<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29921

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSGFPSSYSPKSSPRGARSPVVSRQDSTGTLKTTISLGKNPSIVHSGPFYLMKEPPCESELTGSVNLMAYYGLEHTYSKFSGKRLKESLSSFLPNLPGIIDTPGHNDQSSLRSVIEKPPIGGKEILPLTTHQLAGFRLHPGPLPEQYRYANQPPTKKHKNKHKKSKYKSGEALSLDMAANELGLGDIHEKKHKKQKRHDDDKERKKRKKEKKKKKQKHSPEHPGNITPGQHSN
Length233
PositionHead
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.06
Grand average of hydropathy-1.116
Instability index61.03
Isoelectric point9.94
Molecular weight26000.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.77|      77|      85|       6|      89|       1
---------------------------------------------------------------------------
    6-   85 (124.33/72.66)	SSYSPkSSPRGARSPVVSRQDSTGTL..KTTISlGKN..PSIVHS.GPFYLMKEP.PCESELTGSVNLMAYYGlEHTYSKF.SGKRL
   90-  173 (118.45/53.70)	SSFLP.NLPGIIDTPGHNDQSSLRSVieKPPIG.GKEilPLTTHQlAGFRLHPGPlPEQYRYANQPPTKKHKN.KHKKSKYkSGEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.69|      12|      18|     189|     201|       2
---------------------------------------------------------------------------
  189-  201 (19.07/13.58)	EKKHKKQKrHDDD
  210-  221 (22.62/11.42)	EKKKKKQK.HSPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29921 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFPSSYSPKSSPRGARSPVVSRQDSTGTLKTTISL
2) LPGIIDTPGHNDQSSLRSVIEKPPIGGKEILPLTTHQLAGFRLHPGPLPEQYRYANQPPTKKHKNKHKKSKYKSGEALSLDMAANELGLGDIHEKKHKKQKRHDDDKERKKRKKEKKKKKQKHSPEHPGNITPGQHSN
3
96
37
233










Molecular Recognition Features






MoRF SequenceStartStop




1) DIHEKKHKKQKRHDDDKERKKRKKEKKKKKQKHSP
186
220