<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29983

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMELSTIALPYGKIYHLFLSFCQEDEERIDDLCNEIVEELNTSRYRTRYILYSASFWGRLWCFLVLGAPALTVLPLLIVLIKEGEITEQTLAGVCSTLVVVPIVAVSIFLCCCFGKNMIKGRKLLEKITWKHLSTNYQTLMVLPLIRSTEEKQNGGKMNEPIRRPEQGSPRSSPRGSRSPAYPRTDSSGTLKTTISLGRVPSVIHSGPFYLVKDIGPAHPSHSGITGSTNLMIHYGLQNSYSKFCKKEGKEELSAFLPNLPGYIDTPGMQDNSSLRSLIENPPKTSKELVPLSGPALQGFRLHPGPLPEQYRFMSHMPRKKHKLKKKEREREKPGNMQDAQDNSPEVKTKKVKTEEKKKKKKKNKKKAKEKDDGSLFISIPPT
Length382
PositionHead
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.07
Grand average of hydropathy-0.511
Instability index47.35
Isoelectric point9.55
Molecular weight43041.54
Publications
PubMed=22992520

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29983
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.86|      13|      35|     318|     332|       1
---------------------------------------------------------------------------
  318-  330 (22.07/ 8.52)	RKKHKLKKKERER
  358-  370 (20.80/ 7.43)	KKKKKNKKKAKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.00|      17|      68|      60|      76|       2
---------------------------------------------------------------------------
   60-   76 (31.70/20.79)	WCFLVLGAPALTVLPLL
  129-  145 (32.30/21.30)	WKHLSTNYQTLMVLPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.61|      22|      35|     246|     267|       3
---------------------------------------------------------------------------
  246-  267 (39.97/25.30)	KEGKEELSAFLPNLPGYIDTPG
  283-  304 (39.64/25.03)	KTSKELVPLSGPALQGFRLHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.92|      19|      35|     179|     197|       4
---------------------------------------------------------------------------
  179-  197 (33.45/20.53)	PAYP.RTDSSGTLKTTISLG
  216-  235 (32.47/19.75)	PAHPsHSGITGSTNLMIHYG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29983 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPNLPGYIDTPGMQDNSSLRSLIENPPKTSKELVPLSGPALQGFRLHPGPLPEQYRFMSHMPRKKHKLKKKEREREKPGNMQDAQDNSPEVKTKKVKTEEKKKKKKKNKKKAKEKDDGSLFISIPPT
2) QNGGKMNEPIRRPEQGSPRSSPRGSRSPAYPRTDSS
255
152
382
187










Molecular Recognition Features






MoRF SequenceStartStop




1) NMQDAQDNSPEVKTKKVKTEEKKKKKKKNKKKAKEKDDGSLFISIPPT
335
382