<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29952

Description Mediator complex subunit 12
SequenceMQTKDSLQKKRRERGLTSVVPQLGARHGARLFPAGPGRRLWRYGLGKMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPTGSGGCGSTIGPLPHDIEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGMSTHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKETEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTTSNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAPKTEDYGMGPGRSGPYGVTVPPDLLHHANPSSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYTGVLPTTMTGVMGIEPSYKTSVYRQQQPTVPQGQRLRQQLQQSQGMLGQSTVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQAPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRPQAFKWDLGTPGGGEAGALPGFDMMVNRVKPAPTPWSTPSTQ
Length2163
PositionKinase
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.07
Grand average of hydropathy-0.461
Instability index54.49
Isoelectric point7.28
Molecular weight241020.40
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29952
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      15|      16|    2073|    2088|       1
---------------------------------------------------------------------------
 2084- 2100 (28.30/15.07)	QQQQqqQQQQQQQQQQQ
 2101- 2115 (30.77/14.86)	QQQQ..QQYHIRQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     255.18|      40|     345|    1778|    1817|       2
---------------------------------------------------------------------------
  677-  705 (35.25/13.67)	............PGPR..................P...PSPFDDPADDSERKETEGS.SSSKL
  706-  763 (40.08/16.73)	EDPGlSESMDIDPSSSvlfedmekpdfslfsptmP...CEGKGSPSPEKPDVEKEVK.PPPK.
 1778- 1817 (69.59/35.37)	LRPR.PRAYYLEPLPL..................P...PEDEEPPAPTLLEPEKKAP.EPPKT
 1843- 1881 (58.64/28.45)	PAPK.TEDYGMGPGRS..................G...PYGVTVP.PDLLHHANPSS.ISHLS
 1882- 1923 (51.61/24.01)	YRQG.SIGLYTQNQPL..................PaggPR.VDPYRPVRL.PMQKLPtRPPYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      16|      17|     907|     923|       3
---------------------------------------------------------------------------
  907-  923 (26.03/19.48)	FALgMSYHLPLVQHVQF
  925-  940 (28.55/16.11)	FDL.MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.33|      30|     346|     256|     314|       4
---------------------------------------------------------------------------
  264-  299 (49.45/66.31)	GSTIGPLPHDIEV....AIRQWDYNEKLamfmfqDGMLDR
  498-  531 (47.88/13.85)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.95|      18|      18|    2009|    2026|       5
---------------------------------------------------------------------------
 1957- 1979 (24.98/11.22)	RLRQQLQQSQGMlgqstVHQMTP
 1980- 1993 (23.40/10.00)	SSSYGLQTSQGY.........TP
 2009- 2026 (34.35/18.43)	PTRHLQQRPSGY.....VHQQAP
 2030- 2047 (28.22/13.71)	HGLTSTQRFSHQ.....TLQQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.13|      55|     125|    1550|    1611|       6
---------------------------------------------------------------------------
 1550- 1611 (78.99/76.98)	SLySQVHQIVNNWRDDQYLDDCKPKQLMheaLKLRLNLVGGmFDTV......QRST.QQTTEWAvlLLE
 1679- 1740 (85.14/56.85)	SL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKIAG.FDSIfkkeglQVSTkQKISPWD..LFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      16|      17|    1278|    1293|       7
---------------------------------------------------------------------------
 1278- 1293 (28.25/14.19)	LGDAE.LKGSGFTVTGG
 1297- 1313 (24.57/11.41)	LPEEEgGGGSGGRRQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1075|    1087|       8
---------------------------------------------------------------------------
 1075- 1087 (25.11/16.28)	ENPAA.HTFTYTGL
 1093- 1106 (21.03/12.35)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      58|    1425|    1448|      15
---------------------------------------------------------------------------
 1425- 1448 (38.04/28.14)	SLLENIAKATIEVFQQSAETGSSS
 1486- 1509 (39.88/29.95)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      17|      22|     382|     401|      16
---------------------------------------------------------------------------
  385-  401 (32.74/20.69)	PTSSTPSTPFSDLLM.CP
  405-  422 (26.91/ 7.81)	PLVFGLSCILQTILLcCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.66|      21|     345|    1013|    1039|      21
---------------------------------------------------------------------------
  973-  994 (34.55/18.25)	CIVAVL.RHYHACLILnQDQMAQ
 1018- 1039 (34.12/21.15)	CILAYLyDLYTSCSHL.KSKFGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.26|      11|      23|    1612|    1622|      23
---------------------------------------------------------------------------
 1612- 1622 (20.16/13.76)	IIISGTV..DMQS
 1636- 1648 (15.10/ 8.19)	VLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      15|    1376|    1390|      24
---------------------------------------------------------------------------
 1376- 1390 (21.57/17.18)	HRLLDNEDgENPQRQ
 1393- 1406 (26.45/15.64)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29952 with Med12 domain of Kingdom Metazoa
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