<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29987
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MQQQRPQTSIGNISQASQMAFGQQIFRNFIVLLFYGIQMQAGPNASSQQAVPSPKPPSISSMMMSPSPQGMVANPRGNSPRVLNTPGGPNSPSPNTPRSHEEQAYLDKLKQLQKYIEPLKRMINRLTTGKDEESKKDISKMENLLKILTDPSKRLPMATLLKCEQVLDSLEMAKPPGVGSVPSATTTITSTPMHMCQPLLDAVATNMKSPMFNHALQQTFGPAMTALFGAPIRAPSPPPKKRKREEVEEDEDIPHILQGEIARLGSRFRVNLDPTQHSKSKDVHLVCKIDDKNLPCVPPISVKVPELYPQVSPQCDTKTQDYESSPFLSSIQESLSRLLLQMPSKYTFTELMDKWEMSIRRACAAPS |
Length | 367 |
Position | Tail |
Organism | Crassostrea gigas (Pacific oyster) (Crassostrea angulata) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia>
Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.516 |
Instability index | 71.54 |
Isoelectric point | 9.12 |
Molecular weight | 40703.56 |
Publications | PubMed=22992520
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29987
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 137.17| 44| 127| 37| 89| 1
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38- 69 (44.91/26.77) ................QMQAgP..NASSQQAVPSPKPPSISSMMM.....SPSPQ
73- 95 (28.00/13.07) ANPRGNSPRVLNT................................pggpnSPSPN
190- 237 (64.26/30.69) STPMHMCQPLLDAvatNMKS.PmfNHALQQTFGPAMTALFGAPIR.....APSP.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 86.12| 27| 30| 96| 122| 2
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96- 122 (46.70/31.42) TPRSHEEQAYLDKLKQLQKYI.EPLKRM
128- 155 (39.42/25.47) TGKDEESKKDISKMENLLKILtDPSKRL
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