<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29956

Description Replicase polyprotein
SequenceMLQIESNAQTIIRLIEELLSVSRTLKESWILGQLPESREVEDPTIGISEKINKVLDNVLNSTKFEEEEEEEEEEEEEEKDDDDEKDDKEDGKDEEKEKESVEIKTESNDDQKNQEESIKKEDESKSIDIKEENKSDQTPQIEVKQESTENVQNEQKPNPQQDQQQDPQDQQQSNEYDLSNNNMIDNLGDSNFNDLDFDNFDHLNSNENNDDDIIMLD
Length217
PositionHead
OrganismWickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.03
Grand average of hydropathy-1.577
Instability index75.36
Isoelectric point4.05
Molecular weight25341.42
Publications
PubMed=23193139

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA-directed 5'-3' RNA polymerase activity	GO:0003968	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.14|      24|      25|      82|     106|       1
---------------------------------------------------------------------------
   82-  106 (36.09/16.47)	DDEKDDKEDGKDEEkEKESVEIKTE
  109-  132 (39.05/14.87)	DDQKNQEESIKKED.ESKSIDIKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.87|      15|      15|     144|     158|       2
---------------------------------------------------------------------------
  144-  158 (24.81/10.00)	KQESTENVQNEQKPN
  160-  174 (26.06/10.82)	QQDQQQDPQDQQQSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.39|      14|      15|     182|     196|       3
---------------------------------------------------------------------------
  182-  196 (20.96/16.59)	NmIDNLGDSNFNDLD
  199-  212 (26.43/15.23)	N.FDHLNSNENNDDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29956 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNVLNSTKFEEEEEEEEEEEEEEKDDDDEKDDKEDGKDEEKEKESVEIKTESNDDQKNQEESIKKEDESKSIDIKEENKSDQTPQIEVKQESTENVQNEQKPNPQQDQQQDPQDQQQSNEYDLSNNNMIDNLGDSNFNDLDFDNFDHLNSNENNDDDIIMLD
56
217










Molecular Recognition Features






MoRF SequenceStartStop




1) FNDLDFDNFDHLNSNENNDDDIIMLD
192
217