<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29907
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSDEQGINLALDPNLITLPLNGSTGTTTTSPLEMDTAAGTDTTAKPKVSLVDNPHEMYGQMPLAQLVPLILQQRQIPFSQLLEQNIINSMSGDEQPFIPEEQTVDMAESGALNNRRGQDETFASIRANMVEQTNVALNEASLALETVALLLSATRESNAKASISPFLKNTVPLRSLNSDSVLQQPSEPLDDLKFALGWKLKCLDDCKNKLRREVDTLRATLEREHLYWRKIGQYIKNSDVVFKMRDKSTGLKAIALKFGYEDSGSAYRYDRGIAILRNRPESDMLELVPVASTRDGPRGFQEKLLRVRIFTKIASEEDYIFSGESTLQDNAEGSVFNNENIRGQISKLKDIIFEKELMYQLKRECAPLISYGVSIENENKVVMELPNEKFEIELVSCDESSMANHDHDNPRTNDRRANLFLITLRMLLIVQFKKNIRRGLAMNVSSSRRGPEDILLLRPLLAKLRHQNYKILLRMIIKDNFLEMVQGSTVEEQDNTPRDDAGTNSARVLDRHIYKLNSEIDAFNQLINYPSTLFTLKTATGEALTVSLELPNYCNAKIEVSYTSFHAKFSEFKEAEEFLHFLVNEYVNKSQPPLNQGGEDPPLSVTSR |
Length | 608 |
Position | Head |
Organism | Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Kazachstania.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.428 |
Instability index | 45.62 |
Isoelectric point | 5.34 |
Molecular weight | 68662.19 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | activating transcription factor binding GO:0033613 IEA:EnsemblFungi
RNA polymerase II complex recruiting activity GO:0001139 IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP29907
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 95.83| 25| 36| 333| 357| 1
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300- 325 (18.62/ 9.08) ...FQEKLLRVRIfTKIaseEDYIFSGES
333- 357 (41.94/29.35) GSVFNNENIRGQI.SKL...KDIIFEKEL
372- 394 (35.27/23.55) GVSIENEN..KVV.MEL...PNEKFEIEL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.25| 14| 31| 415| 428| 2
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415- 428 (23.58/11.87) RRANLFLITLRMLL
448- 461 (24.67/12.70) RRGPEDILLLRPLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.79| 11| 23| 87| 97| 4
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87- 97 (20.27/13.00) INSMSGDEQPF
112- 122 (19.52/12.25) LNNRRGQDETF
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|