<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29922

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHSSHQTNGASLEDCHTNFFALTDLCGIKWRKFVHCSPGPEGPPDWGGGPGGGTNACGSVLEDPVLSSYTRCLTHDMLAVWRRVSLPPANSQQTSLDPLVPAPPTPIPALPPALSLKASKELWIFWYGEEPDLTGLVSPQLLLNEGDNGSWESGLSYECRSLLFKALHNLIERCLMSREFIRLGKWFVQPYSSSEKLDNLSASHLSFSFAFFVHGESTVCASIDVRQHSVVRTLSKEHLAQASSQPQSGSNIQVMLAPFGLAGTLTGHVYKNMDAETSRMMDEWSHFYPAVNNNGSNELSPAVEVLVGGVKMRYPSCYVLVTDLDDSTAELYKNQNTNQTTPQQQQQQQPPQLHQQPQQQIPKQQLFATKHQHHPDTIIYALDNAVASIPERAWQDCVLGPLHTEQNPPSRPESPTIGQWHLSDPLQKLTCSCTRSTRLCPTDSPCGLDSVPPLPSVPTPPSAGQPAPLSIPPPMLSPHDEKIPITPLSVDFQPKSVSSVSNQVFSPYPSSAPASQEPVKSGRESNSGTPAPPSNTVSIPATTPTATTPVPMQTQSSSAYITLKRPQLSSKDYEANLVEEEIMPSKLLYDYSCIDAWLYHPVKKFKPIVPKQEPITRINNVTDNPASPPQVYIRRDTSVPILPVEPSEISINNFSSFEELRNNALRFKGGRSDPYEFDEESGACSSNNIMMSSDYKLNTSMAVMKNEDIKKEYDPGLMNGNRCTSDSMRDLDHMFDNSDDLSSDEAVAALQMQTPPGSNKPDDCLGGGLTTLLVRPPRGSGGGSGGGVLRPEELVKMFPTPPSLEHNPIASPCPDIDLLPPRTYQTNSYMGSPQHDHIEDWSYVYKPPAIAKMVGSSKYAPLTNLPSQNLSPITVPSYKPSSFVYHASSQPQQIQHHPPQPEKPNQIVPSPASSANNNLLPNMNRNNHYHHPIMMSPSPHSTPWPGGGNQYHRPPQQQIQQHQQVPPPPYSPALSQHHNMNVVPTNMSPPVPEANSIVVNVLLTDSLLNVFRDHNFDSCTLCVCNAGPKVVGNIKGTDAAVYLTHTLTPNGYSSQYQQHHMSVGIPGDEDGIRCSCGFSAVVNRRLSHKSGLFPEDEAEITGLIEDSPARVDDNSMNPDVLELVREQCAAVIYSSCSSLVRAAAKFPINHPPQTATVNMLEFTDTNQVALLALEQGRLAKLEGGMNNHWQVEHHRWPGHHQQSLPPLNNNSPPVHRWAYSQAPGPRSSRQLIRVMRTLQPLLQEAIQRRSVTSRLWEPYTVTGPLTWRQFHRLAGRGTDDRCEPQPIPPILVGHDKDWVAVAPLALHYWDKLLLEPFSYSRDVAYIVVSPDNEFILQRTRAFFKELSAAYEINRLGRHCPITKVLRDGILRVGKSAAAKLAKEPVDEWFSMLGENHQSSMLKLYAQVCRHYLAPQLSQFSMDKTLLDPPEGSIPRPPPSPMPPPASLTPNSVESPVSSNERAPTPKSDGLDDSSSGSQADKSFNSNGDNSHCEEDDGEVPAIVIYLVEPFSIGKDSSNLARIACHGLLRCYNTVLATLPEAIRSNISVQLISLESVLELGRSSDHLKMSDNMRTLALSVFSQCRRYLTHTANIKALTGFGTAAMTELFLKNKDEKSRTAYKAYTPPFILASYRNNKTGRTDSGLAGDNGGGDSLSTLGGSNGTGSPSGTDQQCSVLYASYCISEDQRWILATATDEQGILLETATINIYVPNNRRRKSPARRVGLQKLMDFILGVMSQSVTPWRLVVGRVGRIGHGELKGWSWLLSRKALMKASRHLKESCGQCSLLYQKSDVPSVVSACLVSLEPDSSLRLMTDQFTPDERFSQASVACQLSTPRDVSATHILVFPTSATTQSSQTAFQEQQINGPELGDDELFSAFNEEDMQSMEGMGDFNDIFSTWNDSDAVGNTSLGLPSSGVSGVLGGPSSNVIGGVMGSGSLGGSIGMSRGSMGPRGDCSSQPGSPPSSQPCSPYTCGSSSYRNGGSCIDGHEEVGALLQQPLALGYLVSTAPTGRMPTWFWASCAPDIEKCSPAFLKSALHMHTVQLPNNADPAAADLLHPTSAVSAHPLDSQYTTDVLRYVLEGYNALSWLSLDSNTHDRMSCLPIHMQVLMQLYHTMNALI
Length2121
PositionMiddle
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.07
Grand average of hydropathy-0.420
Instability index59.25
Isoelectric point5.90
Molecular weight231890.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29922
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.88|      18|      18|    1866|    1883|       1
---------------------------------------------------------------------------
 1866- 1883 (33.14/21.11)	NGPE.LGD.DELFSAFNEED
 1885- 1904 (26.74/15.49)	QSMEgMGDfNDIFSTWNDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.05|      42|      61|     456|     497|       2
---------------------------------------------------------------------------
  402-  446 (40.38/ 9.47)	PLHTEQNP..............P.SRPE...S......PTIG.QWHLS....DPlqkltcsctrstrlCPTDS.P..........................
