<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29933
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAYSTSVNISIETQAENIIQEISYDGQEIYQPALSMSDNLSKLAQRIDFSKVDDDTKQQEVEIKSEEESKEPSPNVPISGWIDSVVSKLKRAATEICVISDVLAVTKEKRYMILDPIPTESIETKPMAQIYLRKKALASASNIIMSAVDRLRSSQNEFIRNRTTPDFHIELLRLRQNWRLKKVSTAIIGDLSYKTAGSKFGQSGMFEVTKAEDDVQSNTGTSSSSPSSSPSHNVSITKSPSALRVTVPTELQGVSYIMVLCQKDQENIFNTSFNLLGSAPATPNPDMHWQQKLEAAQNVLFCKELFNQLAKEAVQLQATIPHMVVGNQISATVFPGIQLIIGLCHSSTNGNPNAILPSKTDHDHVLEHSLHQLLREVHHRNTHQPFPHPSSGPLGPSKRRAVAGPNAADRFELLEMSKSQTLLEQIIEQAQHFFMRLRTEYVIDTLAKEVKDPIIISHWNSLNSPTQACVKVTIVSHGFDCICRTSLVVHVMKKSLKCICRDGRVMYLSYEPQELRDLIFCQIYQHQIMGVQSVAKTQGWQFLASSSHLGLGPVEPMGNASSCLLASPIGDRLISVKCEPQGNVSVSIAHSPKKDFFGGQLVKERKWENLGGSFKKVRWDKMEGKNFLNKIELLMASLTNST |
Length | 642 |
Position | Head |
Organism | Acyrthosiphon pisum (Pea aphid) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha>
Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.293 |
Instability index | 50.84 |
Isoelectric point | 7.92 |
Molecular weight | 71478.94 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29933
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.76| 13| 16| 472| 484| 1
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472- 484 (25.11/15.34) VTIVSHGFDCICR
489- 501 (23.65/14.06) VHVMKKSLKCICR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.05| 17| 262| 248| 268| 2
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248- 268 (26.11/25.90) PTELQGvsyiMVLCQKDQENI
512- 528 (32.94/20.81) PQELRD....LIFCQIYQHQI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.81| 20| 21| 542| 561| 3
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542- 561 (36.84/25.24) FLAS..SSHLGLGPVEPMGNAS
564- 585 (30.97/20.00) LLASpiGDRLISVKCEPQGNVS
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