<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29930
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MASSSSSSPLEDLETQLEMFVENVRQIRIIVADFQPQGQTVLNQKIQNAVTGLQEINKLKSNVQDIHVPLEVFEYIDRGRNPQLYTKDCIEKALHKNEQVKGKIDALKKFKANVLTDLGQTFPNELNKYRALRSNCYGTSSVVAPPPPPPLNMLSSVTSLGGPNSQQQQQSLLGGSSLSIQQQQQQLNNASSIVSSASSCLTNSQQQSNSPNITSLLGCDGISTVSVGSNSNNIGGPPGT |
Length | 240 |
Position | Middle |
Organism | Acyrthosiphon pisum (Pea aphid) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha>
Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.451 |
Instability index | 59.03 |
Isoelectric point | 6.72 |
Molecular weight | 25867.68 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29930
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 145.88| 35| 38| 132| 168| 1
---------------------------------------------------------------------------
123- 162 (51.06/26.60) PNELNKyraLrsNCYGTSSVVAPPPPPPLNMLSSVTSLGG
163- 198 (46.29/19.34) PNSQQQqqsL....LGGSSLSIQQQQQQLNNASSIVSSAS
202- 236 (48.53/20.58) TNSQQQ.....sNSPNITSLLGCDGISTVSVGSNSNNIGG
---------------------------------------------------------------------------
|