<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29890

Description Uncharacterized protein
SequenceMNVAPGIETLTNDERARNVTELLQVLMDINDINGGNNETAEKMKVHVKNFESALYAKCSSKKEYLDSMRERVTAMKNTRDIRKKSSMNTAAAAATAKQQDIVLQQQQQQQQQQQQQQQQQQRQFQNNFNNEMQADGIGKPGNNGNFVPNTVNMNSRMFLNQQAQARQQAAQQLKTRQQQQQQDQRHQLTPEQQILINQMKVAPIPRELLQRIPKVPAGVNTWQQITELAQQKRFSPQDMQIAKEVYKIHQQLLYKSKMQQQARARAQVQAQAQVQAQAQAQVQNQNQGPLQSQPQMQSQPQAMNQKQGQQQRPMNRDGQQTVNVLNQISQIFTPEEQRTLLHEAMEACKQFQKTRYGANMADPDRQSFIRKYINQKALKKLQSMRMSQAAAVAANNGPIRQSIPDSRNASATNVVPPSASNFNNLSASGTSTAMGSQVPQLVPASQINSANVPNDKTNANAILLAQQQQQQTPQPQKPADAVRQQKANSKPLLHYLQPTQRDLETVRKISAEATKISLRLTDLTNAISAQEKEEIKRKLQLNQQLFAQVSNYAPQVYVFTKSEVFLKEVLQLRIFVKEILEKCAKGIYVVKLDTVDKLVMKYQKYWESMKLQLLRRQQLIQQQQTQPGGTPQQIERSNNGTAGAPDNAMMQQKRLQQIQQQMQNKQQWQLQQQQQQQQNMAAMNMNAFSPPASTNAPKSQNNMPQFNAGQLSGNAPDMKKRKTSATPQLPHAAHATATPDFHTISPMAVGQTGTSPVKDATGLHQRSKSSSKKLSPMNLNNGVSLNANALASGNKAATPTSLNNVGPSPSLVGRTGTIPQHSPTPSQSNAATGVSAVAPSPFKKEEDMLESLNVRKAEVVSRFKHRQELFQNSPIDTFLSTLADTFGIKDESMDPPVVKFSQQVIDQVNGTGRKKITKAAQRVRDKDVVDVEINDSNKLIMRSKVAKEGRSYGIKLSSISDVFGQATGIHDYDMCVGLMTDFDKTGSGIGRKRKMDDSMLGDEVSPSTGSLMGDSKRVKIDSPDDMFVDDHIKMNGPRNMNTGGTTNADKSANIWNWGFWTPEMGAVENA
Length1070
PositionTail
OrganismKazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.04
Grand average of hydropathy-0.815
Instability index48.87
Isoelectric point9.80
Molecular weight119317.34
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29890
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     427.10|      68|      69|      85|     152|       1
---------------------------------------------------------------------------
   85-  147 (105.09/30.41)	........................................SS.MN........TAAAAATAKQQDIVLQQQQQQQQQQQ...QQQ.QQQQRQF....QNN......FNNEMQA....D..GIGKPGN...NGNFV
  148-  215 (80.25/21.69)	PNTVN.................................mnSR.MF........LN.QQAQARQQ..AAQQLKTRQQQQQ...QDQ.RHQLTPE....QQI......LINQMKV....A..PI..PREllqRIPKV
  278-  341 (64.07/16.00)	.......................................................AQAQVQNQNQGPLQSQPQMQSQPQamnQKQ.GQQQRPMnrdgQQT......VNVLNQI....S..QIFTPEE...QRTLL
  342-  438 (52.27/11.86)	HEAMEackqfqktryganmadpdrqsfirkyinqkalkklQS.MR........MSQAAAVAANNGPI...RQSIPDSRN...ASA.TNVVPPS....ASN......FNN.LSA....S..G..TSTA...MGSQV
  439-  509 (51.13/11.46)	PQLVP...................................ASqINsanvpndkTNANA.......ILLAQQQQQQTPQP...QKP.ADAVRQQ....KANskpllhYLQPTQR....DleTVRK..........I
  639-  703 (74.28/19.59)	....N...................................G...T.........AGAPDNAMMQQKRLQQIQQQMQNKQ...QWQlQQQQQQQ....QNM......AAMNMNAfsppA..STNAPKS...QNN.M
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.14|      33|      76|     879|     915|       2
---------------------------------------------------------------------------
  879-  915 (48.41/52.16)	LSTLADTF....GIKDESMdppVVKFSQQvIDQV.NGTGRKK
  956-  993 (51.73/38.51)	LSSISDVFgqatGIHDYDM...CVGLMTD.FDKTgSGIGRKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.96|      29|      29|     734|     762|       3
---------------------------------------------------------------------------
  734-  762 (53.47/36.99)	HATATP.DFHTI..SPMAVGQTGT....SPVKD....ATG
  764-  793 (39.27/24.96)	HQRSKS.SSKKL..SPMNLNN.GV....SLNAN..alASG
  794-  833 (30.22/17.29)	NKAATPtSLNNVgpSPSLVGRTGTipqhSPTPSqsnaATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.79|      16|      71|     533|     548|       4
---------------------------------------------------------------------------
  256-  271 (20.74/ 8.38)	SKMQQQARARAQVQAQ
  533-  548 (24.63/11.35)	EEIKRKLQLNQQLFAQ
  607-  622 (23.42/10.42)	ESMKLQLLRRQQLIQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.59|      11|      20|     840|     850|       7
---------------------------------------------------------------------------
  840-  850 (19.03/11.93)	SPFKKEEDMLE
  861-  871 (19.56/12.46)	SRFKHRQELFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.56|      10|      24|     994|    1003|       9
---------------------------------------------------------------------------
  994- 1003 (19.15/13.25)	KMD..DSMLGDE
 1019- 1030 (14.41/ 8.08)	KIDspDDMFVDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29890 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQVQAQAQAQVQNQNQGPLQSQPQMQSQPQAMNQKQGQQQRPMNRDGQQTVNVLNQI
2) DSMRERVTAMKNTRDIRKKSSMNTAAAAATAKQQDIVLQQQQQQQQQQQQQQQQQQRQFQNNFNNEMQADGIGKPGNNGNFVPNTVNMNSRMFLNQQAQARQQAAQQLKTRQQQQQQDQRHQLTPEQQILIN
3) IQQQQTQPGGTPQQIERSNNGTAGAPDNAMMQQKRLQQIQQQMQNKQQWQLQQQQQQQQNMAAMNMNAFSPPASTNAPKSQNNMPQFNAGQLSGNAPDMKKRKTSATPQLPHAAHATATPDFHTISPMAVGQTGTSPVKDATGLHQRSKSSSKKLSPMNLNNGVSLNANALASGNKAATPTSLNNVGPSPSLVGRTGTIPQHSPTPSQSNAATGVSAVAPSPFKKEEDMLES
4) SMRMSQAAAVAANNGPIRQSIPDSRNASATNVVPPSASNFNNLSASGTSTAMGSQVPQLVPASQINSANVPNDKTNANAILLAQQQQQQTPQPQKPADAVRQQKANSKPLLHYLQ
272
66
620
383
328
197
851
497










Molecular Recognition Features






MoRF SequenceStartStop




1) FIRKYI
368
373