<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29966

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAEESLISSLYPPPPAYYKFFTNENLEQFKEIKNNHKVEDDELHIPEDKKELEFLIPPRPPSGDTYRSFGNLWNVKEMGIPQLYQESNIPNDEEDSKIKIEELKRLLKSLLLNFLEIVGVMSVAPDQFATKIEHIRTILINIHHILNEYRPHQSRESLIFLLEKQVETKKDEIKEIERVCKEVETKIKGLIELYVDNQEKTSEQIKQESESFDDKKQVENNENAVKEES
Length229
PositionMiddle
OrganismWickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.07
Grand average of hydropathy-0.783
Instability index64.34
Isoelectric point4.92
Molecular weight26940.15
Publications
PubMed=23193139

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29966
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.54|      39|      43|      10|      51|       1
---------------------------------------------------------------------------
   10-   50 (70.35/43.80)	LYPP.PPA..YYKFFTN.........ENLEQFKEIKNNHkvEDDELHIPEDKK
   55-  105 (56.19/26.21)	LIPPrPPSgdTYRSFGNlwnvkemgiPQLYQESNIPNDE..EDSKIKIEELKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.69|      24|      53|     152|     175|       2
---------------------------------------------------------------------------
  152-  175 (37.83/25.62)	HQSRESLIFLLEKQVETKKDEIKE
  184-  206 (28.02/17.07)	ETKIKGLIELYVDNQEKTSEQIK.
  208-  227 (24.84/14.30)	....ESESFDDKKQVENNENAVKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29966 with Med7 domain of Kingdom Fungi
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