<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29908

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSTELQSGKVLEGGAVRSSAGVPGERFPASPQLRSPSDSVSVDGGPVQGQVSQVSSETVGAVSGVKAVPPPLPHVEINQVSLAVIVRNLTVFTIKEIVQYMKTNVHSSPEQGTLLRKVNFLQLIIYLRNQFLRLYVLVKWARTIKDNNFNVLIDLLNWFRNTNVSVNNCIWALKGTLASMANAKLPNVDLVTALEVLSLGRPNLPTHNFKLSGEKQTLEIPPELILQRLKDLNLTVSIKIALMDLPTQFKDYRIANGRIYIFVQDEFEIQLSTIDSHAPLFFVDLDLLFHYRDSKTGDHMNNGGTAQDDNTAAAHKTANYLPLNKRKLEKLINDLLRKSDKPFFALYKFLHKYVLTLKLYMVHMELTNLETTVKFSGGNLVHSYDAKKSIISGRYWLNAKMGNRGKYTIGVDRYTEMLVLRWDNDATKLKSMRMPTVYKRILGNVESILDEIMFNHANLIKSELLSRGIFEDDEDDPNVLLLQVPTTCISNAPVQLKIDLITGLFYFKNPSSLLSSYTKKINAADSPEELTRTLLQLKLDKITHILKNMFEKTGWICNSSIKLPNLIPTQLMKTADTESTELGLTNGKSMAGSLLQFDLFVCLPNWPVNWYLILTIISSDSSCVIEKRMGKIVSQKNKWHLSYLDQSGVTSYKLEALTYQKIMSLQKTILHRIVNHTLIDSLNQLKIRNHVCSADVVSNLLPDYIVKESEIKDEQGDLDMDSVAANKEDYTSIIDLELESFLEGSKALNGILENSMFMRINYAKSETRLYARFKRDTMIKQVQCNDLLIHFVPEDPLAFYLDEKFSDLSHIISDLATFRKKLMQLVVLTDVVERLHKNFASEWFKIVALKPNEIAFKYLHDTSEKADCTITIITSDSTVKNLDIELAKSNPQCIIQPLINTGKVDYHFIFHYLQFTSSFFSTLQKVLVPEDDTSDEGAPTFTQIHLGVHSLREYQLVYHNPISGTKITVIIELKSVCHNNRMKMQYYIHFSREEHVTAKSPAYPLIHAIRNQIFMLDMKQYPHPQQQQQPATVDTKYPKAVRLLDGIACDAADVGPILLDIHSILRMDSNTDLNGVV
Length1077
PositionTail
OrganismKazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.08
Grand average of hydropathy-0.142
Instability index37.42
Isoelectric point7.39
Molecular weight122129.59
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.66|      37|      40|     495|     533|       1
---------------------------------------------------------------------------
  495-  533 (57.91/38.83)	QLKIDLITGLF..YFKNPSSLLSSYTKKINAAdsPEELTRT
  536-  574 (61.75/35.67)	QLKLDKITHILknMFEKTGWICNSSIKLPNLI..PTQLMKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.58|      29|      40|      76|     104|       2
---------------------------------------------------------------------------
   76-  104 (45.76/29.31)	EINQVSLAVIVRN..LTVFTIKEIVQYMKTN
  117-  147 (42.83/27.01)	KVNFLQLIIYLRNqfLRLYVLVKWARTIKDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.51|      15|      45|      14|      32|       3
---------------------------------------------------------------------------
   14-   32 (22.39/25.95)	GAVRSSAGVPgerfPASPQ
   60-   74 (29.12/19.47)	GAVSGVKAVP....PPLPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.41|      23|     220|     421|     462|       4
---------------------------------------------------------------------------
  438-  462 (31.57/53.45)	YKRILGNVESILDEIMfNHaNLIKS
  659-  681 (40.84/16.19)	YQKIMSLQKTILHRIV.NH.TLIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.47|      46|     508|     251|     298|       9
---------------------------------------------------------------------------
  251-  298 (76.51/53.21)	DYRIANGRIYI.FVQDEFEIQLSTIDshAPLFFVDLDLLFHYRDSKTGD
  761-  807 (77.97/47.95)	NYAKSETRLYArFKRDTMIKQVQCND..LLIHFVPEDPLAFYLDEKFSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29908 with Med14 domain of Kingdom Fungi
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