<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29975

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSRLSGTSSLNNSGPGGRPNQKIQSSRDELIHNRYRLDEPQGVFPLDNFPISEFNGTASHHQGGHFTIQQHSSAGSGSSGGFGLGSGVSHKYPDFQPWEHSPQEDNLAVNHLQKGFFETPYVANELLSARNIMHQLLRSQSSLEALSSNLLEAIDVRSSNNKIGPSSYKPPPRVTLTDQKRENWLKDLANNDVSLRKLARTIPHGVRNKSLLDQCVLKRIPINRAIWFVRCVGTNELRGLKRKGGANIEFNWIQEWTLQVVEYIEKLSLEYLKYENCANKENNIDMKLWKAKLTYIIRFTANLYMEQLIDKETFKNWISRFFKNCKNFELPLSLTIIKIFWIDILKTDYLIKELTESLLIRYHLINSNKHVLDSKDLNITDQKLNEQIKNKLLKILQNLIIDSFNQSIDNFILPNSWNQLKSIIKSIIIKSNDNNYETSKKFDHISYRNESLMINYSLDSKEQENTLIQILDQNTLIYDFKLIIELIFNESWKNNLKLLIHWSITKFRDGIERIYLIVEIFKNFKQFQKLISHKDIESEVLNIIFNLKNHLNMINFDQLFLLLNELSSSSTTKFFKINIYVRKLISSGLTYLLDNQDEKNLHASILKNLKNGITSQSLLVLKNLDSTFDETFKLQIEKNLEFAKNLINNSIQIEGELDNNSLIFIKSLPMGIKLKLSDYILKNLVDDVNSNTNFSILSRIFDALGDYRCFHNYILKILGGNTLSLDNLESISEFIISFSRLTGLFTNFDRITELFILNYNRISMKYIDLNKFWNLMLGVIKDDKLQIEVKQIINNNKIFKDIDTDFLQKTILESSIEIEFEDFISISNFHNNFQVLIRLIFNGANSNDLIIKRSILTLLKFLKRQNFTEFNKILFIYIKKTYSNANEIFRQEPILDLIVSELVPLNLVVDTFINFQSNIYTTIVKDLLFRDFSEFKNFDYLKFNYLRLQYLQKNQSIVLTLFKNSIEDFTDVLNNNNNNVKNENIQSDSTDILNNFLSDHQHINKSNNSNYKNEFLNFFLQNLIYNQGLVIKIFNIDENDEYRSKFLSILNDALFSESITLSKSTIETEDLSNLIKLISNNINDLNLPVFQLLFKLKMDVVKSNPQLILEFFNSLTENIKNDEGSIGSLFELVDDEMKKKFIHYLENLFLTSKKFPQISIDDTKIPLNLISDNLIKLSKKFEKVELPDELLFALDNSLELLLKIVNKSEFTTDLYDSLGLFLRIIIIHKAFIIDIIVERNSIKETFLNNLVNLLTSKFISQNLPLKNLLYDLLLSFKSNVNEMNISNKSNIVKLPISLINLPAISENSTINHGNQFNSNIHDESIINDLYIYNKSSKTYNELNVKAFDLVEDSNPVENLNDTAINLQLFETSIERKNPA
Length1379
PositionKinase
OrganismWickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.10
Grand average of hydropathy-0.237
Instability index38.13
Isoelectric point6.33
Molecular weight160220.59
Publications
PubMed=23193139

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29975
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1031.77|     178|     179|     959|    1136|       1
---------------------------------------------------------------------------
  279-  423 (121.14/45.12)	..................NKENNIDM.KLWKAKLTYII.R...FTANlymE..QLIDK......ETFKNW.ISR.FFknCKN.....FELPLsltIIK.IF.WID....................ILkTDY.....L...IKE...LTESL.........LIRyhLINSNkhvldSKDLNI....TDQKLN.EQIK..NKLLKILQNL.II.DSFNQSID..NfiLPNSWNQL.....KSI.......
  429-  577 (151.35/58.36)	................IKSNDNNYET.....SKKFDHI.S...YRNE...S..LMINYSlD..SKEQENT.LIQ.IL..DQN..tLIYDFKL...IIElIF.N..E..S.WK.NNL..KLL..I.HW.SIT.....K...FRDGIERIYLIVEIfKNFKQFQK..LISH.......KDIES....EVLNII.FNLKnhLNMINFD.QL.FL..LLNELSS..S........ST.....TKFFKI....
  578-  729 (131.72/49.75)	......NIY........................VRKLISSgltYLLD...N..Q......D..EKNLHAS.ILK.N...LKN...GITSQSL..lVLK....NLDS..TfDEtFK.....L..Q.IE.KNL.....E...FAKNLINNSIQIEG.ELDNNSLI..FIKSL.....PMGIKL....KLSDYI.LKNL..VDDVNSNTNFsILsRIFDALGDyrC..FHN...YIlkilgGNTLSLDNLE
  742-  893 (163.32/63.60)	TGLFTN.FDRITElfILNYNR........ISMKYID.LNK...FWNL...M..LGV..........IKDD.KLQ.IE..VKQ...IINNN.......K.IFkDID...T.D........FLqkT.IL.ESS.....IeieFEDFISISNFH....NNFQVLIR..LIFNG.....ANSNDLiikrSILTLLkF.LK..R.......QN.FT.EFNKILFI..Y..IKKTYSNA.....NEIFR..QEP
  959- 1136 (284.63/116.77)	LTLFKNSIEDFTD..VLNNNNNNVKN.ENIQSDSTDILNN...FLSD...H..QHINKS.N..NSNYKNE.FLN.FF..LQN...LIYNQGL...VIK.IF.NIDE..N.DE.YRS..KFL..S.IL.NDA.....L...FSESITLSKSTIET.EDLSNLIK..LISNN.....INDLNL....PVFQLL.FKLK..MDVVKSNPQL.IL.EFFNSLTE..N..IKNDEGSI.....GSLFELVDDE
 1137- 1287 (140.04/53.40)	...MK...KKFIH..YLENLFLTSKKfPQISIDDTKIPLN...LISD...NliKLSKKF.E..KVELPDE.LL..FA..LDN...SL...EL...LLK.IV.NKSEftT.DL.YDSlgLFL..RiII.IHK.....A...FIIDIIVERNSIKE.TFLNNLVN..LLTSK.....FISQNL....PLKNLL.YD.............L.LL.SFKSNVNE.mN..ISN....................
 1288- 1373 (39.58/ 9.37)	....KSNIVKLPI..SLINLPA..............I........SE...N..STINHG.NqfNSNIHDEsIINdLY..IYNkssKTYNE.L...NVK.AF.DLVE..D......S..NPV..E.NL.NDTainlqL...FETSI.......................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.59|      20|      31|     227|     246|       2
---------------------------------------------------------------------------
  227-  246 (37.08/24.24)	WFVRCVGTNE...LRGLKRKGGA
  256-  278 (31.51/19.54)	WTLQVVEYIEklsLEYLKYENCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.50|      20|      22|     894|     915|       3
---------------------------------------------------------------------------
  894-  915 (28.54/21.47)	ILDLIVSELVPLNLvvDTFINF
  919-  938 (34.96/20.34)	IYTTIVKDLLFRDF..SEFKNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29975 with Med12 domain of Kingdom Fungi
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