANSCGFIDILTQIDASYFIHIYNVSDMSIHDSLAVFTAILIARHCFSLQDLVVHVVLPSLLSARPTASGDQDAENGARLTCHILLRLFKTSDMTLTSPGLRPGTKGQCNIKRSCDKHLLAAAHDSITVGPVLAVLKAMLVLSDLCSDEMRTKSGSSSKKEDKEDIFHSLLSSIDDEEDMHMIMGPSKRKHGMESAGLSDFARHALKEMCKQDWVQEKFLKDPEGVQSSDLLLDNMLSNKQAQQLLQMICYPNGVPNQVDGSEPEVKQIIQRVLQNLDMWGLRVSLLELQLLFKQATTQADTNVLLDNIARGTIDLFHRQTETTNRHLDLDSSQQKPDPDAIWLVGPLISKLPSQVQGRVLKLSGHVLESGNNFQSKGRDKERSQRSKSLLSHQPFLCLILTCLKGQDEQREVLLNSLLSQMERFINNCKEALVSPEVTLSTLPLSVQKSKIHTECTLIGCQKV
Length1580
PositionKinase
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.07
Grand average of hydropathy-0.315
Instability index46.86
Isoelectric point6.00
Molecular weight178240.11
Publications
PubMed=22992520

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30004
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.33|      17|      28|    1264|    1280|       1
---------------------------------------------------------------------------
 1264- 1280 (27.89/17.10)	DEMRTKSGSSSKKEDKE
 1294- 1310 (32.44/21.12)	EDMHMIMGPSKRKHGME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.69|      48|     211|     192|     271|       2
---------------------------------------------------------------------------
  130-  177 (83.53/81.32)	PTFNKKEEVFSTLCEFAVPMTKAAWFIKM.FAAYNVAVQEKMKQRRHLV
  217-  265 (83.15/55.48)	PDPNQALKQWHYTCKLARHMYDEGLLDRHeFLSWLIDLIEKMKQNEDTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.59|      36|      37|     541|     576|       3
---------------------------------------------------------------------------
  541-  576 (68.53/43.64)	DG..GLGDDVLVSYETPLFQGVLMSYLDDKAPKFSETP
  579-  616 (64.06/40.29)	DDkeSVGSDSLVPSGTPYFQAILMSYLDEQAPSLDDNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.30|      24|     205|     832|     866|       4
---------------------------------------------------------------------------
  832-  856 (39.64/44.04)	NVSMNFEsVFEGIFNKFQKLSFHDQ
  887-  910 (42.66/19.67)	NVSYLFD.LMEYSLNIYGLLDFSVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     307.11|      97|     235|     433|     540|       7
---------------------------------------------------------------------------
  433-  540 (141.33/123.47)	SSDKCQ.QSTKGNTITRvLEVlDTLDRHnfDKEDISNSLDTLYHKIFTATQTKDSTEPFISDEPIIHLLIDW.SVSTRRSGIYRavvvaKLLEKRQFELKNEdfDSSMEC
  672-  770 (165.78/109.80)	SSIKSQsESVKHETHDD.FKV.DIMDMR..DMSDIGSLFGTGKDEQRTSPEEPASVKSVMSEKETHHPMSNMlNMEQQPKGPSR.....HMLYAQHFPIPYE..DSVHEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.20|      24|      27|    1315|    1341|       8
---------------------------------------------------------------------------
 1315- 1341 (38.84/39.67)	SDFarhALKEMCKQDWVQE..KFLKDPEG
 1345- 1370 (38.36/28.38)	SDL...LLDNMLSNKQAQQllQMICYPNG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.25|      25|      27|    1168|    1193|       9
---------------------------------------------------------------------------
 1168- 1193 (36.17/25.29)	LVVHVVLpSLLSARP...TASGDQDAENG
 1196- 1223 (39.09/22.19)	LTCHILL.RLFKTSDmtlTSPGLRPGTKG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.57|      16|      28|     998|    1018|      12
---------------------------------------------------------------------------
  998- 1018 (18.56/23.44)	NYLKDKfCdmFSNPYrkMKMT
 1029- 1044 (34.02/17.36)	NKLWDP.C..FMVDF..MQQT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.57|      16|      21|    1077|    1092|      14
---------------------------------------------------------------------------
 1077- 1092 (29.16/21.35)	CNTQDTDRLNEISILC
 1099- 1114 (29.41/21.60)	CNALSSEWLGVLQALC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30004 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSAFPSQENRPLKKPRLGPPDVYPQDTKQKEDELTATSVKHG
2) SLFGTGKDEQRTSPEEPASVKSVMSEKETHHPMSNMLNMEQQPKGPSRHMLY
1
704
42
755










Molecular Recognition Features






MoRF SequenceStartStop




1) NRPLKKPRLGPPDVYPQD
9
26