<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29990

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMVFVAASGDQDAENGARLTCHILLRLFKTSDMTLTSPGLRPGSKGQCNIKRSCDKHLLAAAHDSITVGPVLAVLKAMLAQQLLQMICYPNGVPNQVDGSEPEVKQIIQRVLQNLDMWGLRVSLLELQLLFKQATTQADTNVLLDNIARGTIDLFHRQTETTNRHLDLDSSQQKPDPDAIWLVGPLISKLPSQVQGRVLKLSGHVLESGNNFQSKGRDKERSQRSKSLLSHQPFLCLILTCLKGQDEQREVLLNSLLSQMERFINNCKEALVHQYQQCSLFADDPPSFLLFCSGKGLEQIKYAKKKMLKKIHGQMLNRYKLGDKQSDSIDKIRQLLPIPKRFFEVMSCEAHGTQMDSKGNKYDGFGKKEGFQVAKKEKISPWEVIEGYKNPPPLSWHLFGAVKQEKKPLKYEDQHRILLFHTHSLRQPLAHFLDPPSLPPEDLEPVPEKHEEKPKEANENQHPDMSKKRKPPKKTKRSNSGSGQGGYNIQPTVRQYPTSANWYPTQTQQHPQFYGNQPMSAGPRFEAPAYGMPGLTPSKMALQQMIRTRHPGNMHQWSGSNQNSMQALQMLQKQHSHRMVRQQIRQSFQNHNRGMTTDGGQGMFSGGMHSMNQSQGECGGGINGIIMRYNNGDTFISEILDRLRKLCIL
Length648
PositionKinase
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.06
Grand average of hydropathy-0.654
Instability index49.18
Isoelectric point9.42
Molecular weight73214.17
Publications
PubMed=22992520

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.84|      24|      26|     539|     562|       1
---------------------------------------------------------------------------
  539-  562 (47.18/28.96)	MALQQMIRTRHPGNM..HQWSGSNQN
  564-  589 (39.66/23.19)	MQALQMLQKQHSHRMvrQQIRQSFQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.72|      23|      26|     215|     240|       2
---------------------------------------------------------------------------
  215-  240 (36.95/31.09)	GRDKERSQRSKSLLSH.QPFlclILTC
  243-  266 (36.77/21.97)	GQDEQREVLLNSLLSQmERF...INNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.23|      23|      26|     468|     490|       3
---------------------------------------------------------------------------
  468-  490 (41.61/24.07)	RKPPKKTKRSNSGSGQGG..YNIQP
  493-  517 (41.62/24.08)	RQYPTSANWYPTQTQQHPqfYGNQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.88|      26|      45|     389|     414|       4
---------------------------------------------------------------------------
  389-  414 (49.84/34.18)	NPPPLSWHLFGAV..KQEKKPLK.YEDQH
  433-  461 (39.03/25.03)	DPPSLPPEDLEPVpeKHEEKPKEaNENQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.38|      45|     309|     289|     334|       5
---------------------------------------------------------------------------
  289-  334 (73.17/38.55)	LFCSGKGLEQIKYAKKKMLKKIHGqMLNRYK.LGDK.QSDSIDKIRQL
  345-  374 (40.42/16.76)	MSCEAHG........TQMDSK..G...NKYDgFGKK.EGFQVAK....
  602-  645 (70.79/33.74)	MF.SG.GMHSMNQSQGECGGGING.IIMRYN.NGDTfISEILDRLRKL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29990 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LAHFLDPPSLPPEDLEPVPEKHEEKPKEANENQHPDMSKKRKPPKKTKRSNSGSGQGGYNIQPTVRQYPTSANWYPTQTQQHPQFYGNQPMSAGPRFEAPAYGMPGLTPSKMALQQMIRTRHPGNMHQWSGSNQNSMQALQMLQKQHSHRMVRQQIRQSFQNHNRGMTTDGGQGMFSGGMHSMNQSQGE
428
616










Molecular Recognition Features






MoRF SequenceStartStop




NANANA