<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29999

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMCPIPGNLMLRGSQHYSKTALEEHKEKIDMYVEPSSAIKHGIKKLEEKNIIIITGDAGIGKTRFALELMSRIQNKHQNLTALVLTDSSQWDKLDFKKVYILLIDDTFGKSKLHECAFQSWCSVFDRMDKRLQTGQVMVIFAQRNCIWHLIKDRLSDYPLFRAIVLENAQIDLSGEFSLTRDEKARILANFCRRLNVKYCLTLYEEETLSIFSTDGLLRLSHETIRTLLNMDTSCGFPFLCEQSFSDCNLSNKSILNIFQIHSNLTYMKELVDDLLCQQKNIHYAVLVFLFLEDKSCNVDAILKAKKKIADLGIVNSSEIIPAKIKGCLKDMMNACIDVSDDGGFKLRHKRIYSAVLLSFGENFPRKFLEFISKTVLFYNVRSEGYEGGKQETFVRLDVDMTLPFAKKLIDVYGSNKEEAFSEVYKHPSFLDKRLVDCFLGITENDEAFTAQLHSFIYGACEYGNDFLAKIVLDRLTVCPKTLTEMPPIIDPHIGMSGGAPGGGTIPLATLIDYIVQRTYHELSVLSELLPRKTDMERKVEIVQFASRTRQLFIRLLALVKWASSATKVDKCSEICNFLEQQSMWFVETADMLAKMARETLVNARLPTFSLPCAIDVLTLGSYPRLPSCIRDKIVPPDAITPAEKRQTLQRLTQVIQYRLVATDLPPQMRKLKVENGRVKFNVEHEFEATLTLMGDSPKIPWRLLDITLLVEDPETGDGKSLVHSLQINYIHQLVQSRLMDNERPLHDLYRLLHTFCLSLQLEVLYSQTQRLIKDRMGDSICVEKYDIGKCLSLSYWRDPNRRDRSQDALLFRLSLHVAEDDDGRPLQISHFPSMSPEESSKVGQAIKSNHLSMERLLIQTIEVRGLAKLKDLAKDLQRFTEGACEIRDLPIALHVPLLEPSMDSEKLRVMVDCQRGNLLASVPTSKDLQEVDELEDALNGDRKNLDRLVRNLRLRLCVMRCEKSSQYLPTICQKHLPFINLTNHPLEKLSKSRLYIRVPKQSAFYLVVELVEGDTTVDYRYHLLDTTQCTSDGSEIDISEDPCPKLYLRAGRLIPLDVNSFIHGPYTKLYDEQEQSNIESKRRKRKIMLGELREPAVKKTKGQPYFTPELAYILASCEERIPLVNLGLEFEKNGVVHNGVQADCEGTCFCLSILSMPDVDGLSEEMCTKINNLLLSLKVRILSKPMRNWIVEFLFSKPVLESSNKKEQGPVQRVHIMMELNIDNLKKVVKDILDEWAGICHLYSIVHEFAQMYSDVRTELKNTVEIYSYDYRKLSMIYGPSQTSLINIQWKGDAKQFNVSLGTVGNSSTVNPHTVLLSQYQRELNHTRSLAQICQVNPHSHSLTQICQVNPHSHSLTQICQVLHETWAPMMSINKLNMSLVQAAATNTKQPMQSFTVIPQSTTHVRIAFRNISCIDVHFRSNKIVSVRDGAYSLFDNSKAVDGFSPTSMFKHFLNKYVDDAITGRHTHRMSTTEDDNPPSPMDSIDIFSLSSQPPSTGSPASRQRGETGLRFPMTPPSNPHTPASPSAARMSGVTPSPSTALIGTPSPGTLLNVGSPGNPQLHVPSPGSSAFVPAPSPQSLGIHMPSPASGFMGPQGLDVGSPFTNASLAMPSPVQRNWPNSPSVAGPSPASRHTAHSPGNPALHSPQTQAKDGDHSKAAMISHTTRMLPQRAWAASIPTLLSHDAFDTLLTPNRPQGLPYTVSLSPLERFLGSVYLRRNLPRLIQSESLTPLRSTDPNITSFKVETLQFHVTFSNNLQSLHMNVQPVPEHRDQWSVEVLNIIQQYFDSKVACPPYKVNALRAFCRILDTPIRILKDCVQMMRLELMGPNQSGNMKWSMQWCLTVPPHAAFVAPAGTAAVAKNKQIKMLLMLQFTRANIQPPAGQDPQSIIVPLLYDISANTIQHMEPVRGQPQTPAYMAVSQLLQNFYHPQSAECILFPAVQHIMANLNL
Length1951
PositionTail
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.07
Grand average of hydropathy-0.234
Instability index48.33
Isoelectric point8.00
Molecular weight219926.13
Publications
PubMed=22992520

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29999
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     220.38|      36|      36|    1560|    1595|       1
---------------------------------------------------------------------------
 1480- 1513 (49.40/22.83)	SPMDSidIFSLS.SQP.PS........TG....SPASRQ..RGE..TGLRFP
 1515- 1538 (26.65/ 8.99)	TPPSN..PHTPAsPSA.AR........MSGVTPSP.................
