<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29942

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDDIWRTSSFRHNVVNKIDEAIAQSGMPTSKNSLEMENHVFLKAKSKDEYLSFVARLLLHVGGRDMRGGNQMMNMNQNPGPVNATTLLQTLNNRPQTQNKLPGQMTMGPGQMNQGPPLRPSGPMGQGPMMQNSNAGPMGNQMGQGPPMPMSSVMGGQPMQGMPVQGMPVQSMPVQGMPVQGMSGVVPGNMPSNTMGRMQPRKMPVGPENVMMIPNQPVVGGYPAGPPRSVANNQFLSHNSPSSPQQSPVNVLPSGNQMIGSPSGPQLTPGGQMSGPIRSIGNVPSPGNSVPSLNTPMNPSSNAGPSPLAQEDIAYREKVRQLSKYIEPLRKMIAHIGNEDVEKLSKMKKLLEILSTPTQRMPLETLLKCETALERLDLSRGEGGSVPPPQSSTMREVHPLIEVIGSMIQSPNFNHTLHRTFAPCIEFMVGQRRPLSPPPYAGNENSNEVQSIIPKALEGEIARLDQRFKVSLDPVRPSGVSCIRLLCWLDDKNLPCVPPINIIVYENYPPANPACIISSNDYGGTSFLMCVKDVFESRMMLMPVRFTVSHILDSWEMSVRQAVALLLDNKDSIANN
Length578
PositionTail
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.04
Grand average of hydropathy-0.405
Instability index63.73
Isoelectric point8.75
Molecular weight62828.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.74|      27|      28|     113|     139|       1
---------------------------------------------------------------------------
   76-   97 (33.71/ 7.76)	NMNQN....P.GPVNATTLLQTLNNRP
  113-  139 (59.89/19.03)	QMNQGPPLRPSGPMGQGPMMQNSNAGP
  143-  161 (30.67/ 6.45)	QMGQGPPMPMSSVMGGQPM........
  281-  307 (40.46/10.67)	SIGNVPSPGNSVPSLNTPMNPSSNAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.77|      37|      48|     192|     230|       2
---------------------------------------------------------------------------
  164-  190 (33.49/ 8.18)	.............MPVQGMPVQ.....SM..PVQgmP.V..QGMSGVVPG
  192-  230 (70.55/29.53)	MPSNTMGrmQPRKMPVGPENVM.....MI..PNQ..PVV..GGYPAGPPR
  238-  280 (47.72/15.04)	LSHNSPS..SPQQSPV...NVLpsgnqMIgsPSG..PQLtpGGQMSGPIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.49|      39|      48|     352|     391|       3
---------------------------------------------------------------------------
  352-  391 (60.19/35.51)	LLEILSTPTQRMPLETLLKcETALERLDLSRGEGGSV.PPP
  402-  441 (67.29/35.20)	LIEVIGSMIQSPNFNHTLH.RTFAPCIEFMVGQRRPLsPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.77|      17|      20|     309|     326|       4
---------------------------------------------------------------------------
  309-  326 (25.95/24.89)	PLaQEDIAY..REKVRQLSK
  330-  348 (25.82/18.86)	PL.RKMIAHigNEDVEKLSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29942 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGRDMRGGNQMMNMNQNPGPVNATTLLQTLNNRPQTQNKLPGQMTMGPGQMNQGPPLRPSGPMGQGPMMQNSNAGPMGNQMGQGPPMPMSSVMGGQPMQGMPVQGMPVQSMPVQGMPVQGMSGVVPGNMPSNTMGRMQPRKMPVGPENVMMIPNQPVVGGYPAGPPRSVANNQFLSHNSPSSPQQSPVNVLPSGNQMIGSPSGPQLTPGGQMSGPIRSIGNVPSPGNSVPSLNTPMNPSSNAGPSPLAQEDIA
64
316










Molecular Recognition Features






MoRF SequenceStartStop




NANANA