<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29978

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAASLRISLNNMENGDISSGVLSSKERDLKRQMEKLHRCYMKKKEWKDSMRVVQQSMSREKKMLMETDKEPGSLRSCLDRLQSCIKVVSQQTLLERLETTSRLVDLSFSPPTGTENSAIISSEMFRIEIIFDPGGLVKDVRISHQGEPTSCDEITEVLRQGNFDEFIVHLKGLQSIYNISGDRKQKSKAYLALQALETDLNSLAQLQSSIKGCPMKLVYFVSPYDLLNKRTRSPHPMTVEAITEHGLGQSVTVCIEPHSHRRLQTIPLMSVVPQDGKSLPSFQALSQVNSTSLPACFTLMLARPIPVAMSVIHAIQEVTDIDVITEGEPESLLKLILAQSSGGKLSPGSEFFVTLPDQQHAYYLRDIGESSLDQTAKMVSRIPFTHPTNVANILNLLRQQLLFNTVISSCIRPYAKQDLMSSVVFELVCTSLQQFTIMFEHPLQDTMVTAEVDLSDITGVKFKVSIGEDGEDLLSDDAASKIFQRCWSVPVTLRSIIHKVSEQLRKEPSPEPVAMEIEQPPFVMPQEVTFATPYLPAMDSKSISSPGNMVLPNAKIPQGYGGIPPNTTQGAMLPPPIVEDSKKLDDDVPSSNPLLVTLLDQDSPDPDPPSVPESPMLSRLLEDSPSNNNTNSSLNNNNNVANLASSVPAPLKPGRGRPPKRKSVTDPPKGKSPKHRLTDNEYQSQSLSFESLTSSFDSDFQNASMDSQRFPHFSLSSPIDLTDDSVNPLRGLENTLDSIQSKQSMHHSSDPLANLTSELDSIQDVSIFSQTNSVPKNMARSTSLEGILNRSGEVSRTKDLHKPHHLQDSMPTNQARKTLVRQNSVGKVAQYQHQISIDSNDSFKAGSNLSFSRSTSFTHGNTSDSDTSLYSTRSFDLSDSFNNLSPVSNSSISRHDIGGDLTTEFKPELKLGHKDLRSLLMSSPNENSLLQSEKLKIKNTKGKMRMKLSGIKNSDLLGINRKKSSAEAYDFNSDEEDSNDLSMITASPTGLQLFNKSKTAKHLLNKIGKGDKLKKKEAKSTEPGKRKRDKKEKEHKKKKRLDSNSRATSCEMYSATPVESEDKTSTKLKIIKSVGVSMENSPRSSPSGREKGDGTRKSSINSQKSLKNSHKSLSMTSVNVSKEDSKLMTKTPKIKLKPIAIPPSSAVSNAKTPTPTSSPGSATPTSTTIGRIGAVSILTSGNSKAGGTTPSPGKVSTPTSAKTQPTFGGSKSFPSNKSVASSSTSLKAASAERKLSQSGRLSSGISKSSNGKYSSDRKSGSPSVSGSKSGLNSSKSLNSSSKGQSSNSFSKNSNNPLNSVLSFLNPKDKGLSSLPRIPKISSASSSNNNTKPTVSVTSTSVSTTTSVSTSVAGMSKLTTVNSHSNTKVSVSNNPHQGGVRSSPNTPGTPKNFPANSKNSANLNSKSTLVNSPNIRGSQMGSRSPSVNSANNKSPSSSNGKSPLSHTSNKLGINGRPPSNSNPPKTPVGSNTAHPLKTPTPGSGHNNGSPNINKPIPISTPPPTTTINKSNPQTSSPSSYPPKATPTGDQSPSVSNLSRNSPLLSQGPPGKTPNLVTKVSESPKSILVTTASKVTSPIMVSTDTPPKTTTPGSMVSPTTSCPSSNAKMRPRKSSLSAVIDKLTNAKVPHGVGGETNRQNSLDEGGEQAKAKTENALDGLDKASNGLERQSVSEPKKADSSDKNLPSKDSPSGIDKNKDLKIVDNSRNLFASLLKSASENFTSKHDKDDKENVSKSETGGKPGDSSEDVDSKAKDLSMQSVCKKSPKVIPKVNGETNVTVDNSIRKGEGDVFKVPTPKSVVSVDENDCEDIENMSVRRKARISTTKPVLSPASSGGSPENLIIDCQSPRQHSKNNSLNSPKCIVDLNDENKKLSPVTVVNNRQKTHTPSPKPKHSPNPSPKSVQHSSPAGMLEIDDDLMNEAIMGFTS
Length1926
PositionMiddle
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Ostreida> Ostreoidea> Ostreidae> Crassostrea.
Aromaticity0.03
Grand average of hydropathy-0.672
Instability index55.12
Isoelectric point9.44
Molecular weight207230.35
Publications
PubMed=22992520

