<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29892
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MAVDSYVEVLDQMVKLFKVYKPGEVTLENILRLCQTLNLESFIEDVGEGTERLSTASKIIVIDIDFDKMEGKVKQVKLVLASTYNSFNYYAPDATGNPNKEDNILLNSLVNFADLKQFQANLQFLYLLDTYSQLDMENGSSTTNGHGNNNNADSSANSTNPIGGGNSLSSTTKNGKLDLFKYYTELVEFLGQYFIDFNIQLEVTPNLNSIFGIYIHSGDQILAVIKLAKAKSPTTRLYEYVYSKETKRWINEFPENYVNGLSLVMEIQDKAVWFPREFLSEDIIFERLKDDDFVAPIVDVLINNTTEGVNGSISNRLFNTSQNISLLNDFTTKLINVTKFDISNDNLDLVAEIQKWILWYNTVLQRIVETLNRNSLRGGSLDVPNGAENNEDDLGNKHGGRLRRQSIVVGSTTVHKRRKSSNKNKRPSFTESTMLKEQGLQQFNLHDILTQPVIEENGMDASNEEALVIEGDDDDKMDICADDEQVPTAGTAMHQLVISEDHISLNGKINCSLYEPPENWKKFFRAFETWAS |
Length | 532 |
Position | Middle |
Organism | Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Kazachstania.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.395 |
Instability index | 37.11 |
Isoelectric point | 4.74 |
Molecular weight | 60102.68 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP29892
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 261.62| 73| 84| 246| 321| 1
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19- 57 (41.69/24.89) .............................VYKPGEVTLENIlrLCQTLNLESF........IEDVGEG.....TE....RLSTAS
246- 321 (118.17/100.21) TKRWIN..EFpeNYVN.GLSLVMEIQDKAVWFPREFLSEDI..IFERLKDDDFVAPIVDVlINNTTEGVNGSISN....RLFNTS
331- 406 (101.76/74.59) TTKLINvtKF..DISNdNLDLVAEIQKWILWY.NTVLQR....IVETLNRNSLRGGSLDV..PNGAENNEDDLGNkhggRLRRQS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 283.77| 92| 322| 97| 197| 2
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97- 197 (144.08/111.82) NPNKEDNILLNSLVNFADLKQFqaNLQflyllDTYSQ.LDMENGSSTTNG.....HGNNNN.ADSSANSTN.PIGGGN......SLSSTTKNGKLDLFKYytELVEFLGQYFIDF
422- 527 (139.68/86.74) NKNKRPSFTESTMLKEQGLQQF..NLH.....DILTQpVIEENGMDASNEealviEGDDDDkMDICADDEQvPTAGTAmhqlviSEDHISLNGKINCSLY..EPPENWKKFFRAF
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