<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29933

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAYSTSVNISIETQAENIIQEISYDGQEIYQPALSMSDNLSKLAQRIDFSKVDDDTKQQEVEIKSEEESKEPSPNVPISGWIDSVVSKLKRAATEICVISDVLAVTKEKRYMILDPIPTESIETKPMAQIYLRKKALASASNIIMSAVDRLRSSQNEFIRNRTTPDFHIELLRLRQNWRLKKVSTAIIGDLSYKTAGSKFGQSGMFEVTKAEDDVQSNTGTSSSSPSSSPSHNVSITKSPSALRVTVPTELQGVSYIMVLCQKDQENIFNTSFNLLGSAPATPNPDMHWQQKLEAAQNVLFCKELFNQLAKEAVQLQATIPHMVVGNQISATVFPGIQLIIGLCHSSTNGNPNAILPSKTDHDHVLEHSLHQLLREVHHRNTHQPFPHPSSGPLGPSKRRAVAGPNAADRFELLEMSKSQTLLEQIIEQAQHFFMRLRTEYVIDTLAKEVKDPIIISHWNSLNSPTQACVKVTIVSHGFDCICRTSLVVHVMKKSLKCICRDGRVMYLSYEPQELRDLIFCQIYQHQIMGVQSVAKTQGWQFLASSSHLGLGPVEPMGNASSCLLASPIGDRLISVKCEPQGNVSVSIAHSPKKDFFGGQLVKERKWENLGGSFKKVRWDKMEGKNFLNKIELLMASLTNST
Length642
PositionHead
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.06
Grand average of hydropathy-0.293
Instability index50.84
Isoelectric point7.92
Molecular weight71478.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.76|      13|      16|     472|     484|       1
---------------------------------------------------------------------------
  472-  484 (25.11/15.34)	VTIVSHGFDCICR
  489-  501 (23.65/14.06)	VHVMKKSLKCICR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.05|      17|     262|     248|     268|       2
---------------------------------------------------------------------------
  248-  268 (26.11/25.90)	PTELQGvsyiMVLCQKDQENI
  512-  528 (32.94/20.81)	PQELRD....LIFCQIYQHQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.81|      20|      21|     542|     561|       3
---------------------------------------------------------------------------
  542-  561 (36.84/25.24)	FLAS..SSHLGLGPVEPMGNAS
  564-  585 (30.97/20.00)	LLASpiGDRLISVKCEPQGNVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29933 with Med17 domain of Kingdom Metazoa
Unable to open file!