<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29918

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPPTPLEGNQPNMSNGLPPDGSLSLSVLIDFIVQRTYHELTVLAELLPRKPDMERKIEIYKFSNRTRQLFVRLLALVKWANSASKVDKSTQIMGFLDKQSLLFIDTADMLSRVARETVVSARLPNFHIPSAVEVLTTGTFSRLPACIRERIVPPDKITPAEKRETLLQLNRVIQHRMVCSNLINEMSCKKVANGRVTFRVENEFQVSLTLMGDNPNIPWRLLDIEILVEDKETGEGKPLVHPRQVQYIHQVVQARLLECCSTGGEPLTQVYMVLHYFCQSLQLEVLFSQTRALYKDRLEGHIHITEYTAGKCLVVSYWRELSRSVSEQFGYSLTIYVDDKEPNKPLGILHSPSLGTKDAEITEKSIGTDSLSMERLLVHTIHVRTKIRLSELKVELENLLKDVECTLQGSPSILSVAILNPCLRAEQLLITVDTHTGMLQCHVPEFSPPSMVALQQALNNEHSKVPLLISDLRFWITQRRCETTLQHLPGTAYERLPLLHHADHPMSKISRHRMYIKLHKISNMIVIVEFAENEKSPCRIEYKFYLANVKKSSIEDNPNDESIEVDIPKMYLKVMTLLTIEKFVATHGPFTAVIEEDQEKMDPNSRKRVIVRPDKPRKLLKHPAYFIPELAHIVALCDERLPFTVLAQELTKCGISNQGVQVEANATTFVLKILSLPPPSGIEASNPKWISLCKRVLSISIRVYGKGSTRCWTTEYVFYGSPLPSRHSREQGARRPVYINYDVSVAENMSKTVETILNDWSQIVHLYFLVEDLSPYLQSEKNNLASMISIKSYNYLKLIIGYGTHRRSTATIQWNSTSCKFNIVFGSLNSSINPHNLIKEQFEGYLNNNKKLSLLIHEMLDTLNPLTAICKLPSIPQLCVLQLRPQVPVITFGVVANSTNLLKVIYEGQYCLEITLRWGNLVSIRDGAYSRYDRTSVISEYTPTPGLKAFLSKYVDETNVFRRRSQSEDDNPPSPITMDNVEGNFLSSSHRGPQSPAQGLRFHSAGNTTPGSNPHTPASPHPAVSSMSQNSQQQFNNSPVTSFNLASPPSAINPSPSMLPHPSPGSSLLASSPSNPLHVPSPAGMLPNSSPGPGSGFGLSSSTHPPEVSPFQSQSMTSPAASNWPGSPGLPRLSPARAQGQSPAGHSLQSPDHKSGYGHTSRVLPQKSWAGAVPTIITHEALNALCTPTAHPQGLPAPKQCPLERFLGCVYMRRNLQRFVQTEENLIALSSSEPGVVNFKVETLQCRAFINMQHFQSLHLKISCIPEQKDPWNVEELNILEKFFESKVAIPPCKPNTLLGFTRMLNCPYTVLKDFIQIIKLEMIPGLIQQQQMKWTVQWCLRIPPSATPIVPVGKEALLICRNKILFFLQITRIGITYNSNEVPSLVLPLVYDTATNLTQLAEKRDAGPASAISAASLHMKRFAEFALNHNECSIFPAIRDLMSNFVLPSEPQPQMSPASMNMHPQMTPGGPVPSPLMGQHMMNQNPNMVGPNPNMGGPNPNMVGPNPNMVGQNPNMVVQNPNMVGPNPNMVGQNPNMVGQNPNMVGPGCNNYGNVPMSAMGPQHGMMPNHQ
Length1572
PositionTail
OrganismAcyrthosiphon pisum (Pea aphid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Aphidomorpha> Aphidoidea> Aphididae> Macrosiphini> Acyrthosiphon.
