<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29892

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAVDSYVEVLDQMVKLFKVYKPGEVTLENILRLCQTLNLESFIEDVGEGTERLSTASKIIVIDIDFDKMEGKVKQVKLVLASTYNSFNYYAPDATGNPNKEDNILLNSLVNFADLKQFQANLQFLYLLDTYSQLDMENGSSTTNGHGNNNNADSSANSTNPIGGGNSLSSTTKNGKLDLFKYYTELVEFLGQYFIDFNIQLEVTPNLNSIFGIYIHSGDQILAVIKLAKAKSPTTRLYEYVYSKETKRWINEFPENYVNGLSLVMEIQDKAVWFPREFLSEDIIFERLKDDDFVAPIVDVLINNTTEGVNGSISNRLFNTSQNISLLNDFTTKLINVTKFDISNDNLDLVAEIQKWILWYNTVLQRIVETLNRNSLRGGSLDVPNGAENNEDDLGNKHGGRLRRQSIVVGSTTVHKRRKSSNKNKRPSFTESTMLKEQGLQQFNLHDILTQPVIEENGMDASNEEALVIEGDDDDKMDICADDEQVPTAGTAMHQLVISEDHISLNGKINCSLYEPPENWKKFFRAFETWAS
Length532
PositionMiddle
OrganismKazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.09
Grand average of hydropathy-0.395
Instability index37.11
Isoelectric point4.74
Molecular weight60102.68
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29892
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     261.62|      73|      84|     246|     321|       1
---------------------------------------------------------------------------
   19-   57 (41.69/24.89)	.............................VYKPGEVTLENIlrLCQTLNLESF........IEDVGEG.....TE....RLSTAS
  246-  321 (118.17/100.21)	TKRWIN..EFpeNYVN.GLSLVMEIQDKAVWFPREFLSEDI..IFERLKDDDFVAPIVDVlINNTTEGVNGSISN....RLFNTS
  331-  406 (101.76/74.59)	TTKLINvtKF..DISNdNLDLVAEIQKWILWY.NTVLQR....IVETLNRNSLRGGSLDV..PNGAENNEDDLGNkhggRLRRQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.77|      92|     322|      97|     197|       2
---------------------------------------------------------------------------
   97-  197 (144.08/111.82)	NPNKEDNILLNSLVNFADLKQFqaNLQflyllDTYSQ.LDMENGSSTTNG.....HGNNNN.ADSSANSTN.PIGGGN......SLSSTTKNGKLDLFKYytELVEFLGQYFIDF
  422-  527 (139.68/86.74)	NKNKRPSFTESTMLKEQGLQQF..NLH.....DILTQpVIEENGMDASNEealviEGDDDDkMDICADDEQvPTAGTAmhqlviSEDHISLNGKINCSLY..EPPENWKKFFRAF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29892 with Med1 domain of Kingdom Fungi
Unable to open file!