<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29971

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDWRNELTNNERFRYVGVLVQALKELALTANNNNPNAFDLNKLKTSAEEFEKYCYTNASNRISYVHFFKQKILSIKNSIQQQNLQKQNQQNPQNQIPIQQGQQQGGQQPQQQGQGGQGQGQGQQVTPQLTAASINTNNNSQNQVFLAQQAQARLAAQQLRNQQPQQSTPQTQNNELNTNMNFQIQQQQQQPQGQQQQPQRPNQQGASQQGQNKGQSQGPSVNMKSIPIPLALLQRIPNLPPGVNTWQQIFELVASRQLESEYIGIIRQVYTIHTQLIQKQHQQFQKSLNSHDSKMGLNAQLSRQQQELRNRQLQQQQQQQQQQQQQQQQQQSQPQQPQQQVPPPPPQQQVPPSQPQAPQQTPGFVNPNASQIPQLTPELLQRLTENALRLLTKLQQEKQIPDNLTNEQRNMFIKRYISRQQQLRMEAFTKQQQQKGADTNDGVPTIINPQAQSQQQQQQQQVVNPTGSTQQQAPINQAQVQARLQQNAQNLSNDQQQQPPQQRWNNPNQPNSTTPANTNNNMRLNNLPTGLTPEQQQQLNAKRQQQALLHQKLQAQQQQKVQQQQQQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVPRPGGGVQSGPGGPQGGVQGPGVQGGPQNPLLKNNILIPTEQDRIELRMILNEVAKVPIRLTNLTNQLTNEQKSIVSSKIHNLLLPLFNLIEQLVPTFYTLTKNVDGTKKLLHMRFMVKEVLDGLRRDEYFASPELLEKVKAQSQKYVSFVKEQISRKNIATGGATGTTTGNEGGATNSQISGNNTTSSNFNNNNAAFNNNQVGNINPQITPQQLLQQRKQQQQQPAPLNPQITPQQLLQQQQQQQQQAQQQQLNQFQQPQPQPSQFINNLNNGSNDFNPMELTNLPNNNNGNFQNLDMNRINTPDLTQMNVTPKVAQLNVNQNVQNPSKFVAPSPALPTGNFVNTPNFSNSPQLINSQIYPQQQQQQVGQPQPFVPQSSVPPAPISANPPQQSMLNVSNSNAPTPQATGTSTGATKKQPAKRKSVKGRKQSAASTPSNAPKNAPTPGGSSFKSNDVQTPSGNVNSPLGTIAPSEIQKQLIKKEQEIVTKEEQSKKQFEDGQSKRLELYHSKPLDFFKASLANLLELKDEESKILSDSKKKTSGDLKNSPGQKGLTPSAILQTPLTFSNSAKTPNSTSKPISNPNQGGQIQGNSTYLSPNLSPSSSLKNSNNISDGSNWNIKVSKEAIKSTFANVEEIKKLMFDDEDSKDIIPTPPPEDKEKEEAKKRPNEELQDDRKFKKIKINDDNKFFDENDVELNNDLMWDFDYVSSHLDNSDEIQSEFF
Length1337
PositionTail
OrganismWickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.04
Grand average of hydropathy-1.160
Instability index65.95
Isoelectric point9.57
Molecular weight150534.56
Publications
PubMed=23193139