  456-  487 (54.06/14.89)	......................P.SVPT...P......PSAGQPAPLS....IP..............PPMLS.PH..................DEKIPIT
  488-  549 (39.34/ 9.06)	PLSVDFQPKSvssvsnqvfspyPsSAPAsqePvksgreSNSGTPAP.......P..............SNTVSiPA..................TTPTATT
  550-  617 (32.28/ 6.26)	PVPMQTQSSS..........ayI.TLKR...P....qlSSKDYEANLVeeeiMP..............SKLLY.DYscidawlyhpvkkfkpivPKQEPIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.91|      18|      20|     968|     987|       3
---------------------------------------------------------------------------
  876-  894 (23.18/ 7.85)	VPSYKPSsFVYHASSQ..PQQ
  968-  987 (33.73/21.01)	PPPYSPA.LSQHHNMNvvPTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.52|      17|      20|     756|     775|       4
---------------------------------------------------------------------------
  756-  775 (24.95/16.86)	PPGSNkpDDClGGGL..TTLLV
  778-  796 (26.57/ 8.48)	PRGSG..GGS.GGGVlrPEELV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.18|      18|      20|     915|     933|       5
---------------------------------------------------------------------------
  915-  932 (32.61/ 9.61)	SANNNLLPNMNRNNHYHH
  937-  954 (40.57/16.00)	SPSPHSTPWPGGGNQYHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.34|      12|      18|    1468|    1481|       8
---------------------------------------------------------------------------
 1468- 1481 (16.47/15.11)	SDGldDSSSGSQAD
 1486- 1497 (23.87/14.20)	SNG..DNSHCEEDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     442.21|     148|     897|    1028|    1202|       9
---------------------------------------------------------------------------
 1028- 1202 (231.84/183.03)	GP..KVVGNIKGTDA....avylthTLTPNG.YSSQyqqhhmsvgiPGDEDGIR.CS...CGFSAVVNRRL...SHKS.GLFPEDEAEITGLIEDSP.ARVDD...NSMNPDVlelvrEQCAAVIYSscSSLVRAAAKFPINHPPqtATVNMLEftDTNQVALLALEQGRLAK.....LEGGMNNHW....QVEHHRW...PGHHQ
 1924- 2108 (210.37/118.04)	GPssNVIGGVMGSGSlggsigmsrgSMGPRGdCSSQ..........PGSPPSSQpCSpytCGSSSYRNGGScidGHEEvGALLQQPLALGYLVSTAPtGRMPTwfwASCAPDI.....EKCSPAFLK..SALHMHTVQLPNNADP..AAADLLH..PTSAVSAHPLDSQYTTDvlryvLEGYNALSWlsldSNTHDRMsclPIHMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      14|      16|     626|     639|      10
---------------------------------------------------------------------------
  626-  639 (25.72/14.35)	PASPPQVYIRRDTS
  644-  657 (24.26/13.05)	PVEPSEISINNFSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.62|      11|      16|     269|     279|      11
---------------------------------------------------------------------------
  269-  279 (19.63/12.41)	HVYKNMDAETS
  287-  297 (20.99/13.86)	HFYPAVNNNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.74|      16|      16|     712|     727|      12
---------------------------------------------------------------------------
  712-  727 (30.29/20.10)	KEYDPGLMNGNRCTSD
  730-  745 (28.44/18.34)	RDLDHMFDNSDDLSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.33|      14|     104|     800|     813|      13
---------------------------------------------------------------------------
  800-  813 (28.23/11.36)	PTPPSLEHNPIASP
 1443- 1456 (25.10/ 9.19)	PPPASLTPNSVESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.90|      16|     545|     348|     363|      16
---------------------------------------------------------------------------
  348-  363 (33.25/16.77)	QQQPPQLHQQPQQQIP
  896-  910 (31.63/15.55)	QHHPPQPE.KPNQIVP
  955-  967 (22.01/ 8.23)	...PPQQQIQQHQQVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      19|      22|    1556|    1577|      17
---------------------------------------------------------------------------
 1556- 1576 (27.31/22.28)	SVLELGRSsdHLKMSDNMRTL
 1579- 1597 (33.16/15.47)	SVFSQCRR..YLTHTANIKAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.11|      25|     144|      10|      36|      21
---------------------------------------------------------------------------
   10-   36 (39.29/36.41)	GASLEdCHTNFF.ALTDL...CGIKwRKFVH
  155-  183 (37.82/23.25)	GLSYE.CRSLLFkALHNLierCLMS.REFIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.64|      19|     107|    1303|    1321|      23
---------------------------------------------------------------------------
 1303- 1321 (37.12/21.76)	AP.LALHYWDKLLLEPFSYS
 1414- 1433 (31.52/17.22)	APqLSQFSMDKTLLDPPEGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29922 with Med13 domain of Kingdom Metazoa
Unable to open file!