<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29953

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMDSNWIFDHPNSQASTPSGNINHPSSNAQTPIDHQSNHEFTPSQSHAFLNFDSPSNNSDFNPSNPNNNQNQSHTILNSVSSESHHQFNNEINSSLKNSNDSNHLHEWAQLPDFNDLDMNFFQNQHNNQQNNDHDQHTQQQSQAQQQTNGHHSIPPTPQSFDVTNYANSSNSSFIQNFQSPQLDSNPSSIQNQTSIRPDVVFTPLVSPAVTPLESMINQNQKHNGIGINTNGSNNNNFFSPLTSPALEAKSPMKYRKNSNSNSPDENQSNQTSSTATTKKKYKRKTPGNTPIVGPTIPGRIAKQSPIIKAKRSSSYVSSIHHHHHHQFQQPGGSSTSQSNTPLATTPTSGEYEMTPLPDPSVDQSINGSMAPPSSTNTTNSNTTTSNSIPTVTRRRSKKDSISSNGSGSNQPATPATLMNFKLESSNSPVILPSNGHQKSFSISQQQNGSISTHQQPQLSSHQRRPSEDSDTKKASHKLAEQGRRNRMNQAIMELGDLIPEQLQQTISIPSKATTVELATRYILELKEENRRLKEVLLVENASPNSITTFHDTISNEIPKELGRWSFELKIFKINNSTAQSSQSNFLYNLALSHEPHKAITLVNKSAIISNNDISKELIDSGCSNISIDSLDHIIQTKLQSLWLLRQTLKGENGNSYELLDGSLVLRTINVFLHGSFKAFLIEIEYKGKGDGLQKIKQFTEELNIPQGRLCTGMLNDKPSYLGDLSLQYTEALRF
Length734
PositionHead
OrganismWickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.06
Grand average of hydropathy-0.870
Instability index52.49
Isoelectric point6.78
Molecular weight81361.20
Publications
PubMed=23193139

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
protein dimerization activity	GO:0046983	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29953
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     323.65|      41|      42|     371|     411|       1
---------------------------------------------------------------------------
   15-   39 (31.30/ 6.77)	....STPSGN.INHPSSNA...QTPIDHQ................S..NH..........E
   62-  111 (41.05/11.30)	P.SNPNNNQN.QSHTILNS...VSSESHHQFNNE.INS..SLKN.S..NDsnhlhewaqlP
  126-  154 (30.53/ 6.41)	............NNQQNND...HDQHTQQQSQAQQ.QT..NGHH.S...I..........P
  155-  193 (33.21/ 7.66)	PtPQSFDVTNyANSSNSSF...IQNF.....QSPQLDS..NPSSiQ..NQ..........T
  197-  235 (43.93/12.64)	P.DVVFTPLV.SPAVT..P...LESMINQNQKHNGIGI..NTNG.S..NN..........N
  251-  290 (46.65/13.90)	P.MKYRKNSN.SNSPDENQ...SNQTSSTATTKKKYKR..KTPG....NT..........P
  371-  411 (65.56/22.69)	P.PSSTNTTN.SNTTTSNS...IPTVTRRRSKKDSISS..NGSG.S..NQ..........P
  418-  456 (31.44/ 6.83)	M........N.FKLESSNSpviLPSNGHQKSF..SISQqqNGSI.SthQQ..........P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.85|      36|      43|     485|     526|       2
---------------------------------------------------------------------------
  485-  526 (51.81/50.42)	NRMNQAIMELGDLIPEQL...QQTIS..IPSkattvELAtRYILELK
  529-  569 (53.04/35.11)	NRRLKEVLLVENASPNSIttfHDTISneIPK.....ELG.RWSFELK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29953 with Med20 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDSNWIFDHPNSQASTPSGNINHPSSNAQTPIDHQSNHEFTPSQSHAFLNFDSPSNNSDFNPSNPNNNQNQSHTILNSVSSESHHQFNNEINSSLKNSNDSNHLHEWAQLPDFNDLDMNFFQNQHNNQQNNDHDQHTQQQSQAQQQTNGHHSIPPTPQSFDVTNYANSSNSSFIQNFQSPQLDSNPSSIQNQTSIRPDVVFTPLVSPAVTPLESMINQNQKHNGIGINTNGSNNNNFFSPLTSPALEAKSPMKYRKNSNSNSPDENQSNQTSSTATTKKKYKRKTPGNTPIVGPTIPGRIAKQSPIIKAKRSSSYVSSIHHHHHHQFQQPGGSSTSQSNTPLATTPTSGEYEMTPLPDPSVDQSINGSMAPPSSTNTTNSNTTTSNSIPTVTRRRSKKDSISSNGSGSNQPATPATLMNFKLESSNSPVILPSNGHQKSFSISQQQNGSISTHQQPQLSSHQRRPSEDSDTKKASHKLAEQGRRNRMNQAIMELGD
1
496










Molecular Recognition Features






MoRF SequenceStartStop




1) PIIKAKR
2) PMKYRK
305
251
311
256