Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MQDTFHQSLNNIVKILKSAPGSITIQNIQRLSNVYKFETFIENIDDKIKRLSIAGKILVIDIDYEELANKTKDQTKFELKDVKLILANNNNDFKYTSSVNGENILNNVLAKYSNFAQFDKALETLAVFDQYSNDDFDLFHYYIQIYEDLKKLTKIKVELNVNDEFAIVVEDQYKITLVNDERLCIVKNDHNGDQWNQQHDTKINDVGIKIEILNGFRIPISRNTLLQNNLVFDQNVKPISFFNNDDVFKSKTQSNFTLQGFQFLESEVLSISEVSTNDIKSVIITLEELIKFNKLNKVISELKEKFELIDKFANLEEDVRLNDFISENQDSIEVEQKFITISLKQTSIEIRSDNSDYNFTIPWSNEDGFDQGLEKLKRLLTA |
Length | 382 |
Position | Middle |
Organism | Wickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.409 |
Instability index | 32.39 |
Isoelectric point | 4.79 |
Molecular weight | 44380.50 |
Publications | PubMed=23193139 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29974 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.26| 14| 15| 157| 171| 1 --------------------------------------------------------------------------- 157- 171 (19.99/14.20) VELnVNDE.FAIVVED 175- 189 (20.27/ 9.44) ITL.VNDErLCIVKND --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.95| 21| 101| 220| 258| 2 --------------------------------------------------------------------------- 119- 140 (32.63/ 6.41) DKALETLAVFDQ......YSNDDfDLFH 223- 249 (32.32/39.04) NTLLQNNLVFDQnvkpisFFNND.DVFK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.10| 19| 25| 294| 312| 3 --------------------------------------------------------------------------- 294- 312 (31.19/16.72) KLNKVISELKEKFELIDKF 320- 338 (32.90/17.99) RLNDFISENQDSIEVEQKF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.57| 20| 79| 10| 37| 5 --------------------------------------------------------------------------- 10- 29 (33.20/31.46) NNIVKILK..SAPGSITIQNIQ 42- 63 (27.37/ 9.29) ENIDDKIKrlSIAGKILVIDID --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 29.59| 9| 16| 85| 95| 8 --------------------------------------------------------------------------- 85- 95 (13.21/11.58) ILanNNNDFKY 104- 112 (16.39/ 7.40) IL..NNVLAKY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GFDQGLEKLKRLLTA 2) YNFTIPWS | 368 357 | 382 364 |
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