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1175.95|     168|     168|    1017|    1184|       1
---------------------------------------------------------------------------
  738-  899 (131.37/43.57)	....SIQSKQSMHHSSD...PLaNLTSELDSI.Q.....DVSIFSQ.TnsvPKnmarsT.S.......L...EGI..L...NR.SGEV..S..RTKDLH..KPH.HLQD.SMPTNQ......ARKTLVRQNS...................................................vgkVAQYQHQISIDSN.DsfKAGS................NLSFSRST.SFTH.....GNTSdsdT.SLYSTRSFDLsdS.FNNlSP..VSN..SSiSRHDIGG
  900- 1094 (181.80/63.71)	DLTTEFKPE..LKLGHKdlrSL.LMSSPN....E.....NSLLQSE.K...LK.....I.KntkgkmrM...KLSG.I...KN.SDLL..G.iNRK.......K.SSAE.AYDFNSDEEDSNDLSMITA..S....PtglqlfnksktakhllnkigkgdklkkkEAKSTEPGKRKRD...KK...EKEHKKKKRLDSN.S..RATS................CEMYSATP.VESE.....DKTS...T.KLKIIKSVGV..S.MEN.SP..RSS..PS.GREKGDG
 1095- 1266 (224.45/80.74)	TRKSSINSQKSLKNSHK...SL.SMTSVNVSK.E.....DSKLMTK.T...PK.....I.K.......L...KPIA.I...PP.SSAV..S..NAKTPT..PTS.SPGS.ATPTSTTIGRIGAVSILTSGNS....K...........................aGGTTPSPGKVSTPtsaKT...QPTFGGSKSFPSNkS..VASS................STSLKAAS...AE.....RKLS...Q.SGRL..SSGI..SkSSN.GK..YSSdrKS.GSPSVSG
 1267- 1454 (155.56/53.23)	S.KSGLNSSKSLNSSSK...GQ.SSNSF..SK.NsnnplNSVLSFL.N...PK.....D.K......gL...SSLPrI...PKiSSAS..SsnNNTKPTvsVTStSVST.TTSVSTSVA...GMSKLTTVNShsntK............................VSVSNNPHQGGVR...SS...PNTPGTPKNFPAN.S..KNSAnlnskstlvnspnirgSQMGSRSPsVNSA.....NN............KSPSS..S.NGK.SP..LSH..TS.NKLGING
 1455- 1555 (118.61/38.47)	RPPSNSNPPKTPVGSNT...A....HPLKTPT.P.....GSGHNNG.S...PN.....I.N...........KPIP.IstpPP.TTTInkS..NPQTSS..PSS.YPPK.ATPTG...DQSPSVSNL.SRNS.........................................................................................................................................PllSQG..PP.GKTPNLV
 1556- 1646 (106.70/33.72)	TKVS..ESPKSI..............................LVTT.A...SK.....V.........T...SPIM.V...............STDTPP..KTT.TPGSmVSPT.............TSCPS....S............................NAK.MRPRK............................................................SSlsaviDKL....T.NAKVPHGVG...G.ETN.RQ..NSL..DE.G...GEQ
 1647- 1772 (123.68/40.50)	AKAKTENALDGLDKASN...GL.ERQSVSEPK.K.adssDKNLPSKdS...PS....gIdK.......N...KDLK.I.........V..D..NSRN.L..FAS.LLKS.ASENFTS..........................................................KHD...KD...DKENVSKSETGGK...............................P.GDSS.....EDVD...S.KAK.....DL..S.MQS.VC..KKS..PK.VIPKVNG