 1539- 1565 (41.07/17.76)	...ST..ALIGT.PSP.GT........L.LNVGSP.......GN..PQLHVP
 1566- 1601 (69.53/35.08)	SPGSS..AFVPA.PSP.QS........LGIHMPSPASGF..MGP..QGLDVG
 1602- 1645 (33.73/13.30)	SPFTN..ASLAM.PSPvQRnwpnspsvAG...PSPASRHtaHSPgnPALH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.40|      36|      36|    1310|    1345|       2
---------------------------------------------------------------------------
 1310- 1345 (70.16/39.30)	VNPHTVLLSQYQRELNHT...RSLAQICQV...........NPHSHSLTQ
 1349- 1382 (35.48/16.47)	VNP.............HS...HSLTQICQVlhetwapmmsiNKLNMSLVQ
 1700- 1731 (35.76/16.66)	..PYTVSLSPLERFLGSVylrRNLPRLIQ...............SESLT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.32|      16|     182|     467|     487|       4
---------------------------------------------------------------------------
  430-  446 (24.68/ 8.85)	LDkRLVDCFLGITENDE
  472-  487 (30.65/12.24)	LD.RLTVCPKTLTEMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.98|      17|     100|     348|     366|       5
---------------------------------------------------------------------------
  348-  366 (27.44/20.87)	HKRIYSAVllSFGENFPRK
  453-  469 (33.54/19.49)	HSFIYGAC..EYGNDFLAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.67|      60|     100|     714|     781|       6
---------------------------------------------------------------------------
  714-  781 (89.62/85.71)	ETGDGKslvhSLQINYIHQLV...QSRLMDNERPLH.DLYRLLhtfCLSLQLEVLySQTQRLIKD..RMGDSIC
  819-  884 (83.05/56.37)	EDDDGR....PLQISHFPSMSpeeSSKVGQAIKSNHlSMERLL...IQTIEVRGL.AKLKDLAKDlqRFTEGAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.59|      57|     100|     504|     566|       9
---------------------------------------------------------------------------
  504-  566 (80.65/62.40)	TIPLATLIDYIVQRTYHEL..SVLSELLPrkTDMerkvEIVQFASRTRQLFIRLLALVKWASSAT
  573-  599 (26.17/ 9.05)	......................................EICNFLEQQSMWFVETADMLAKMARET
  607-  662 (83.77/50.44)	TFSLPCAIDVLTLGSYPRLpsCIRDKIVP..PDA......ITPAEK.RQTLQRLTQVIQYRLVAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.76|      17|      32|    1214|    1230|      12
---------------------------------------------------------------------------
 1214- 1230 (28.50/19.90)	VHIMMELNID...NLKKVVK
 1246- 1265 (24.27/15.75)	VHEFAQMYSDvrtELKNTVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29999 with Med14 domain of Kingdom Metazoa
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