<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29926

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPPTPLEDNQPNMSNGLPPEGSLPLSTMIDFIVQRTYHELTVLAELLPRKPDMERKIEVYKFSNRTRQLFVRLLALVKWANSASKVDKSTQIMGFLDKQSLLFIDTADMLSRVARETVVSARLPNFHIPSAVEVLTTGTFSRLPACIRERIVPPDKITPAEKRETLLQLNRVIQHRMVCSNLINEMSCKKVANGRVMFRVENEFQVSLTLMGDNPNIPWRLLDIEILVEDKETGEGKPLVHPRQVQYIHQVVQARLLECFSIGGEPLTQVYMVLHYFCQSLQLEVLFSQTRALYKDRLEGHIHLTEYTAGKCLVVSYWKELSRSVSEQFGYSLTIYVDDKEPNKPLGILHSPSLGIKDAEITEKSIGTDSLSMERLLVHTIHVRTKIRLSELKVELENLLKDVECTLQGSPSILSVAILNPCLRAEQLLITVDTHTGMLQCHVPEFSPPNMVVLKQALNNDHSKVPLLISDLRFWITQRRCETTLQHLPGTAYERLPLLHHADHPMSKISRHRMYIKLHKISNMIVIVEFAENEKSPCRIEYKFYLANVKKSSIEDNPNDESIEVDIPKMYLKVMTLLTIEKFVATHGPFTAVIEEDQEKMDPNSRKRVIVHPDKPRKLLKHPAYFIPELAHIVALCEERLPFTVLAQELTKCGISNQGVQVEANATSFVLKIVSLPPPSGIEATNSKWISLCKRVLSISIRVFGKGSTRCWTTEYVFYGSPLPSRHSREQGARRPVYINYDVSVAENMSKTVETILNDWSQIVHLYFLVEDLSPYLQSEKNNLASMISIKSYNYLKLIIGYGTHRPSTATIQWNSTSCKFNIVFGSLNSSINPHNLIKEQFEGYLNNNKKLSLLIHEMLDTLNPLAAICKLPSIPQLCVLHLPQVPVITFVVIANSTDLLKVIYEGQYCLEITLRWGNVVSIRDGAYSRYDRSSVISEYTPIPGLKTFLSKYVDETNVFRQRSQSEDDNPPSPITMECNFLSSSHRGPQSPAQGLRFHSAGNTTPGSNPHTPASPHPAVLSMSQNSQQQFNNSPVTSFNLASPPSAINPSPSMLPHPSPGSSLLASSPSNPLHVPSPAGMLPNSSPGPGSGFGLSSSTHPPEVSPFQSQSMTSPAASNWPGSPGLPRLSPARAQGQSPAGHSLQSPDHKSGYGHTSRVLPLKSWAGAVPTIITHEALNALCTPTAHPQGLPAPKQCPLERFLGCVYMRKNLQKFVETEENLIALVSKIKNPEPGVVYFQVETLQCRAFINMQHFQSLHLKISELKYSWNVEELNILEKFFESKVAIPPYKQNTLLGFTRMLSSPYTVLKDFIQIIKLEMIPGLVQQQQMKWAVQWILRIPPSATPIVPVGKEALLICRNKILFFLNITRIGITYNSNEVPSLVLPLIYDTATNLTQLAEKRDADPASAISAASLHMKRFAEFALNHNECSIFPAIRDLMSNFVLPSEPQPQMSSVSMNMHPQMTPGGPVPSPLMGEHMMNQNPSMVGQNPNMVVQNPNMAGPNPNMVGKNPNMVGQNPNMVRPGCKNYGNVPISDTRSQHGMMPNHQ
Length1548
PositionTail
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.07
Grand average of hydropathy-0.218
Instability index51.85
Isoelectric point8.59
Molecular weight173253.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29926
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.36|      23|      25|    1469|    1493|       1
---------------------------------------------------------------------------
 1449- 1469 (32.81/11.63)	.PQPQMSSVSMNMHPQMTPGGP.