 1777- 1908 (133.78/44.53)	TVDNSI..RKGEGDVFKvptPK.SVVSVDENDcE.....DIENMSV.R...RK.....A.R.......IsttKPVL.S...PA.SSGG..S..PENLII..DCQ.SP...................................................................RQHS...KN...NSLNSPKCIVDLN.D..E..N................KKLSPVTV.VNNR.....QKTH...TpSPKPKHSPNP..S.PKS.VQ..HSS..PA.G......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.20|      36|      42|     564|     604|       2
---------------------------------------------------------------------------
  513-  547 (38.40/12.42)	VAMEIEQPPfvmPQEVTfATPYLPA.M..DSK................SISS..PG...
  564-  593 (32.70/21.51)	............PPNTT.QGAMLPPpIVEDSK................KLDDDVPSsnP
  596-  650 (48.10/24.05)	VTLLDQDSPdpdPPSVP.ESPMLSR.LLEDSPsnnntnsslnnnnnvaNLASSVPA..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.89|      20|     237|     136|     167|       3
---------------------------------------------------------------------------
  110-  130 (29.61/24.33)	PPTGTENSAIISSEMFRiEII
  148-  167 (35.29/11.59)	PTSCDEITEVLRQGNFD.EFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29978 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAYDFNSDEEDSNDLSMITASPTGLQLFNKSKTAKHLLNKIGKGDKLKKKEAKSTEPGKRKRDKKEKEHKKKKRLDSNSRATSCEMYSATPVESEDKTSTKLKIIKSVGVSMENSPRSSPSGREKGDGTRKSSINSQKSLKNSHKSLSMTSVNVSKEDSKLMTKTPKIKLKPIAIPPSSAVSNAKTPTPTSSPGSATPTSTTIGRIGAVSILTSGNSKAGGTTPSPGKVSTPTSAKTQPTFGGSKSFPSNKSVASSSTSLKAASAERKLSQSGRLSSGISKSSNGKYSSDRKSGSPSVSGSKSGLNSSKSLNSSSKGQSSNSFSKNSNNPLNSVLSFLNPKDKGLSSLPRIPKISSASSSNNNTKPTVSVTSTSVSTTTSVSTSVAGMSKLTTVNSHSNTKVSVSNNPHQGGVRSSPNTPGTPKNFPANSKNSANLNSKSTLVNSPNIRGSQMGSRSPSVNSANNKSPSSSNGKSPLSHTSNKLGINGRPPSNSNPPKTPVGSNTAHPLKTPTPGSGHNNGSPNINKPIPISTPPPTTTINKSNPQTSSPSSYPPKATPTGDQSPSVSNLSRNSPLLSQGPPGKTPNLVTKVSESPKSILVTTASKVTSPIMVSTDTPPKTTTPGSMVSPTTSCPSSNAKMRPRKSSLSAVIDKLTNAKVPHGVGGETNRQNSLDEGGEQAKAKTENALDGLDKASNGLERQSVSEPKKADSSDKNLPSKDSPSGIDKNKDLK
2) KSISSPGNMVLPNAKIPQGYGGIPPNTTQGAMLPPPIVEDSKKLDDDVPSSNPLLVTLLDQDSPDPDPPSVPESPMLSRLLEDSPSNNNTNSSLNNNNNVANLASSVPAPLKPGRGRPPKRKSVTDPPKGKSPKHRLTDNEYQSQSLSFES
3) LLKSASENFTSKHDKDDKENVSKSETGGKPGDSSEDVDSKAKDLSMQSVCKKSPKVIPKVNGETNVTVDNSIRKGEGDVFKVPTPKSVVSVDENDCEDIENMSVRRKARISTTKPVLSPASSGGSPENLIIDCQSPRQHSKNNSLNSPKCIVDLNDENKKLSPVTVVNNRQKTHTPSPKPKHSPNPSPKSVQHSSPAGMLEIDDDLMNEAIMGFT
4) MARSTSLEGILNRSGEVSRTKDLHKPHHLQDSMPTNQARKTLVRQNSV
5) NSLLQSEKLKIKNTKGKMRMKLSGIKNSDLL
6) TSSFDSDFQNASMDSQRFPHFSLSSPIDLTDDSVNPLRGLENTLDSIQSKQSMHHSSDPLANLT
967
541
1711
778
927
693
1699
691
1925
825
957
756










Molecular Recognition Features






MoRF SequenceStartStop




1) KHLLNKIGKGDKLKKKEA
2) KRKRDKKEKEHKKKKRL
3) LMTKTPKIKLKPIAI
4) MNEAIMGF
5) SLPRIPKI
1001
1025
1127
1917
1313
1018
1041
1141
1924
1320