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29971
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.89|      20|      20|     569|     588|       1
---------------------------------------------------------------------------
  564-  583 (44.53/ 8.44)	QQQQSQQQQQQQQQQQQQQQ
  584-  601 (42.12/ 7.51)	QQQQQQ..QQQQQQQQQQQQ
  855-  874 (38.25/ 6.01)	QQQQQQQAQQQQLNQFQQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     879.28|     241|     282|     148|     428|       2
---------------------------------------------------------------------------
   84-  327 (381.11/62.94)	LQKQNQ.QNPQNQIPIQQGQQQ.GGQQPQ..QQGQG..GQGQGQGQQVTP....QLT..A..........ASINTN.NNSQNQVFL...............aqQAQARLAAQQLRNQQPQQSTPQTqNNELNTNMNFQIQQQQQQPqgQQQQPQRPNQQGASQ...........................QGQNKGQSQGPsVNMKsipiPLALLQRIPNL.......PPGVNTWQQIFEL..VASRQLESEYIG....IIRQVYTIH.TQLIQKQHQQFQKSLNSHDSKMGLNAQLSRQQQELrnrqLQQQQQQQQQQQQQQ
  328-  563 (294.36/56.42)	QQQQSQpQQPQQQVPPPPPQQQvPPSQPQapQQTPGfvNPNASQIPQLTPellqRLTenAlrlltklqqeKQIPDNlTNEQRNMFIkryISrQQQLRMEAF..............TKQQQQKGADT.NDGVPTIINPQAQSQQQQ...QQQQVVNPT..GSTQ...........................QQAPINQAQ...VQAR.......LQQNAQNLsndqqqqPPQ.QRWNN........PNQPNSTTPAntnnNMR.LNNLP.TGLTPEQQQQLNAK...............RQQQAL....LHQKLQAQQQQKVQQ
  794-  980 (203.81/25.21)	.........................................................................................IS.GNNTTSSNF.nNNNAAFNNNQVGNINP.QITPQ........QLLQQRKQQQQQP..APLNPQITPQQLLQQqqqqqqqaqqqqlnqfqqpqpqpsqfiNNLNNGSNDFN.........PMEL....TNL.......PNNNNGNFQNLDMnrINTPDLTQ..MN....VTPKVAQLNvNQNVQNPSKFVAPSPALPTGNFVNTPNFSNSPQLI........NSQIYPQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     114.49|      18|      18|     610|     627|       3
---------------------------------------------------------------------------
  603-  620 (29.89/ 8.83)	QQQQQQQQQQVPRPGGGV
  621-  636 (30.60/ 9.26)	QSGPGGPQGGVQGP..GV
  984-  999 (28.20/ 7.82)	QPQPFVPQSSV..PPAPI
 1060- 1077 (25.81/ 6.38)	PGGSSFKSNDVQTPSGNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.47|      34|      43|    1145|    1182|       4
---------------------------------------------------------------------------
 1016- 1059 (29.55/ 8.00)	AP....TPQATgtsTGATKKQPAKrksvKG......rkqsaaSTPSNAPKNAPT...
 1145- 1182 (50.99/25.73)	SKilsdSKKKT...SGDLKNSPGQ....KG............LTPSAILQTPLTFSN
 1184- 1228 (47.93/17.63)	AK....TPNST...SKPISN.PNQ....GGqiqgnstylspnLSPSSSLKNSNNISD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      14|      16|     670|     683|       5
---------------------------------------------------------------------------
  670-  683 (24.06/12.95)	VPIRLTNLTNQLTN
  689-  702 (22.16/11.36)	VSSKIHNLLLPLFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.11|      14|      28|    1249|    1276|       6
---------------------------------------------------------------------------
 1103- 1119 (17.53/ 6.62)	KE.......EQSKkqfEDGQSKRL
 1275- 1295 (16.57/16.11)	KEeakkrpnEELQ...DDRKFKKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29971 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FDDEDSKDIIPTPPPEDKEKEEAKKRPNEELQDDRKF
2) IQQQNLQKQNQQNPQNQIPIQQGQQQGGQQPQQQGQGGQGQGQGQQVTPQLTAASINTNNNSQNQVFLAQQAQARLAAQQLRNQQPQQSTPQTQNNELNTNMNFQIQQQQQQPQGQQQQPQRPNQQGASQQGQNKGQSQGPSVNMKSIPIPLALLQRIP
3) KDEESKILSDSKKKTSGDLKNSPGQKGLTPSAILQTPLTFSNSAKTPNSTSKPISNPNQGGQIQGNSTYLSPNLSPSSSLKNSNNISDG
4) LLTKLQQEKQIPDNLTNEQRNMFIKRYISRQQQLRMEAFTKQQQQKGADTNDGVPTIINPQAQSQQQQQQQQVVNPTGSTQQQAPINQAQVQARLQQNAQNLSNDQQQQPPQQRWNNPNQPNSTTPANTNNNMRLNNLPTGLTPEQQQQLNAKRQQQALLHQKLQAQQQQKVQQQQQQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVPRPGGGVQSGPGGPQGGVQGPGVQGGPQNPLLKNNILI
5) NIATGGATGTTTGNEGGATNSQISGNNTTSSNFNNNNAAFNNNQVGNINPQITPQQLLQQRKQQQQQPAPLNPQITPQQLLQQQQQQQQQAQQQQLNQFQQPQPQPSQFINNLNNGSNDFNPMELTNLPNNNNGNFQNLDMNRINTPDLTQMNVTPKVAQLNVNQNVQNPSKFVAPSPALPTGNFVNTPNFSNSPQLINSQIYPQQQQQQVGQPQPFVPQSSVPPAPISANPPQQSMLNVSNSNAPTPQATGTSTGATKKQPAKRKSVKGRKQSAASTPSNAPKNAPTPGGSSFKSNDVQTPSGNVNSPLGTIAPSEIQKQLIKKEQEIVTKEEQSKKQFEDGQSKRLELYH
6) QHQQFQKSLNSHDSKMGLNAQLSRQQQELRNRQLQQQQQQQQQQQQQQQQQQSQPQQPQQQVPPPPPQQQVPPSQPQAPQQTPGFVNPNASQIPQLTPELLQRLTENAL
1256
79
1141
390
772
280
1292
237
1229
651
1123
388










Molecular Recognition Features






MoRF SequenceStartStop




NANANA