 1470- 1492 (49.70/20.94)	VPSPLMGEHMMNQNPSMVGQNPN
 1495- 1513 (37.85/ 9.91)	VQNP....NMAGPNPNMVGKNPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     140.50|      19|      23|    1034|    1052|       2
---------------------------------------------------------------------------
  991- 1006 (24.05/ 7.83)	SPAQGLRF.....HSAGN.T..TP
 1034- 1052 (36.16/15.89)	SPVTSFNLASP..PSAIN.P..SP
 1059- 1078 (28.33/10.68)	SPGSSLLASSP..SNPLHvP..SP
 1088- 1110 (22.23/ 6.62)	GPGSGFGLSSSthPPEVS.PfqSQ
 1114- 1131 (29.74/11.61)	SPAAS.NWPGS..PGLPR.L..SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      19|      25|     139|     157|       3
---------------------------------------------------------------------------
  139-  157 (34.25/24.06)	TFSRLPACIRERIVPPDKI
  165-  183 (32.73/22.62)	TLLQLNRVIQHRMVCSNLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.62|      10|      30|    1204|    1213|       4
---------------------------------------------------------------------------
 1204- 1213 (20.40/15.92)	GCVYMR.KNLQ
 1235- 1245 (14.22/ 8.52)	GVVYFQvETLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.26|      22|      30|     236|     257|       5
---------------------------------------------------------------------------
  236-  257 (38.73/29.03)	GKPLVHP.RQVQYIHQVVQARLL
  264-  286 (34.53/24.93)	GEPLTQVyMVLHYFCQSLQLEVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.37|      10|      30|     942|     951|       6
---------------------------------------------------------------------------
  942-  951 (19.06/11.31)	PIPGLKTFLS
  974-  983 (20.31/12.60)	PITMECNFLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.10|      76|     369|     394|     505|       7
---------------------------------------------------------------------------
  376-  466 (109.26/68.53)	LLVHTIHV........................rtkirlselkVELENLLKDV.ECTLQGSPSILSVAILNPCL.RAEQL.LITVD....TH...TGMLQCHVPEFSPPNMvvlKQALNndHSKVP
  498-  616 (89.02/92.53)	LLHHADHPmskisrhrmyiklhkisnmivivefaenekspcrIEYKFYLANVkKSSIEDNPNDESIEVDIPKM.YLKVMtLLTIEkfvaTHgpfTAVIEEDQEKMDPNSR...KRVIV..HPDKP
  764-  813 (44.83/12.85)	..........................................VHLYFLVEDL.SPYLQSEKNNLASMISIKSYnYLK.L.IIGYG....THrpsTATIQ..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.53|      15|      20|     332|     347|      10
---------------------------------------------------------------------------
  332-  347 (22.02/21.22)	SLTIyVDDKEPNKPLG
  353-  367 (24.51/16.65)	SLGI.KDAEITEKSIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.05|      22|     375|    1136|    1170|      12
---------------------------------------------------------------------------
 1136- 1165 (33.88/45.30)	GQ..SPAGHSLQSPDHKSgyghtsrvLPLKSW
 1179- 1202 (37.17/16.48)	NAlcTPTAHPQGLPAPKQ........CPLERF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.23|      18|      30|      54|      71|      13
---------------------------------------------------------------------------
   54-   71 (29.13/16.02)	ERKIEVYKFSNRTRQLFV
   87-  104 (29.10/16.00)	DKSTQIMGFLDKQSLLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.24|      15|      23|    1253|    1270|      19
---------------------------------------------------------------------------
 1253- 1270 (22.97/25.37)	QHFQSlhlKISELKYSWN
 1279- 1293 (27.27/18.82)	KFFES...KVAIPPYKQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29926 with Med14 domain of Kingdom Metazoa
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