<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29908
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSTELQSGKVLEGGAVRSSAGVPGERFPASPQLRSPSDSVSVDGGPVQGQVSQVSSETVGAVSGVKAVPPPLPHVEINQVSLAVIVRNLTVFTIKEIVQYMKTNVHSSPEQGTLLRKVNFLQLIIYLRNQFLRLYVLVKWARTIKDNNFNVLIDLLNWFRNTNVSVNNCIWALKGTLASMANAKLPNVDLVTALEVLSLGRPNLPTHNFKLSGEKQTLEIPPELILQRLKDLNLTVSIKIALMDLPTQFKDYRIANGRIYIFVQDEFEIQLSTIDSHAPLFFVDLDLLFHYRDSKTGDHMNNGGTAQDDNTAAAHKTANYLPLNKRKLEKLINDLLRKSDKPFFALYKFLHKYVLTLKLYMVHMELTNLETTVKFSGGNLVHSYDAKKSIISGRYWLNAKMGNRGKYTIGVDRYTEMLVLRWDNDATKLKSMRMPTVYKRILGNVESILDEIMFNHANLIKSELLSRGIFEDDEDDPNVLLLQVPTTCISNAPVQLKIDLITGLFYFKNPSSLLSSYTKKINAADSPEELTRTLLQLKLDKITHILKNMFEKTGWICNSSIKLPNLIPTQLMKTADTESTELGLTNGKSMAGSLLQFDLFVCLPNWPVNWYLILTIISSDSSCVIEKRMGKIVSQKNKWHLSYLDQSGVTSYKLEALTYQKIMSLQKTILHRIVNHTLIDSLNQLKIRNHVCSADVVSNLLPDYIVKESEIKDEQGDLDMDSVAANKEDYTSIIDLELESFLEGSKALNGILENSMFMRINYAKSETRLYARFKRDTMIKQVQCNDLLIHFVPEDPLAFYLDEKFSDLSHIISDLATFRKKLMQLVVLTDVVERLHKNFASEWFKIVALKPNEIAFKYLHDTSEKADCTITIITSDSTVKNLDIELAKSNPQCIIQPLINTGKVDYHFIFHYLQFTSSFFSTLQKVLVPEDDTSDEGAPTFTQIHLGVHSLREYQLVYHNPISGTKITVIIELKSVCHNNRMKMQYYIHFSREEHVTAKSPAYPLIHAIRNQIFMLDMKQYPHPQQQQQPATVDTKYPKAVRLLDGIACDAADVGPILLDIHSILRMDSNTDLNGVV |
Length | 1077 |
Position | Tail |
Organism | Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Kazachstania.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.142 |
Instability index | 37.42 |
Isoelectric point | 7.39 |
Molecular weight | 122129.59 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi
TFIIB-class transcription factor binding GO:0001093 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP29908
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 119.66| 37| 40| 495| 533| 1
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495- 533 (57.91/38.83) QLKIDLITGLF..YFKNPSSLLSSYTKKINAAdsPEELTRT
536- 574 (61.75/35.67) QLKLDKITHILknMFEKTGWICNSSIKLPNLI..PTQLMKT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.58| 29| 40| 76| 104| 2
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76- 104 (45.76/29.31) EINQVSLAVIVRN..LTVFTIKEIVQYMKTN
117- 147 (42.83/27.01) KVNFLQLIIYLRNqfLRLYVLVKWARTIKDN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.51| 15| 45| 14| 32| 3
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14- 32 (22.39/25.95) GAVRSSAGVPgerfPASPQ
60- 74 (29.12/19.47) GAVSGVKAVP....PPLPH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.41| 23| 220| 421| 462| 4
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438- 462 (31.57/53.45) YKRILGNVESILDEIMfNHaNLIKS
659- 681 (40.84/16.19) YQKIMSLQKTILHRIV.NH.TLIDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 154.47| 46| 508| 251| 298| 9
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251- 298 (76.51/53.21) DYRIANGRIYI.FVQDEFEIQLSTIDshAPLFFVDLDLLFHYRDSKTGD
761- 807 (77.97/47.95) NYAKSETRLYArFKRDTMIKQVQCND..LLIHFVPEDPLAFYLDEKFSD
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