Aromaticity0.07
Grand average of hydropathy-0.249
Instability index52.93
Isoelectric point8.64
Molecular weight175206.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29918
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     211.97|      25|      25|    1493|    1517|       1
---------------------------------------------------------------------------
 1044- 1063 (26.75/ 8.75)	..NLASP.P.SAINPSPSML.PHPS.
 1470- 1489 (37.33/15.33)	....GGPVP.SPL.MGQHMMNQNPNM
 1493- 1517 (57.86/28.10)	NPNMGGPNP.NMVGPNPNMVGQNPNM
 1521- 1545 (54.64/26.10)	NPNMVGPNP.NMVGQNPNMVGQNPNM
 1549- 1570 (35.38/14.12)	GCNNYGNVPmSAMGPQHGMM...PN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     150.42|      24|      25|    1106|    1129|       2
---------------------------------------------------------------------------
 1083- 1113 (31.48/10.97)	AGML.PNSSPGP.GS.GfglsssthpPEV...SPFQS
 1114- 1138 (41.13/16.51)	QSMTSPAASNWP.GSPG........lPRL...SPARA
 1139- 1159 (25.09/ 7.31)	QGQ.SPAGHSLQ..SP.............dhkSGYGH
 1160- 1181 (26.05/ 7.86)	TSRVLPQKS.WA.GA..........vPTI...ITHEA
 1183- 1204 (26.66/ 8.21)	NALCTPTAH..PqGLPA.........PKQ...CPLE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.91|      26|      28|     227|     253|       3
---------------------------------------------------------------------------
  227-  253 (43.16/35.83)	LVEDKETGeGKPLVHPRQV.QYIHQVVQ
  256-  282 (46.75/33.63)	LLECCSTG.GEPLTQVYMVlHYFCQSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.72|      19|      23|     983|    1004|       4
---------------------------------------------------------------------------
  983- 1002 (32.05/17.45)	GNFLSSSHRGPQ.SPAqGLRF
 1006- 1018 (20.46/ 6.96)	GNTTPGSN..PH.TPA.....
 1445- 1463 (26.21/11.09)	.NFVLPSEPQPQmSPA.SMNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.07|      25|      28|     543|     570|       5
---------------------------------------------------------------------------
  545-  569 (42.37/27.30)	YLANVKKSSIE.....DNPNDESIEVDIPK
  571-  600 (36.70/20.83)	YLKVMTLLTIEkfvatHGPFTAVIEEDQEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      19|      28|     139|     157|       6
---------------------------------------------------------------------------
  139-  157 (34.25/19.90)	TFSRLPACIRERIVPPDKI
  165-  183 (32.73/18.70)	TLLQLNRVIQHRMVCSNLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.73|      15|      28|     454|     468|       7
---------------------------------------------------------------------------
  454-  468 (25.18/14.80)	LQQALNNEHSKVPLL
  485-  499 (26.54/16.03)	LQHLPGTAYERLPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.31|      15|      32|    1239|    1257|       9
---------------------------------------------------------------------------
 1239- 1257 (22.32/17.03)	FKVETLQcrafINMQHFQS
 1272- 1286 (24.99/ 9.66)	WNVEELN....ILEKFFES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.58|      31|     460|     388|     440|      10
---------------------------------------------------------------------------
  405-  440 (43.69/56.74)	CTLqgsPSILSVAILNpcLRAEQLLIT...VDTHTGMLQ
  870-  903 (50.89/20.06)	CKL...PSIPQLCVLQ..LRPQVPVITfgvVANSTNLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.31|      15|      17|     826|     840|      11
---------------------------------------------------------------------------
  826-  840 (26.36/18.30)	GSLNSSINPHNLIKE
  844-  858 (25.94/17.87)	GYLNNNKKLSLLIHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.40|      21|      24|     706|     729|      15
---------------------------------------------------------------------------
  706-  729 (36.06/35.03)	KGSTRCWtteYVFYGSPLPSRHSR
  731-  751 (36.34/25.56)	QGARRPV...YINYDVSVAENMSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29918 with Med14 domain of Kingdom Metazoa
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